DoD Prostate Cancer Clinical Exploration Award | Apply Online

Opportunity Summary:

The DoD Prostate Cancer Clinical Exploration Award (Funding Opportunity Number W81XWH-12-PCRP-CEA) is a Department of Defense funding opportunity administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA) under CFDA 12.420 (Military Medical Research and Development). It is designed to move quickly on promising, hypothesis-driven ideas by supporting early phase clinical trials and clinical studies that are directly tied to patient care, including correlative studies connected to ongoing or existing clinical trials. The central aim is to test innovative and largely unproven concepts that could meaningfully change how prostate cancer is managed in the clinic, generating the scientific rationale and early proof-of-principle data needed to justify larger, definitive trials.

The program emphasizes speed and practical clinical relevance. Projects are expected to be ready to launch soon after award, with clinical trials anticipated to begin within 12 months of the award date. In keeping with that fast-start expectation, any required regulatory clearances must already be secured prior to submitting an application. Specifically, if the proposed intervention requires an Investigational New Drug (IND) application or an Investigational Device Exemption (IDE), those approvals must be in place before the proposal is submitted, not after selection. This requirement signals that the award is meant for teams that have already completed key preparatory work and are positioned to execute without long regulatory delays.

A wide range of intervention types is considered responsive, reflecting an interest in both medical and non-medical approaches that could improve outcomes for patients with prostate cancer. Interventions may include pharmaceuticals, devices, biologics, surgical techniques or procedures, and behavior modification strategies, as well as other clinically relevant approaches. In addition to trials that directly test an intervention, the opportunity also supports studies that are correlative to existing trials, such as research that leverages patient samples, biomarkers, imaging, or other clinical data streams to clarify mechanisms, identify predictors of response, or refine patient selection strategies. The common thread across these options is an expectation that the work will provide actionable clinical insight and a credible early signal of benefit or feasibility that can guide next-stage development.

In terms of award mechanics, the opportunity uses grant and cooperative agreement funding instruments and falls under the broad category of science, technology, and other research and development. The total estimated funding for this cycle is $2.2 million, with an expected three awards. There is no cost sharing or matching requirement, which reduces the need for applicants to bring non-federal funds to the table. Eligibility is listed as unrestricted, meaning it is broadly open to organizations and entity types, subject to any additional eligibility details that may have been provided in the full announcement.

Key dates for this archived 2012 competition include a posted date of March 20, 2012, and an application deadline of August 23, 2012, with the archive date listed as September 22, 2012. For assistance accessing the full announcement (as referenced in the original posting), the contact listed is the CDMRP Help Desk at 301-682-5507. Overall, this award is geared toward teams ready to rapidly execute a well-justified, early clinical test of a novel prostate cancer intervention or a tightly linked correlative clinical study, with the explicit goal of producing the kind of early clinical evidence that can propel larger trials and, ultimately, influence patient management.

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