DoD Peer Reviewed Medical Clinical Trial Award | Apply Online

Opportunity Summary:

The DoD Peer Reviewed Medical Clinical Trial Award (PRMRP CTA), Funding Opportunity Number W81XWH-15-PRMRP-CTA, is a U.S. Department of Defense research funding opportunity administered through the Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA). It is part of the Congressionally Directed Medical Research Programs (CDMRP) Peer Reviewed Medical Research Program (PRMRP) and is intended to accelerate the launch and execution of clinical trials that could meaningfully change prevention, diagnosis, treatment, or clinical management for diseases and conditions that fall under at least one of the FY15 PRMRP Congressionally directed Topic Areas. The central theme is speed and impact: proposals are expected to move quickly into clinical testing and to be positioned to produce results that could influence clinical practice, medical decision-making, or further product development.

This award mechanism supports a broad range of clinical trial types and stages. Applicants can propose early, smaller studies that establish feasibility or generate the data needed to design more definitive trials, including proof-of-concept efforts, pilot studies, first-in-human investigations, and Phase 0 trials. At the other end of the spectrum, it also supports larger, later-stage trials designed to determine efficacy in relevant patient populations. The scope includes trials evaluating new or improved medical products and interventions, including pharmacologic agents (drugs and biologics), medical devices, clinical guidance or care pathways, and emerging approaches and technologies. In other words, the program is not limited to one intervention category; it is structured to fund clinical testing across multiple translational routes as long as the work aligns with the specified PRMRP Topic Areas and is positioned to deliver clinically meaningful outcomes.

A key requirement is relevance to military health needs. Every proposed study must be responsive to the healthcare needs of military Service members, Veterans, and/or beneficiaries. However, the opportunity explicitly states that enrolling military or Veteran participants is not required, which allows investigators to conduct trials in civilian or mixed populations as long as the underlying disease burden, outcomes, or care challenges being addressed are clearly tied to military-relevant health priorities. This emphasis typically means applicants need to articulate a strong rationale for how the trial results would translate to improved health, readiness, recovery, long-term care, or quality of life in DoD-connected populations, even if the trial is run outside military treatment facilities.

From a funding and administrative standpoint, the award is offered as either a cooperative agreement or a grant, under the federal assistance listing (CFDA) number 12.420 (Military Medical Research and Development). The opportunity anticipated making about 8 awards, with an estimated total funding level of $48,000,000, and it did not require cost sharing or matching. Eligibility was listed as unrestricted, meaning it was broadly open to various types of organizations (subject to any additional eligibility clarifications contained in the full announcement). The posting date and creation date were April 17, 2015, with an original and final closing date of October 22, 2015, and an archive date of November 21, 2015, indicating this specific solicitation is historical but still useful as a reference for understanding the PRMRP CTA’s intent and structure.

For applicant support and technical access issues, the announcement directed users to the CDMRP help desk via eBRAP (help@eBRAP.org, 301-682-5507), which is the platform commonly used for CDMRP submission and pre-award coordination.

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