DoD Peer Reviewed Medical Investigator Initiated Research Award | Apply Online

Opportunity Summary:

The DoD Peer Reviewed Medical Research Program (PRMRP) Investigator Initiated Research Award (IIRA) is a Department of Defense funding opportunity designed to support high-impact, investigator-driven medical research projects. The intent is to fund studies that can make an important contribution to understanding how a disease or condition begins (initiation), how it worsens over time (progression), and/or how patient care can be improved. Projects must align with at least one of the congressionally directed FY11 PRMRP topic areas, meaning the research focus needs to fit within the specific set of medical topics Congress identified for that fiscal year.

This award supports a broad range of research stages, from foundational basic science through translational efforts that move discoveries toward clinical application. Applicants can propose laboratory-based studies that explore biological mechanisms, as well as preclinical research in animal models aimed at testing hypotheses or potential interventions before moving into humans. The opportunity also allows for research involving human subjects where appropriate, and it explicitly includes correlative studies that are connected to an existing clinical trial, such as analyses of biomarkers, immune responses, genetics, or other clinical or biological measures that help interpret trial outcomes and deepen understanding of disease behavior.

A key feature of the program is that it encourages ideas grounded in real observations, regardless of where those observations originate. Research concepts may come from a laboratory discovery, findings from population-based studies, or a clinician's direct experience with patients, including insights drawn from first-hand patient care and anecdotal patterns that suggest a testable scientific question. In other words, the program is meant to capture promising, well-justified ideas that could meaningfully advance medical knowledge or care, even if the starting point is a practical clinical observation rather than a purely theoretical framework.

Administratively, this was a discretionary federal funding opportunity offered by the Department of the Army through the U.S. Army Medical Research Acquisition Activity (USAMRAA) under Funding Opportunity Number W81XWH-11-PRMRP-IIRA. Awards were made as grants and/or cooperative agreements, with an expected total of 23 awards and an estimated total funding level of $25,875,000. There was no cost sharing or matching requirement, and eligibility was listed as unrestricted (open to any type of entity), subject to any additional eligibility clarifications provided in the full announcement. The opportunity was posted on April 22, 2011, with an application deadline of July 5, 2011, and it was archived on August 4, 2011. The CFDA number associated with the program was 12.420 (Military Medical Research and Development). For applicants who had trouble accessing the full announcement electronically, the listed support contact was the CDMRP Help Desk at 301-682-5507.

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