DoD Peer Reviewed Medical Discovery Award | Apply Online

Opportunity Summary:

The DoD Peer Reviewed Medical Research Program (PRMRP) Discovery Award (Funding Opportunity Number W81XWH-11-PRMRP-DA) is a U.S. Department of Defense medical research funding opportunity administered through the Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA). It is designed specifically to push early-stage, unconventional ideas forward in areas relevant to military medical research and development, with an emphasis on work that is genuinely exploratory rather than incremental. The program is aimed at enabling investigators to test bold new concepts, introduce new paradigms or methods, and explore theories that may be considered too preliminary or too risky for more conservative funding mechanisms, while still being scientifically grounded.

The central purpose of this Discovery Award is to support innovative and untested research that carries high risk but also the possibility of high reward. In practical terms, that means the DoD is looking for proposals that could open up entirely new directions for medical science or significantly change how a problem is approached, even if the approach is not yet proven. At the same time, the solicitation makes clear that the research cannot be speculative in a loose sense: projects are expected to be built around a well-formulated, testable hypothesis, supported by a strong scientific rationale and a sound study design. The outcome expected from funded work is the development of robust preliminary data, meaning results solid enough to justify and power follow-on studies and to serve as a foundation for future grant applications and broader research programs.

This opportunity was offered under either a cooperative agreement or a grant mechanism (as listed under FundingInstrumentType), indicating that awards could take different federal assistance forms depending on how the project is structured and the level of anticipated involvement from the sponsoring agency. The opportunity falls under the Science and Technology and other Research and Development activity category and is associated with CFDA number 12.420, Military Medical Research and Development. Cost sharing or matching was not required, which reduces barriers for applicants who may not have discretionary institutional funds to contribute.

Funding for the solicitation was estimated at a total of $3,750,000, with an expectation of approximately 20 awards. This implies relatively modest average funding per award, consistent with the program's focus on early, discovery-stage efforts intended to generate preliminary data rather than to fully mature and validate a technology or clinical approach. The eligibility category is listed as unrestricted, meaning the competition was open to any type of entity, subject to any specific clarifications contained in the full announcement, which often includes standard federal eligibility and compliance requirements.

Key dates for the opportunity show it was posted on April 22, 2011, with a closing date of July 5, 2011, and an archive date of August 4, 2011. For applicants needing assistance obtaining or accessing the full announcement, the contact provided was the CDMRP Help Desk at 301-682-5507. Overall, the PRMRP Discovery Award can be understood as a DoD mechanism for seeding high-impact medical research ideas at the earliest stages, requiring rigorous hypothesis-driven planning while intentionally encouraging novel, high-upside concepts that can produce strong preliminary findings for future expansion.

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