Opportunity Information: Apply for W81XWH 10 PCRP EHDA
Apply for W81XWH 10 PCRP EHDA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Prostate Cancer Exploration Hypothesis Development Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Feb 2, 2010 and posted on Feb 2, 2010.
- Applicants must submit their applications by Mar 31, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,400,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 20 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Prostate Cancer Research Program (PCRP) Exploration Hypothesis Development Award (EHDA) is a Department of the Army, USAMRAA funding opportunity meant to push early-stage, high risk/high gain ideas in prostate cancer research. The program is set up specifically for exploring concepts that are genuinely new and untested, including novel theories, paradigms, or methods that could open up entirely different directions in the field. The emphasis is on creativity and innovation rather than incremental work, with the goal of generating a strong scientific rationale for a new hypothesis or providing an initial proof of principle that an unconventional idea might be viable.
A defining feature of this award is that preliminary data cannot be included or used as a requirement for competitiveness. Instead, applicants are expected to make a persuasive case through logical reasoning, a well-structured scientific argument, and clear justification for why the approach could matter for an important prostate cancer problem. The award is also framed as a mechanism for acting on serendipitous observations, meaning it is designed to let researchers follow up on unexpected findings that could lead to new avenues of investigation, even when those leads are not yet supported by a traditional body of preliminary evidence.
Because EHDA projects are intended to be preliminary and exploratory, there are strict limits on studies involving human subjects or human specimens. Research with human involvement is not supported unless it qualifies as exempt under 32 CFR 219.101(b) or is eligible for expedited review under 32 CFR 219.110 or 21 CFR 56.110. Applications that propose human subjects or specimen work that does not fall into those exempt or expedited categories will be administratively withdrawn, which makes the regulatory fit and human-subjects protection plan a key eligibility and compliance checkpoint for applicants considering any human-related components.
From the administrative and funding details provided, this opportunity was posted February 2, 2010 (Funding Opportunity Number W81XWH-10-PCRP-EHDA) and closed March 31, 2010, with an archive date of April 30, 2010. It is listed as a discretionary opportunity and uses grant and cooperative agreement funding instruments under the Science and Technology/Research and Development activity category. The program anticipated making about 20 awards, with an estimated total funding level of $2.4 million, and it did not require cost sharing or matching. Eligibility was broadly described as unrestricted, meaning it was open to many entity types unless further limited by additional eligibility language in the full announcement.
The track record information included in the announcement gives a sense of competitiveness and program history: since the award was introduced in FY03, 665 applications had been received and 115 were recommended for funding. For applicants, that history reinforces the award’s role as a selective, innovation-focused mechanism intended to seed brand-new ideas in prostate cancer research rather than support mature projects already backed by extensive datasets.
For assistance, the announcement points applicants to the CDMRP help resources, including contact options for accessing the full announcement and for electronic submission support (PA HELP at 301-619-7079 and cdmrp.pa@amedd.army.mil; eReceipt HELP at 301-682-5507 and help@cdmrp.org).
FAQs: DoD Prostate Cancer Research Program (PCRP) Exploration Hypothesis Development Award (EHDA)
What is the PCRP Exploration Hypothesis Development Award (EHDA)?
The EHDA is a Department of Defense Prostate Cancer Research Program (PCRP) funding opportunity administered through the Department of the Army/USAMRAA. It is intended to push early-stage, high risk/high gain ideas in prostate cancer research, especially concepts that are genuinely new and untested.
What kinds of projects is this award designed to support?
This award is designed for exploratory, preliminary projects that introduce novel theories, paradigms, or methods that could open entirely different directions in prostate cancer research. The emphasis is on creativity and innovation rather than incremental advances.
Is the EHDA meant for mature projects with extensive supporting evidence?
No. The EHDA is positioned as a seed mechanism for brand-new ideas, not as support for mature projects already backed by extensive datasets or well-established preliminary results.
Are preliminary data required to apply?
No. A defining feature of the EHDA is that preliminary data cannot be included or used as a requirement for competitiveness.
If preliminary data are not allowed, what makes an application competitive?
Applicants are expected to make a persuasive case through logical reasoning, a well-structured scientific argument, and a clear justification of why the approach could matter for an important prostate cancer problem. The goal is to build a strong scientific rationale for a new hypothesis or provide an initial proof of principle for an unconventional idea.
Does the opportunity encourage pursuing unexpected or serendipitous findings?
Yes. The EHDA is framed as a mechanism for acting on serendipitous observations, allowing researchers to follow up on unexpected findings that could lead to new avenues of investigation even without a traditional body of preliminary evidence.
Can EHDA-funded projects include human subjects research?
Human subjects research is not supported unless it qualifies as exempt under 32 CFR 219.101(b) or is eligible for expedited review under 32 CFR 219.110 or 21 CFR 56.110.
Can EHDA-funded projects include research with human specimens?
Work involving human specimens is subject to the same strict limits described for human involvement. It is not supported unless it falls into the exempt or expedited categories referenced (32 CFR 219.101(b), 32 CFR 219.110, or 21 CFR 56.110).
What happens if an application proposes human subjects or human specimen work that is not exempt or expedited?
Applications proposing human subjects or specimen work that does not fall into the exempt or expedited categories will be administratively withdrawn.
Why is the human-subjects regulatory category important for this award?
Because non-exempt/non-expedited human involvement is not supported and can trigger administrative withdrawal, the regulatory fit and the human-subjects protection approach are key compliance checkpoints for applications with any human-related components.
What is the main goal of the EHDA?
The main goal is to generate a strong scientific rationale for a new hypothesis or provide an initial proof of principle that an unconventional idea might be viable, with a strong emphasis on innovation and new directions in prostate cancer research.
Who is the funding agency for this opportunity?
The opportunity is associated with the Department of the Army and USAMRAA, under the DoD Prostate Cancer Research Program (PCRP).
What is the Funding Opportunity Number for this EHDA announcement?
The Funding Opportunity Number is W81XWH-10-PCRP-EHDA.
When was this opportunity posted and when did it close?
It was posted on February 2, 2010 and closed on March 31, 2010. The archive date listed is April 30, 2010.
What type of opportunity is it listed as?
It is listed as a discretionary opportunity.
What funding instruments are used under this opportunity?
The opportunity uses grant and cooperative agreement funding instruments.
What activity category does this opportunity fall under?
It is categorized under Science and Technology/Research and Development.
How many awards were anticipated and what was the estimated total funding level?
The program anticipated making about 20 awards, with an estimated total funding level of $2.4 million.
Is cost sharing or matching required?
No. The opportunity did not require cost sharing or matching.
Who was eligible to apply?
Eligibility was described as unrestricted, meaning it was open to many entity types unless further limited by additional eligibility language in the full announcement.
How competitive is this award based on the program history provided?
Since the award was introduced in FY03, 665 applications had been received and 115 were recommended for funding, indicating a selective program history.
Where can applicants get help accessing the full announcement or getting submission support?
The announcement points applicants to CDMRP help resources, including contacts for the full announcement and electronic submission support.
What are the contact details for PA HELP (full announcement/support)?
PA HELP can be reached at 301-619-7079 or by email at cdmrp.pa@amedd.army.mil.
What are the contact details for eReceipt HELP (electronic submission support)?
eReceipt HELP can be reached at 301-682-5507 or by email at help@cdmrp.org.
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