DOD Tuberous Sclerosis Complex Exploration Hypothesis Development Award | Apply Online

Opportunity Summary:

The DOD Tuberous Sclerosis Complex Research Program (TSCRP) Exploration - Hypothesis Development Award (EHDA) is a FY2009 funding opportunity from the Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA), aimed at jump-starting early-stage, high-risk research ideas in tuberous sclerosis complex (TSC). This mechanism was offered for the first time in FY09 and is specifically positioned to help investigators test bold, unproven concepts that could open up new directions in TSC research. The central goal is not to fund mature projects with extensive prior evidence, but to enable the initial exploration of innovative and potentially groundbreaking approaches that might otherwise be difficult to support through more conventional grant mechanisms.

The award is designed around the idea of "high risk, high gain." Applicants are expected to propose research that is genuinely novel and exploratory, including ideas that may not yet have a fully developed evidence base. The opportunity explicitly recognizes that, because the work is intended to explore untested concepts, there may be gaps in the supporting rationale due to limited available information. In practical terms, this means an application does not need to be backed by a large body of preliminary results, as would often be required for traditional hypothesis-driven funding. Preliminary data are encouraged when available, but they are not required, which lowers the barrier for pursuing new observations or early leads that have not yet been thoroughly validated.

A key emphasis of the EHDA is the development of scientific rationale for future work. The expected outcome is that results generated under this award will either help form the basis of a new hypothesis or provide initial principles that support an innovative hypothesis. The program also notes that it is meant to give investigators room to follow serendipitous observations, meaning unexpected findings or promising patterns that arise from ongoing research and suggest a new avenue worth investigating. In the application, the Principal Investigator is responsible for clearly explaining what is innovative about the proposed work and why it could matter for TSC, including the potential impact if the exploratory concept proves successful.

From an administrative standpoint, the opportunity was posted on February 2, 2009, with an application closing date of April 14, 2009, and an archive date of May 14, 2009. The funding instrument type listed includes both cooperative agreements and grants, and the activity category is science and technology and other research and development. The program anticipated making about five awards, supported by an estimated total funding amount of $750,000. There is no cost-sharing or matching requirement, which means applicants are not required to contribute additional funds to be eligible.

Eligibility is described as unrestricted, meaning it is open to any type of entity, subject to any additional limitations that might be described in the full program announcement. The CFDA number associated with the opportunity is 12.420 (Military Medical Research and Development), placing it within the broader portfolio of DOD medical research support. For applicants who needed assistance accessing the full announcement or navigating submission and electronic receipt systems, the notice provides help contacts, including PA HELP and the CDMRP helpdesk email and phone lines.

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