DoD Prostate Cancer Idea Development Award | Apply Online

Opportunity Summary:

The DoD Prostate Cancer Idea Development Award (Funding Opportunity Number W81XWH-12-PCRP-IDA) is a U.S. Department of Defense Congressionally Directed Medical Research Programs (CDMRP) funding opportunity administered by the Department of the Army through the U.S. Army Medical Research Acquisition Activity (USAMRAA). It is designed to push forward prostate cancer research by supporting bold, unconventional concepts that may be too early, too novel, or too risky for more traditional funding mechanisms, but that could produce major advances if successful. The overall purpose is to encourage research that could meaningfully contribute to reducing illness and preventing deaths from prostate cancer.

A key structural feature of this opportunity is that it uses a two-step submission process. A preproposal is required first, and only those applicants whose preproposals are selected will be invited to submit a full application. That invitation-only full submission stage means investigators need to treat the preproposal as the main gatekeeping step, clearly communicating what makes the idea genuinely innovative and why it could have an outsized impact on the field if it works. Preliminary or supporting data are encouraged but not required, which signals that the program is intentionally open to early-stage concepts; however, even without extensive data, applicants still need to present a persuasive scientific rationale and a credible plan to test the idea.

The award is explicitly aimed at "innovative, high risk/high gain" approaches. In practical terms, this means the program is interested in research that challenges existing assumptions, introduces new models or technologies, proposes fresh mechanisms, or applies methods from other disciplines to prostate cancer in a way that could change understanding or clinical direction later on. Review emphasis is heavily weighted toward Innovation and Impact, identified as the most important review criteria. Applicants should therefore prioritize explaining what is truly different about the approach, why it matters for prostate cancer specifically, and what kind of breakthrough knowledge, tool, or strategy might result if the project succeeds.

This funding opportunity does not support clinical trials, so projects must be structured accordingly. While the research can be translational in intent and may aim to lay groundwork for future clinical application, the proposed work itself should stop short of a clinical trial as defined by human interventional study designs. Applicants considering patient-derived samples, observational human studies, animal models, or laboratory-based validation should ensure their work fits within the announcement's non-clinical-trial boundaries.

An additional feature is the New Investigator Option, which is meant to support researchers early in their faculty appointments or those still building independent research careers. This option is intended to broaden participation and help emerging investigators establish themselves with an independent, innovative research direction in prostate cancer. While eligibility is listed as unrestricted (open to any type of entity, subject to any clarifications in the full announcement), the New Investigator Option provides a specific pathway or category that can be particularly relevant to early-career applicants.

From an administrative and funding standpoint, the opportunity was posted March 20, 2012, with an original and current closing date of August 9, 2012, and an archive date of September 8, 2012. The program anticipated approximately 30 awards with an estimated total funding amount of $14,900,000. The funding instrument type is listed as either a cooperative agreement or grant, and there is no cost sharing or matching requirement. The CFDA number associated with this opportunity is 12.420 (Military Medical Research and Development), reflecting its placement within the DoD medical R&D portfolio.

For applicants needing assistance obtaining or accessing the full announcement details, the listed point of contact is the CDMRP Help Desk at 301-682-5507.

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Previous opportunity: DoD Prostate Cancer Transformative Impact Award

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