DoD Tuberous Sclerosis Complex Exploration Hypothesis Development Award | Apply Online

Opportunity Summary:

The DoD Tuberous Sclerosis Complex Exploration Hypothesis Development Award (EHDA) is a Department of the Army (USAMRAA) funding opportunity designed to kick start early stage, bold research ideas in the tuberous sclerosis complex (TSC) field. Its main purpose is to support the first round of investigation for concepts that are considered high risk but potentially high reward, meaning the work may be uncertain or exploratory in the short term yet capable of producing major advances or opening entirely new directions for TSC research. The projects funded under this mechanism are expected to serve as a foundation for later, more expansive studies, rather than representing a final, fully mature research program.

A central requirement of the EHDA is a clearly stated, well formulated, and testable hypothesis. Applicants are expected to ground that hypothesis in a strong scientific rationale and propose an appropriate study design that can realistically evaluate the idea being put forward. While preliminary data and/or published supporting evidence are encouraged and can strengthen the case that the idea is scientifically sound, they are not required. This is important because the award is meant to enable the exploration of promising concepts that may not yet have a large evidence base.

Innovation is the core standard by which proposals are expected to distinguish themselves. The program is looking for research that genuinely pushes beyond routine next steps and instead does things like introduce a new paradigm, challenge an existing assumption in the field, reframe a known problem from a different angle, or apply highly creative approaches that could change how TSC is studied or addressed. By contrast, work that mainly extends prior published findings in a straightforward, incremental way is explicitly described as not consistent with the intent of this award. Because innovation can be interpreted differently across subfields, the opportunity places responsibility on the Principal Investigator to spell out, in direct and specific terms, what makes the proposed work innovative within the context of TSC research and why it matters.

Administratively, this opportunity was issued as Funding Opportunity Number W81XWH-15-TSCRP-EHDA under CFDA 12.420 (Military Medical Research and Development). The funding instrument type listed is both cooperative agreement and grant, and the activity category is science and technology and other research and development. The DoD expected to make about four awards, and there was no cost sharing or matching requirement. Eligibility was listed as unrestricted, meaning it was broadly open to different types of applicant organizations, subject to any additional eligibility clarifications in the full announcement. The announcement was posted on May 6, 2015, with an original and current closing date of July 27, 2015, and an archive date of August 26, 2015. For access issues or announcement support, the contact point provided was the CDMRP Help Desk at 301-682-5507.

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