Opportunity Information: Apply for W81XWH 12 PHTBI TBIRA

  • The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Traumatic Brain Injury Research Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
  • This funding opportunity was created on Oct 4, 2012 and posted on Aug 10, 2012.
  • Applicants must submit their applications by Dec 3, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $4,800,000.00 to eligible and selected applicants.
  • The number of recipients for this funding is limited to 5 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
Apply for W81XWH 12 PHTBI TBIRA

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Opportunity Summary:

The DoD Traumatic Brain Injury Research Award (TBIRA) is a Department of Defense funding opportunity run through the U.S. Army Medical Research Acquisition Activity (USAMRAA) under the Military Medical Research and Development program (CFDA 12.420). It is designed to support targeted traumatic brain injury (TBI) research that focuses on generating knowledge and answering specific, well-defined scientific questions. The emphasis is on early-stage, new, or unconventional ideas that have not yet been fully developed but could produce high-impact data and open up promising new directions for the broader TBI research field.

A central feature of this mechanism is that it does not allow clinical trials. In other words, applicants are expected to propose research that builds understanding, tests concepts, and establishes feasibility rather than conducting trial-based evaluations of interventions in a clinical trial framework. The award is meant to advance scientific understanding of TBI-related phenomena and behaviors, strengthen or refine theoretical constructs tied to defined TBI research areas of interest, and encourage investigators to propose new paradigms or challenge existing ones when supported by a strong rationale.

Within that knowledge-building scope, the program also welcomes studies that assess the technical feasibility of emerging solutions. This includes exploratory work on potential products and technologies, pharmacologic agents, behavioral and rehabilitation interventions, diagnostic and therapeutic techniques, and clinical guidance approaches. The underlying goal is to generate credible, decision-shaping data that can justify and inform later-stage development or follow-on research, rather than to complete late-stage validation through clinical trials.

Administratively, the opportunity was posted on August 10, 2012, with an original closing date of November 26, 2012, later extended to December 3, 2012, and archived on December 26, 2012. The estimated total funding was $4.8 million, with an anticipated five awards. Funding could be made as either a grant or a cooperative agreement, and there was no cost sharing or matching requirement. Eligibility was listed as unrestricted, meaning it was broadly open to applicant types, subject to any additional eligibility clarifications contained in the full announcement.

For applicant support or trouble accessing the full announcement, the contact point listed is the CDMRP Help Desk at 301-682-5507 or help@cdmrp.org.

DoD Traumatic Brain Injury Research Award (TBIRA) - FAQs

1) What is the DoD Traumatic Brain Injury Research Award (TBIRA)?

The TBIRA is a U.S. Department of Defense (DoD) funding opportunity administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA) under the Military Medical Research and Development program (CFDA 12.420). It supports targeted traumatic brain injury (TBI) research intended to generate knowledge and answer specific, well-defined scientific questions.

2) What is the main goal of this award?

The main goal is to advance scientific understanding of TBI-related phenomena and behaviors by generating credible, decision-shaping data. The mechanism is aimed at building understanding, testing concepts, and establishing feasibility in ways that can inform follow-on research and later-stage development.

3) What kind of research is this award designed to support?

This award is designed to support targeted research that focuses on answering specific scientific questions in traumatic brain injury. It emphasizes early-stage, new, or unconventional ideas that have not yet been fully developed, but that could produce high-impact data and open up promising new directions for the broader TBI research field.

4) Is the TBIRA focused on early-stage or late-stage research?

The emphasis is on early-stage work, including new or unconventional ideas that are not yet fully developed. The goal is to generate data that can justify and inform subsequent development or follow-on research, rather than completing late-stage validation.

5) Are clinical trials allowed under this award?

No. A central feature of the TBIRA mechanism is that it does not allow clinical trials. Applicants are expected to propose research that builds understanding, tests concepts, and establishes feasibility rather than conducting trial-based evaluations of interventions within a clinical trial framework.

6) If clinical trials are not allowed, what can applicants propose instead?

Applicants are expected to propose studies that generate knowledge and address well-defined scientific questions. This includes research that advances understanding of TBI-related phenomena and behaviors, strengthens or refines theoretical constructs tied to defined TBI research areas of interest, and proposes new paradigms or challenges existing ones when supported by a strong rationale.

7) Does the program support feasibility or exploratory testing of new solutions?

Yes. Within the knowledge-building scope, the program welcomes studies that assess the technical feasibility of emerging solutions. The intent is to produce credible data that can shape decisions and inform later-stage development or follow-on research.

8) What types of solutions or approaches may be explored for technical feasibility?

The program description includes exploratory work on potential products and technologies, pharmacologic agents, behavioral and rehabilitation interventions, diagnostic and therapeutic techniques, and clinical guidance approaches, as long as the work stays within the non-clinical-trial boundaries of the mechanism.

9) What kind of impact is the program trying to achieve?

The award is intended to produce high-impact data that advances understanding in TBI research and can open up promising new directions for the field. It also encourages investigators to propose new paradigms or challenge existing ones when supported by a strong rationale.

10) Who administers or runs this funding opportunity?

The opportunity is run through USAMRAA under the DoD Military Medical Research and Development program. The help desk listed for applicant support is the CDMRP Help Desk.

11) What is the CFDA number associated with this program?

The program is listed under CFDA 12.420.

12) What was the estimated total funding for this opportunity?

The estimated total funding was $4.8 million.

13) How many awards were anticipated?

The opportunity anticipated five awards.

14) What funding instrument types could be used for awards?

Funding could be made as either a grant or a cooperative agreement.

15) Is cost sharing or matching required?

No. There was no cost sharing or matching requirement listed.

16) Who was eligible to apply?

Eligibility was listed as unrestricted, meaning it was broadly open to applicant types, subject to any additional eligibility clarifications contained in the full announcement.

17) When was the opportunity posted?

The opportunity was posted on August 10, 2012.

18) What was the original closing date and was it extended?

The original closing date was November 26, 2012. It was later extended to December 3, 2012.

19) When was the opportunity archived?

The opportunity was archived on December 26, 2012.

20) Where can applicants get help or request access to the full announcement?

For applicant support or trouble accessing the full announcement, the listed contact is the CDMRP Help Desk at 301-682-5507 or help@cdmrp.org.

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