Opportunity Information: Apply for W81XWH 13 PCRP PCPRNA
Apply for W81XWH 13 PCRP PCPRNA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Prostate Cancer Pathology Resource Network Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Jul 1, 2013 and posted on Jul 1, 2013.
- Applicants must submit their applications by Oct 9, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,600,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Prostate Cancer Pathology Resource Network Award (PCPRN) is a Department of the Army (USAMRAA) funding opportunity under the Congressionally Directed Medical Research Programs (CDMRP) Prostate Cancer Research Program. It is structured as a cooperative agreement intended to build and sustain shared research infrastructure rather than to fund a single, stand-alone research project. The central goal is to create a multi-institutional network that can reliably collect, process, annotate, store, and distribute high-quality human prostate cancer biospecimens, along with the supporting data needed to make those specimens broadly useful to the prostate cancer research community.
A major priority of the award is expanding access to rare or limited-supply specimen types that are often difficult for investigators to obtain but are critical for answering pressing questions in the field. While the network may collect specimens across the full range of prostate cancer stages, the emphasis is explicitly on scarce and high-value categories such as castration-resistant disease, metastatic disease, neuroendocrine phenotype tumors, samples from disproportionately affected populations, active surveillance cohorts, and longitudinally collected specimens. In addition to physical specimens, the network is expected to collect, store, and manage data derived from the distributed materials, including hematoxylin and eosin (H and E) slide images, so that researchers receiving specimens also have access to consistent pathology context and associated annotations.
The award requires a coordinated network design consisting of a single Coordinating Center plus four Pathology Resource Sites, with the Coordinating Center also serving as one of the Pathology Resource Sites. Together, these entities jointly design and operate the biorepository. The Coordinating Center acts as the hub for administration, operational oversight, and data management, and it supports the implementation of shared network policies and standard operating procedures across sites. The solicitation highlights that the Coordinating Center should bring multidisciplinary expertise and a strong track record running multi-institutional collaborations in prostate cancer research, and it encourages applicants that already have core capabilities in place, such as pathology and histochemistry infrastructure, biorepository equipment, and informatics systems that can support secure connectivity and data transfer between sites.
Each Pathology Resource Site is expected to contribute distinct strengths to the overall biorepository rather than duplicating the same capacity everywhere. Sites should be capable of producing derivative biomolecules like DNA, RNA, and proteins, and should be able to apply both standard and advanced processing technologies that enable a wide range of downstream studies, with examples including laser capture microdissection and tissue microarrays. The program allows and even encourages the inclusion of both U.S. and international organizations as part of the network. Because site contributions may legitimately differ, the funding distribution across sites can vary, but any significant variance is expected to be clearly justified in the budget narrative so reviewers understand why resources are weighted the way they are.
Applications must do more than list operational capabilities; they should explain how the resulting biorepository will help the broader research community address the Prostate Cancer Research Program (PCRP) overarching challenges and focus areas through access to network specimens and associated data. Applicants are also expected to propose a clearly defined mission that will guide what gets collected, how specimens are prioritized for distribution, and what data elements are captured and managed. Another important requirement is sustainability planning: institutions must show commitment and a realistic approach to securing additional funding from other sources to keep the network operating after the PCRP performance period ends, signaling that this is intended to be an enduring resource rather than a short-lived collection effort.
A notable structural change introduced for FY13 is that applications are submitted by Coordinating Centers in collaboration with their chosen Pathology Resource Sites, rather than as more separated submissions as in prior offerings. The solicitation also offers a Multiple PI Option to accommodate the multi-institutional structure. Under this option, up to four principal investigators may each receive separate awards instead of operating purely through subawards under one Coordinating Center award. The Coordinating Center PI serves as the Initiating PI, while other site PIs serve as Partnering PIs, and all related applications for the same proposed biorepository are linked through the CDMRP eReceipt system. The announcement notes practical tradeoffs with this approach, including reduced Coordinating Center direct-cost burden for supporting other sites indirect costs, increased government oversight of individual sites, and reduced flexibility if a site underperforms.
The award also encourages, but does not require, the recipients to organize a workshop during the period of performance to bring together network investigators, biorepository participants, and outside experts in biospecimen science. If included, the application should explain how the workshop would increase the biorepositorys usefulness and improve its ability to enable meaningful, innovative prostate cancer research, and the budget should include appropriate costs for that activity.
Key administrative details from the announcement include: Funding Opportunity Number W81XWH-13-PCRP-PCPRNA; CFDA 12.420 (Military Medical Research and Development); estimated total funding of $1,600,000 with an expected single award; no cost sharing or matching requirement; eligibility listed as unrestricted (open to any entity type, subject to any clarifications in the full text); and an original/current closing date of October 9, 2013 (posted July 1, 2013).
FAQs: DoD Prostate Cancer Pathology Resource Network Award (PCPRN)
What is the PCPRN Award?
The DoD Prostate Cancer Pathology Resource Network Award (PCPRN) is a Department of the Army (USAMRAA) funding opportunity under the Congressionally Directed Medical Research Programs (CDMRP) Prostate Cancer Research Program (PCRP). It is structured as a cooperative agreement focused on building and sustaining shared research infrastructure, rather than funding a single stand-alone research project.
What is the primary purpose of this award?
The central purpose is to create a multi-institutional network that can reliably collect, process, annotate, store, and distribute high-quality human prostate cancer biospecimens, along with the supporting data needed to make those specimens broadly useful to the prostate cancer research community.
Is this award intended to fund a single research study?
No. The solicitation emphasizes that the award is intended to build and sustain a shared biorepository and associated data resources for broad community use, rather than to support one independent research project.
What kind of infrastructure is the program trying to build?
The program aims to establish a coordinated biorepository network (a pathology resource network) that operates across multiple institutions and can consistently manage biospecimen collection, processing, pathology context, annotation, storage, and distribution, along with associated data management and secure data transfer between sites.
What specimen types are prioritized by the program?
A major priority is expanding access to rare or limited-supply specimen types that are difficult to obtain but critical for prostate cancer research. The announcement explicitly highlights high-value categories such as castration-resistant disease, metastatic disease, neuroendocrine phenotype tumors, samples from disproportionately affected populations, active surveillance cohorts, and longitudinally collected specimens.
Does the network only collect rare specimens?
No. The network may collect specimens across the full range of prostate cancer stages, but the stated emphasis is on scarce and high-value categories that are often limited in availability.
What data are expected to be collected and managed along with specimens?
In addition to physical specimens, the network is expected to collect, store, and manage data derived from distributed materials, including hematoxylin and eosin (H and E) slide images. The intent is that researchers receiving specimens also have access to consistent pathology context and associated annotations.
How is the required network structure organized?
The solicitation requires a coordinated design consisting of one Coordinating Center plus four Pathology Resource Sites. The Coordinating Center must also serve as one of the Pathology Resource Sites. Together, these entities jointly design and operate the biorepository.
What is the role of the Coordinating Center?
The Coordinating Center serves as the hub for administration, operational oversight, and data management. It supports implementation of shared network policies and standard operating procedures across all sites and is expected to bring multidisciplinary expertise and a strong track record in running multi-institutional prostate cancer research collaborations.
What capabilities does the announcement encourage for the Coordinating Center?
The solicitation encourages applicants that already have core capabilities in place, such as pathology and histochemistry infrastructure, biorepository equipment, and informatics systems that support secure connectivity and data transfer between sites.
What is the role of each Pathology Resource Site?
Each Pathology Resource Site is expected to contribute distinct strengths to the overall biorepository rather than duplicating identical capabilities at every site. The sites collectively support the network mission by providing complementary specimen processing, pathology, and biospecimen resource functions.
What technical processing capabilities are expected at Pathology Resource Sites?
Sites should be capable of producing derivative biomolecules such as DNA, RNA, and proteins. They should also be able to apply standard and advanced processing technologies to enable a wide range of downstream studies, with examples in the solicitation including laser capture microdissection and tissue microarrays.
Can the network include international organizations?
Yes. The program allows and encourages inclusion of both U.S. and international organizations as part of the network.
How should applicants address differences between sites?
Because site contributions may legitimately differ, the funding distribution across sites can vary. If there is significant variance in funding levels among sites, the budget narrative is expected to clearly justify the distribution so reviewers understand why resources are weighted as proposed.
What must applications explain beyond listing capabilities?
Applications are expected to explain how the biorepository will help the broader research community address the PCRP overarching challenges and focus areas through access to network specimens and associated data. In other words, the application should connect infrastructure plans to the needs of the prostate cancer research community.
Is a defined mission required for the proposed network?
Yes. Applicants are expected to propose a clearly defined mission that guides what gets collected, how specimens are prioritized for distribution, and what data elements are captured and managed.
Is sustainability planning part of the evaluation expectation?
Yes. The solicitation calls for sustainability planning, including institutional commitment and a realistic approach to securing additional funding from other sources to keep the network operating after the PCRP performance period ends. The stated intent is an enduring resource rather than a short-lived collection effort.
How did the submission structure change for FY13?
For FY13, the announcement notes a structural change: applications are submitted by Coordinating Centers in collaboration with their chosen Pathology Resource Sites, rather than as more separated submissions used in prior offerings.
What is the Multiple PI Option?
The solicitation offers a Multiple PI Option to accommodate the multi-institutional structure. Under this option, up to four principal investigators may each receive separate awards instead of operating purely through subawards under one Coordinating Center award. The Coordinating Center PI serves as the Initiating PI, and other site PIs serve as Partnering PIs.
How are Multiple PI applications connected?
All related applications for the same proposed biorepository are linked through the CDMRP eReceipt system, as described in the announcement.
What tradeoffs are noted for the Multiple PI Option?
The announcement describes practical tradeoffs, including reduced Coordinating Center direct-cost burden for supporting other sites indirect costs, increased government oversight of individual sites, and reduced flexibility if a site underperforms.
Is hosting a workshop required under this award?
No. The award encourages, but does not require, recipients to organize a workshop during the period of performance to convene network investigators, biorepository participants, and outside experts in biospecimen science.
If a workshop is proposed, what should the application include?
If included, the application should explain how the workshop would increase the biorepository's usefulness and improve its ability to enable meaningful, innovative prostate cancer research, and the budget should include appropriate costs for the workshop activity.
What is the Funding Opportunity Number for this solicitation?
The Funding Opportunity Number is W81XWH-13-PCRP-PCPRNA.
What CFDA number is associated with this opportunity?
The CFDA number listed is 12.420 (Military Medical Research and Development).
How much funding is expected to be available, and how many awards are anticipated?
The announcement estimates total funding of $1,600,000 and states an expected single award.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is listed as unrestricted (open to any entity type), subject to any clarifications in the full text of the announcement.
What was the closing date listed in the announcement?
The original/current closing date listed is October 9, 2013. The announcement was posted July 1, 2013.
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