Opportunity Information: Apply for W81XWH 12 PRMRP IIRA

  • The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Peer Reviewed Medical Investigator Initiated Research Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
  • This funding opportunity was created on Feb 28, 2012 and posted on Feb 28, 2012.
  • Applicants must submit their applications by Jul 31, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $25,900,000.00 to eligible and selected applicants.
  • The number of recipients for this funding is limited to 23 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:

The DoD Peer Reviewed Medical Research Program (PRMRP) Investigator Initiated Research Award (IIRA) is a Department of Defense funding opportunity designed to support investigator-driven medical research projects that can make a meaningful impact on research and/or patient care. The emphasis is on studies that address a disease or condition aligned with at least one of the Congressionally directed FY12 PRMRP topic areas. In practice, this means applicants must clearly connect their proposed work to one or more of those specified topic areas and demonstrate why the project matters for advancing knowledge, improving clinical practice, or both.

This award is intentionally broad in the kinds of science it will support, allowing projects across the full research spectrum. Proposals may range from basic laboratory research to translational research, including preclinical studies using animal models, studies involving human subjects, and correlative studies that are tied to an existing clinical trial. The program also recognizes that strong research ideas can originate from different starting points, such as a new laboratory finding, patterns observed in population-based datasets, or insights derived from direct clinical experience with patients (including well-supported anecdotal observations). Regardless of the origin of the idea, the application is expected to present a clear scientific rationale and show how the work could contribute in an important way to the field or to patient outcomes.

A key requirement is that applications include relevant supporting data that justify the proposed study and demonstrate feasibility. The announcement explicitly allows these supporting data to be unpublished and/or drawn from published literature, as long as they credibly support the rationale. This expectation signals that proposals should not be purely speculative; they should be grounded in evidence that the approach is plausible and that the project can realistically be executed.

Administratively, this opportunity was posted February 28, 2012, with an original and final closing date of July 31, 2012, and an archive date of August 30, 2012. The funding instrument types include cooperative agreements and grants, and it falls under the Science and Technology and other Research and Development activity category. The program anticipated making about 23 awards, with an estimated total funding level of $25.9 million. The CFDA listing associated with this opportunity is 12.420 (Military Medical Research and Development). Cost sharing or matching is not required, which reduces the financial burden on applicants and can broaden participation.

Eligibility is listed as unrestricted, meaning it is open to any type of entity, subject to any additional clarifications that may have appeared in the full announcement under eligibility details. The administering agency is the Department of the Army, specifically USAMRAA. For assistance obtaining or accessing the full announcement, the notice provides the CDMRP Help Desk contact information (301-682-5507 and help@cdmrp.org).

Frequently Asked Questions (FAQs)

What is the PRMRP Investigator Initiated Research Award (IIRA)?

The Peer Reviewed Medical Research Program (PRMRP) Investigator Initiated Research Award (IIRA) is a Department of Defense (DoD) funding opportunity that supports investigator-driven medical research projects intended to make a meaningful impact on research and/or patient care.

What is the main goal of this award?

The award aims to fund medical research that can significantly advance knowledge, improve clinical practice, or contribute to better patient outcomes, as long as the project is aligned with at least one of the Congressionally directed FY12 PRMRP topic areas.

Do projects have to align with specific topic areas?

Yes. Applicants must clearly connect their proposed research to one or more of the Congressionally directed FY12 PRMRP topic areas and explain why that alignment matters for research impact and/or patient care.

What kinds of research projects are supported?

This opportunity is intentionally broad and can support projects across the full research spectrum, including basic laboratory research and translational research.

Are preclinical animal studies allowed?

Yes. The program explicitly includes translational research and preclinical studies using animal models as examples of work that may be supported.

Are studies involving human subjects allowed?

Yes. Studies involving human subjects are included among the types of research projects the program may support.

Can an application be based on data from an existing clinical trial?

Yes. The program allows correlative studies that are tied to an existing clinical trial.

Where can strong project ideas come from?

The program recognizes that strong research ideas can originate from multiple starting points, including new laboratory findings, patterns observed in population-based datasets, or insights derived from direct clinical experience with patients (including well-supported anecdotal observations).

What does the program expect in terms of scientific rationale?

Regardless of how the idea originated, the application is expected to provide a clear scientific rationale and explain how the work could contribute in an important way to the field and/or to patient outcomes.

Is supporting data required with the application?

Yes. A key requirement is that applications include relevant supporting data that justify the proposed study and demonstrate feasibility.

Can the supporting data be unpublished?

Yes. Supporting data may be unpublished and/or drawn from published literature, as long as the evidence credibly supports the study rationale and feasibility.

Does the program fund speculative ideas without evidence?

The announcement indicates proposals should not be purely speculative. Applications are expected to be grounded in evidence showing the approach is plausible and that the project can realistically be executed.

What funding instruments are used for this opportunity?

The funding instrument types listed for this opportunity include cooperative agreements and grants.

Which agency administers this opportunity?

The administering agency is the Department of the Army, specifically USAMRAA.

When was this opportunity posted, and what were the closing dates?

The opportunity was posted on February 28, 2012. The original closing date and final closing date were both July 31, 2012. The archive date was August 30, 2012.

How many awards were anticipated and what was the estimated total funding level?

The program anticipated making about 23 awards, with an estimated total funding level of $25.9 million.

Is cost sharing or matching required?

No. Cost sharing or matching is not required for this opportunity.

Who is eligible to apply?

Eligibility is listed as unrestricted, meaning it is open to any type of entity, subject to any additional clarifications that may have been included under eligibility details in the full announcement.

What is the CFDA number associated with this program?

The CFDA listing associated with this opportunity is 12.420 (Military Medical Research and Development).

What activity category does this opportunity fall under?

The activity category is listed as Science and Technology and other Research and Development.

Who can I contact for help accessing the full announcement?

For assistance obtaining or accessing the full announcement, the notice provides the CDMRP Help Desk contact information: 301-682-5507 and help@cdmrp.org.

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