DoD Prostate Cancer Synergistic Idea Development Award | Apply Online

Opportunity Summary:

The DoD Prostate Cancer Synergistic Idea Development Award is a funding opportunity under the Department of the Army's Congressionally Directed Medical Research Programs (CDMRP), specifically within the Prostate Cancer Research Program (PCRP). Its main purpose is to push prostate cancer research forward faster by backing genuinely new, high-impact ideas that come from close collaboration among two or three independent, faculty-level (or equivalent) principal investigators. The award is built around the idea that major breakthroughs often happen when experts from different backgrounds combine their strengths to tackle one shared, clearly defined problem in a way that would not be possible if each lab worked separately.

A defining feature of this mechanism is the emphasis on synergy. The investigators are expected to co-create a single, integrated research project with comparable intellectual leadership from each PI. While the project is shared, each PI is treated as a full principal investigator, submits a separate application package (even if all investigators are at the same institution), and receives an individual award. Reviewers are looking for projects where each PI brings unique expertise, tools, or perspectives that are essential to the overall approach, and where the collaborative structure clearly accelerates progress beyond what independent or loosely coordinated projects could achieve.

The program strongly prioritizes innovation. That means the proposed work should introduce a new paradigm, challenge existing assumptions, reframe a known problem in a creative way, or apply a novel method or cross-disciplinary strategy to prostate cancer research. Incremental extensions of already published work are explicitly not the goal. At the same time, the PCRP recognizes that innovative science can carry risk, so while preliminary data relevant to prostate cancer is encouraged, it is not required. Applicants still need to show that the concept is grounded in a solid scientific rationale, supported by logical reasoning and/or a thoughtful analysis of the existing literature.

In terms of scientific scope, the opportunity is intentionally broad and welcomes investigators from many disciplines, including basic science, engineering, bioinformatics, population science, translational research, and clinical research (with limits described below). Applicants are expected to address at least one of the PCRP focus areas and are strongly encouraged to address one of the PCRP overarching challenges. If a team chooses not to address an overarching challenge, the application is expected to clearly explain why the work still fills a critical gap for the field and/or improves patient care in a meaningful way.

Collaboration planning is not treated as an afterthought. Each proposed study must include clear, practical plans for how the investigators will interact and manage the collaboration, including communication routines, coordination of research activities, sharing of results, and data transfer. For multi-institutional collaborations, the program also requires an intellectual property plan. The point is to anticipate and resolve potential institutional barriers around intellectual and material property so that the partnership can operate smoothly and at a high level of cooperation throughout the award period.

Human subjects research is allowed, but clinical trials are not permitted under this mechanism. The opportunity does, however, encourage correlative studies tied to an existing clinical trial, as long as those correlative activities are judged to be no greater than minimal risk by the local IRB of record and by the USAMRMC Office of Research Protections (including HRPO review). The announcement also points applicants to a Human Subject Resource Document housed in the CDMRP eBRAP system for program-specific definitions and guidance around what counts as clinical research versus a clinical trial.

The PCRP also encourages teams to leverage existing PCRP-supported resources when relevant, particularly the Prostate Cancer Biorepository Network (PCBN) and the North Carolina-Louisiana Prostate Cancer Project (PCaP), especially when retrospectively collected human specimens or associated datasets could strengthen the proposed work. Beyond conducting the research itself, the CDMRP signals a strong expectation that data and research resources generated through funded awards should be shared with the wider research community (including consumer advocacy communities) and, broadly, the public, consistent with CDMRP guidance.

For the specific FY14 posting described, the opportunity was listed as Funding Opportunity Number W81XWH-14-PCRP-SIDA and was offered as a cooperative agreement/grant under CFDA 12.420 (Military Medical Research and Development). The program anticipated making about 18 awards with an estimated total funding level of $10.8 million, and it did not require cost sharing or matching funds. Eligibility was listed as unrestricted (open broadly to entity types, subject to any additional eligibility clarifications in the full announcement). The opportunity was posted May 6, 2014, with an application closing date of September 24, 2014, and it was archived October 24, 2014.

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