Opportunity Information: Apply for W81XWH 12 SCIRP TRA
Apply for W81XWH 12 SCIRP TRA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Spinal Cord Injury Translational Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Jul 3, 2012 and posted on May 31, 2012.
- Applicants must submit their applications by Oct 1, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,400,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Spinal Cord Injury Translational Research Award (TRA) is a funding opportunity from the U.S. Army Medical Research Acquisition Activity (USAMRAA) under the Congressionally Directed Medical Research Programs (CDMRP). Its purpose is to support translational spinal cord injury (SCI) research that moves promising ideas closer to real clinical use, with an emphasis on projects that actively connect basic science and clinical realities rather than treating translation as a simple one-way path from lab findings to patient care.
A key change highlighted in this announcement is that, starting in FY12, the mechanism was redesigned to support individual investigators. Earlier versions of the program (previously called the Translational Research Partnership Award, TRPA) were geared toward multi-institutional, multidisciplinary partnerships among clinicians and basic scientists. Under the FY12 TRA structure, those collaborations can still be valuable, but they are no longer a requirement. This opens the door for a single principal investigator to propose a strong, clinically relevant translational plan, as long as the work clearly demonstrates meaningful integration between basic and clinical perspectives.
The program frames translational research broadly in terms of where ideas can originate. A proposal can be driven by laboratory discoveries, population-based studies, or a clinician's firsthand observations from patient care, including anecdotal patterns that suggest a testable opportunity. At the same time, the award stresses that translation should involve a reciprocal exchange of information between the laboratory and the clinic. In practical terms, this means the research plan should show how clinical needs, clinical data, or patient observations influence experimental design, and how experimental findings then feed back into clinically relevant next steps. The announcement points applicants to general "pathways to clinical goals" materials (hosted by the National Cancer Institute) as an example framework for designing translational development plans.
Applications must include preliminary data that are relevant both to spinal cord injury and to the specific proposed project. This requirement signals that the award is intended for ideas that already have a foundation strong enough to justify a translational push, rather than purely exploratory concepts without SCI-relevant supporting evidence.
Human subjects research and work involving human anatomical substances are allowed, but clinical trials are explicitly not permitted under this mechanism. The announcement uses a specific definition of a clinical trial: prospective enrollment of human participants in which an intervention is tested (such as a drug, biologic, device, surgery, rehabilitation modality, behavioral intervention, or similar approach) and outcomes are measured for exploratory information, safety, effectiveness, or efficacy, reflecting a direct effect of the intervention on the participant. Investigators intending to run a clinical trial are directed instead to the FY12 SCIRP Clinical Trial Award mechanism (W81XWH-12-SCIRP-CTA). Additional guidance on human subjects and how CDMRP distinguishes clinical research from clinical trials is provided through a Human Subject Resource Document available in the CDMRP eReceipt system.
From an administrative and funding standpoint, this opportunity (Funding Opportunity Number W81XWH-12-SCIRP-TRA) is categorized as discretionary funding and supports science and technology research and development. The funding instrument type is listed as a cooperative agreement/grant, with no cost sharing or matching requirement. Eligibility is described as unrestricted, meaning it is broadly open to many types of applicant organizations, subject to any clarifications in the full announcement. The DoD anticipated making about two awards, with an estimated total funding amount of $2.4 million. The opportunity was posted May 31, 2012, and the application deadline was October 1, 2012 (with the opportunity archived at the end of that month). For access or technical issues with the full announcement, applicants were instructed to contact the CDMRP Help Desk.
Frequently Asked Questions (FAQs)
What is the DoD Spinal Cord Injury Translational Research Award (TRA)?
The DoD Spinal Cord Injury Translational Research Award (TRA) is a funding opportunity administered by the U.S. Army Medical Research Acquisition Activity (USAMRAA) under the Congressionally Directed Medical Research Programs (CDMRP). It supports translational spinal cord injury (SCI) research intended to move promising ideas closer to real clinical use.
What is the main purpose of this award?
The purpose is to advance translational SCI research in a way that meaningfully connects basic science and clinical realities. The program emphasizes translation as an interactive, two-way exchange between the laboratory and the clinic, rather than a simple one-direction path from lab discovery to patient care.
What does the program mean by "translational" research?
In this opportunity, translational research is framed broadly. Ideas can originate from laboratory discoveries, population-based studies, or clinical observations from patient care (including anecdotal patterns that suggest a testable opportunity). The key expectation is a reciprocal exchange: clinical needs and clinical data should shape experimental design, and experimental results should feed back into clinically relevant next steps.
How should applicants show the "two-way" nature of translation in their proposal?
Applicants are expected to demonstrate how clinical needs, clinical observations, or clinical data influence the research plan and experimental approach, and how resulting findings will inform clinically relevant development steps. The announcement points to general "pathways to clinical goals" materials (hosted by the National Cancer Institute) as an example framework for designing translational development plans.
Is this award intended for single investigators or partnerships?
Starting in FY12, the mechanism was redesigned to support individual investigators. Earlier versions of the program (previously called the Translational Research Partnership Award, TRPA) emphasized multi-institutional, multidisciplinary partnerships among clinicians and basic scientists. Under the FY12 TRA structure, collaborations may still be valuable, but they are not required.
Do collaborations between clinicians and basic scientists still matter?
Yes. While not required under the FY12 TRA structure, collaborations can still strengthen a proposal. The essential requirement is that the work clearly demonstrates meaningful integration between basic and clinical perspectives.
Is preliminary data required?
Yes. Applications must include preliminary data that are relevant to spinal cord injury and relevant to the proposed project. This indicates the program is intended for projects with an SCI-relevant foundation strong enough to justify a translational push, rather than purely exploratory ideas without supporting evidence tied to SCI.
Are human subjects studies allowed?
Yes. Human subjects research is allowed under this mechanism.
Is research involving human anatomical substances allowed?
Yes. Work involving human anatomical substances is allowed.
Are clinical trials allowed under this award?
No. Clinical trials are explicitly not permitted under this mechanism.
How does this opportunity define a "clinical trial"?
The announcement defines a clinical trial as prospective enrollment of human participants where an intervention is tested (for example, a drug, biologic, device, surgery, rehabilitation modality, behavioral intervention, or similar approach) and outcomes are measured for exploratory information, safety, effectiveness, or efficacy, reflecting a direct effect of the intervention on the participant.
If an investigator wants to run a clinical trial, where should they apply instead?
Investigators intending to run a clinical trial are directed to the FY12 SCIRP Clinical Trial Award mechanism (W81XWH-12-SCIRP-CTA).
Where can applicants find additional guidance on human subjects and the clinical research vs. clinical trial distinction?
Additional guidance is available in a Human Subject Resource Document provided through the CDMRP eReceipt system, including how CDMRP distinguishes clinical research from clinical trials.
What is the Funding Opportunity Number for this award?
The Funding Opportunity Number listed for this announcement is W81XWH-12-SCIRP-TRA.
What type of funding is this considered?
The opportunity is categorized as discretionary funding and supports science and technology research and development.
What is the funding instrument type?
The funding instrument type is listed as a cooperative agreement/grant.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is described as unrestricted, meaning it is broadly open to many types of applicant organizations, subject to any clarifications in the full announcement.
How many awards did the DoD anticipate making, and what was the estimated total funding?
The DoD anticipated making about two awards, with an estimated total funding amount of $2.4 million.
When was the opportunity posted and when was the application deadline?
The opportunity was posted on May 31, 2012. The application deadline was October 1, 2012. The opportunity was archived at the end of October 2012.
Who administers this opportunity?
This funding opportunity is from USAMRAA under CDMRP.
What should applicants do if they have trouble accessing the full announcement or experience technical issues?
For access or technical issues with the full announcement, applicants were instructed to contact the CDMRP Help Desk.
Does the award restrict where translational ideas can originate?
No. The program explicitly notes that proposals may be driven by laboratory findings, population-based studies, or clinician observations from patient care, as long as the approach is translational and integrates basic and clinical perspectives.
Does this award require multi-institutional participation?
No. Under the FY12 TRA redesign, multi-institutional, multidisciplinary partnerships are not required, even though they were a defining feature of the earlier TRPA mechanism.
What is the earlier name of this program mechanism?
Earlier versions were called the Translational Research Partnership Award (TRPA).
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| EPSCoR Research Infrastructure Improvement Program Track 1 Apply for 12 563 Funding Number: 12 563 Agency: National Science Foundation Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Spinal Cord Injury Investigator Initiated Research Award Apply for W81XWH 12 SCIRP IIRA Funding Number: W81XWH 12 SCIRP IIRA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DOD Spinal Cord Injury Clinical Trial Award Apply for W81XWH 12 SCIRP CTA Funding Number: W81XWH 12 SCIRP CTA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
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| DOD FY12 Duchenne Muscular Dystrophy Therapeutic Idea Award Apply for W81XWH 12 DMDRP TIA Funding Number: W81XWH 12 DMDRP TIA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DOD FY12 Duchenne Muscular Dystrophy Investigator Initiated Research Award Apply for W81XWH 12 DMDRP IIRA Funding Number: W81XWH 12 DMDRP IIRA Agency: Dept. of the Army USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
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