Opportunity Information: Apply for W81XWH 14 PCRP EHDA
Apply for W81XWH 14 PCRP EHDA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Prostate Cancer Exploration Hypothesis Development Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on May 30, 2014 and posted on May 30, 2014.
- Applicants must submit their applications by Jul 9, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,400,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 20 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Prostate Cancer Research Program (PCRP) Exploration Hypothesis Development Award (EHDA) is a grant opportunity run by the Department of the Army through USAMRAA that is meant to jump-start bold, early-stage prostate cancer ideas that are still untested. It is specifically geared toward high-risk, high-reward research: new concepts, theories, approaches, or methods that could open up entirely new directions in prostate cancer research. The goal is not to fund incremental work, but to give investigators room to explore a promising idea that may be based on strong logic, an unexpected observation, or a new way of looking at a problem, and to generate enough rationale or proof-of-principle evidence to support a future, more developed hypothesis.
A defining feature of this mechanism is that preliminary data is strongly discouraged, because the program is trying to avoid turning this into a typical grant where applicants need a large package of existing results. Instead, proposals are expected to be built on clear reasoning, a sound scientific rationale, and a compelling argument for why the concept is innovative and why it could matter for an important prostate cancer problem. Since the mechanism began in FY03, the program reports receiving 2,184 applications and recommending 237 for funding, which signals that it is competitive and selective while still functioning as a pipeline for unconventional ideas.
The opportunity is open to investigators across a broad range of disciplines, reflecting the program's interest in solutions that may come from outside traditional prostate cancer biology. The announcement explicitly welcomes areas such as basic science, engineering, bioinformatics, population science, translational research, and clinical research. At the program level, applicants are expected to align their proposed work with at least one PCRP focus area and at least one of the PCRP overarching challenges, meaning the idea should connect to the program's defined priorities rather than being prostate-cancer-related in only a generic sense.
Human subjects research is encouraged, but there is a firm boundary: clinical trials are not allowed under this award. The program will allow correlative studies that are tied to an existing clinical trial, but only when the work is considered no greater than minimal risk and is approved through the relevant oversight pathway, including review by the local Institutional Review Board (IRB) and the USAMRMC Office of Research Protections, Human Research Protection Office (HRPO). For studies involving human subjects or human specimens, the work must qualify as exempt under 32 CFR 219.101(b) or be eligible for expedited review under 32 CFR 219.110 or 21 CFR 56.110. In practical terms, this steers applicants toward lower-risk observational or specimen-based projects, secondary analyses, or minimal-risk correlative research rather than interventions that would trigger a clinical trial framework.
For applicants who plan to use retrospectively collected human specimens or linked clinical and demographic data, the program encourages leveraging existing PCRP-supported resources such as the Prostate Cancer Biorepository Network (PCBN) and the North Carolina-Louisiana Prostate Cancer Project (PCaP). The intent is to help teams move quickly and efficiently, especially when early testing of a novel hypothesis can be accelerated by access to established biospecimen collections and well-annotated datasets.
From the funding and administrative side, this FY14 opportunity (Funding Opportunity Number W81XWH-14-PCRP-EHDA) was offered as a discretionary grant/cooperative agreement under CFDA 12.420 (Military Medical Research and Development). The expected number of awards was 20, with an estimated total funding amount of $2.4 million and no cost sharing or matching requirement. Eligibility is listed as unrestricted, meaning a wide range of organizations could apply unless further limited by additional eligibility text in the full announcement. The opportunity was posted May 30, 2014, and closed July 9, 2014 (and archived August 8, 2014). For assistance accessing the full announcement, the contact listed is the CDMRP Help Desk at 301-682-5507.
FAQs: DoD Prostate Cancer Research Program (PCRP) Exploration Hypothesis Development Award (EHDA)
What is the PCRP Exploration Hypothesis Development Award (EHDA)?
The EHDA is a Department of Defense Prostate Cancer Research Program funding mechanism run by the Department of the Army through USAMRAA. It is designed to jump-start bold, early-stage prostate cancer research ideas that are still untested.
What kind of research is this award meant to support?
This award targets high-risk, high-reward projects, including new concepts, theories, approaches, or methods that could open entirely new directions in prostate cancer research. The intent is to support exploration and early proof-of-principle, not incremental extensions of established work.
Is this award intended to fund incremental or highly developed projects?
No. The program position is that the goal is not to fund incremental work. Projects should focus on exploring a promising but untested idea and generating enough rationale or proof-of-principle evidence to support a future, more developed hypothesis.
Are preliminary data required for an EHDA application?
No. Preliminary data are strongly discouraged under this mechanism. Applications are expected to be based on clear reasoning, a sound scientific rationale, and a compelling argument for innovation and potential impact on an important prostate cancer problem.
If preliminary data are discouraged, what should the application be built on?
Proposals are expected to be grounded in strong logic and scientific rationale, potentially motivated by an unexpected observation or a new way of looking at a problem. The application should clearly explain why the concept is innovative and why it matters for prostate cancer.
How competitive is the EHDA?
The program reports that since FY03 it received 2,184 applications and recommended 237 for funding, indicating a competitive and selective process while still serving as a pipeline for unconventional ideas.
Who can apply for this opportunity?
Eligibility is listed as unrestricted, meaning a wide range of organizations could apply unless additional eligibility limitations were included elsewhere in the full announcement.
What disciplines are encouraged to apply?
The opportunity is open to investigators across a broad range of disciplines. The announcement explicitly welcomes basic science, engineering, bioinformatics, population science, translational research, and clinical research, reflecting interest in solutions that may come from outside traditional prostate cancer biology.
Does the proposed research have to align with PCRP priorities?
Yes. Applicants are expected to align the proposed work with at least one PCRP focus area and at least one of the PCRP overarching challenges, so the project connects to the program's defined priorities rather than being only broadly prostate-cancer-related.
Is human subjects research allowed under the EHDA?
Yes. Human subjects research is encouraged, but it must fall within the program's boundaries (including the prohibition on clinical trials and the requirement for minimal-risk pathways where applicable).
Are clinical trials allowed under this award?
No. Clinical trials are not allowed under the EHDA.
Are correlative studies related to clinical trials allowed?
Yes, correlative studies tied to an existing clinical trial may be allowed, but only when the work is considered no greater than minimal risk and receives the required oversight approvals.
What oversight approvals are referenced for human subjects work?
Human subjects work must be approved through relevant oversight pathways, including review by the local Institutional Review Board (IRB) and the USAMRMC Office of Research Protections, Human Research Protection Office (HRPO), as referenced in the opportunity description.
What level of risk is expected for human subjects or specimen-based studies?
In practical terms, the opportunity steers applicants toward lower-risk projects such as observational or specimen-based work, secondary analyses, or minimal-risk correlative research, rather than interventions that would trigger a clinical trial framework.
What regulatory categories are mentioned for human subjects research eligibility?
For studies involving human subjects or human specimens, the work must qualify as exempt under 32 CFR 219.101(b) or be eligible for expedited review under 32 CFR 219.110 or 21 CFR 56.110.
Can retrospectively collected human specimens or linked clinical and demographic data be used?
Yes. The program encourages the use of retrospectively collected human specimens and/or linked clinical and demographic data, particularly to accelerate early testing of a novel hypothesis.
Are there specific PCRP-supported resources the program encourages applicants to use?
Yes. For retrospectively collected human specimens or linked datasets, the opportunity encourages leveraging PCRP-supported resources such as the Prostate Cancer Biorepository Network (PCBN) and the North Carolina-Louisiana Prostate Cancer Project (PCaP).
What is the Funding Opportunity Number for this EHDA?
The Funding Opportunity Number listed is W81XWH-14-PCRP-EHDA.
What fiscal year is associated with this opportunity?
This is described as an FY14 opportunity.
What type of funding instrument is used?
The opportunity was offered as a discretionary grant/cooperative agreement.
What CFDA number is associated with this program?
The CFDA number listed is 12.420 (Military Medical Research and Development).
How many awards were expected and what was the estimated total funding?
The opportunity anticipated 20 awards with an estimated total funding amount of $2.4 million.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
When was the opportunity posted and when did it close?
It was posted on May 30, 2014, and closed on July 9, 2014. It was archived on August 8, 2014.
Who is the contact for assistance accessing the full announcement?
The contact listed is the CDMRP Help Desk at 301-682-5507.
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| DoD Prostate Cancer Laboratory Clinical Transition Award Apply for W81XWH 14 PCRP LCTA Funding Number: W81XWH 14 PCRP LCTA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Prostate Cancer Postdoctoral Training Award Apply for W81XWH 14 PCRP PTA Funding Number: W81XWH 14 PCRP PTA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Prostate Cancer Physician Research Training Award Apply for W81XWH 14 PCRP PRTA Funding Number: W81XWH 14 PCRP PRTA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Prostate Cancer Dr. Barbara Terry Koroma Health Disparity Research Award Apply for W81XWH 14 PCRP HDRA Funding Number: W81XWH 14 PCRP HDRA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Prostate Cancer Collaborative Undergraduate Historically Black Colleges and Universities Student Summer Training Program Award Apply for W81XWH 14 PCRP STPA Funding Number: W81XWH 14 PCRP STPA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Prostate Cancer Population Science Impact Award Apply for W81XWH 14 PCRP PSIA Funding Number: W81XWH 14 PCRP PSIA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
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| DoD Spinal Cord Injury Investigator Initiated Research Award Apply for W81XWH 14 SCIRP IIRA Funding Number: W81XWH 14 SCIRP IIRA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Spinal Cord Injury Qualitative Research Award Apply for W81XWH 14 SCIRP QRA Funding Number: W81XWH 14 SCIRP QRA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Spinal Cord Injury Translational Research Award Apply for W81XWH 14 SCIRP TRA Funding Number: W81XWH 14 SCIRP TRA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Spinal Cord Injury Clinical Trial Award Apply for W81XWH 14 SCIRP CTA Funding Number: W81XWH 14 SCIRP CTA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
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