Opportunity Information: Apply for W81XWH 16 SCIRP TRA

  • The DOD-AMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Spinal Cord Injury Translational Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
  • This funding opportunity was created on May 13, 2016 and posted on May 13, 2016.
  • Applicants must submit their applications by Sep 21, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The number of recipients for this funding is limited to 3 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:

The DoD Spinal Cord Injury Translational Award (SCIRP TRA) is a U.S. Department of Defense funding opportunity designed to push spinal cord injury (SCI) research beyond early discovery and into work that can realistically lead to clinical use. The program is centered on translational research, meaning studies that take a promising observation or concept and move it toward practical healthcare applications such as new therapeutics, medical devices, or evidence-based practices and guidelines. The emphasis is on accelerating progress so that patients can benefit sooner, not simply generating additional basic science knowledge without a clear pathway to clinical impact.

A key feature of this award is the type of research it supports. Example projects include preclinical demonstration studies for pharmaceuticals or medical devices, as well as clinical research that evaluates therapeutics, devices, or care practices using human tissues, clinical resources, or other human-based materials and data. In other words, applicants are expected to propose work that connects directly to clinical relevance, whether by strengthening preclinical evidence needed for human studies, validating a technology or intervention in realistic models, or conducting clinical investigations that can inform patient care.

The program also highlights how translational ideas can originate. A compelling premise may come from a laboratory finding, population-based research, or a clinician's direct experience with patients, including practical observations and anecdotal patterns that suggest a new direction worth testing. At the same time, the opportunity makes an important point about how translation should be approached: it is not meant to be a simple, one-way pipeline from bench to bedside. Instead, proposals should reflect a two-way, iterative exchange between basic and clinical science, where clinical needs and real-world observations inform experimental work, and experimental results loop back to refine clinical questions and applications.

Administratively, this opportunity was issued by DOD-AMRAA under Funding Opportunity Number W81XWH-16-SCIRP-TRA. It falls under the Science and Technology and other Research and Development category and is associated with CFDA 12.420. The funding instrument types listed are both cooperative agreements and grants, which generally indicates that some awards may involve more active program involvement from the sponsor (cooperative agreement) while others may operate more like traditional grant support, depending on the specific project and award mechanism. Eligibility is described as unrestricted, meaning the opportunity was broadly open to many entity types, subject to any clarifications in the full announcement. The posting date was May 13, 2016, with a closing date of September 21, 2016, and the program anticipated making about three awards.

DoD Spinal Cord Injury Translational Award (SCIRP TRA) - FAQs

1. What is the DoD Spinal Cord Injury Translational Award (SCIRP TRA)?

The SCIRP Translational Award (TRA) is a U.S. Department of Defense funding opportunity focused on moving spinal cord injury (SCI) research beyond early discovery and into work that can realistically lead to clinical use. The central goal is to accelerate progress so patients can benefit sooner.

2. What does "translational research" mean in this program?

In this opportunity, translational research means taking a promising observation or concept and advancing it toward practical healthcare applications. Examples of applications mentioned include new therapeutics, medical devices, or evidence-based practices and guidelines that could inform clinical care.

3. What kinds of projects are a good fit for this award?

The program highlights projects that connect directly to clinical relevance, including:

  • Preclinical demonstration studies for pharmaceuticals
  • Preclinical demonstration studies for medical devices
  • Clinical research evaluating therapeutics, devices, or care practices using human tissues, clinical resources, or other human-based materials and data

4. What kinds of outcomes is the program trying to accelerate?

The award emphasizes outcomes that move toward clinical impact, such as interventions and tools that could be used in patient care (therapeutics, devices) and evidence that can support evidence-based practices and guidelines. The focus is on progressing toward real-world use rather than producing basic science findings without a clear clinical pathway.

5. Does the program support basic science research?

The opportunity is centered on translational research and emphasizes that the work should have a clear pathway to clinical impact. It specifically notes that the focus is not simply generating additional basic science knowledge without a clear route to practical benefit.

6. Can proposals include clinical research using human-based materials and data?

Yes. The description explicitly includes clinical research that evaluates therapeutics, devices, or care practices using human tissues, clinical resources, or other human-based materials and data.

7. Can proposals focus on strengthening preclinical evidence needed for human studies?

Yes. The program describes preclinical demonstration studies for pharmaceuticals or medical devices and indicates that applicants are expected to propose work that strengthens evidence needed to move toward clinical relevance and potential human studies.

8. Where can a strong translational premise come from?

The opportunity notes that translational ideas can originate from several sources, including:

  • A laboratory finding
  • Population-based research
  • A clinician's direct experience with patients, including practical observations and anecdotal patterns

9. Is translation described as a one-way "bench to bedside" pipeline?

No. The program emphasizes that translation is not meant to be a simple, one-way pipeline. Instead, proposals should reflect a two-way, iterative exchange between basic and clinical science, where clinical needs inform experimental work and experimental results loop back to refine clinical questions and applications.

10. Who issued this funding opportunity?

The opportunity was issued by DOD-AMRAA.

11. What is the Funding Opportunity Number for this award?

The Funding Opportunity Number is W81XWH-16-SCIRP-TRA.

12. What category does this opportunity fall under?

It falls under the Science and Technology and other Research and Development category.

13. What CFDA number is associated with this opportunity?

The opportunity is associated with CFDA 12.420.

14. What funding instrument types are listed for this award?

The listed funding instrument types are cooperative agreements and grants. This generally indicates that some awards may involve more active program involvement from the sponsor (cooperative agreement), while others may function more like traditional grant support (grant), depending on the specific project and mechanism.

15. What does "unrestricted eligibility" mean for this opportunity?

Eligibility is described as unrestricted, meaning the opportunity was broadly open to many entity types, subject to any clarifications in the full announcement.

16. When was this opportunity posted?

The posting date was May 13, 2016.

17. What was the closing date for this opportunity?

The closing date was September 21, 2016.

18. About how many awards were anticipated?

The program anticipated making about three awards.

19. What is the overall focus area of the program?

The overall focus is spinal cord injury (SCI) research, specifically research that can be translated into practical clinical use such as therapeutics, devices, or evidence-based care practices and guidelines.

20. How should applicants demonstrate clinical relevance in their proposal?

Based on the description, applicants are expected to propose work that connects directly to clinical relevance. This could include validating an intervention or technology in realistic models, strengthening the preclinical evidence needed to move toward human application, or conducting clinical investigations using human-based materials and data to inform patient care.

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