Opportunity Information: Apply for W81XWH 10 TSCRP IDA

  • The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Tuberous Sclerosis Complex Idea Development Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
  • This funding opportunity was created on Feb 16, 2010 and posted on Feb 16, 2010.
  • Applicants must submit their applications by May 6, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $2,100,000.00 to eligible and selected applicants.
  • The number of recipients for this funding is limited to 3 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
Apply for W81XWH 10 TSCRP IDA

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Opportunity Summary:

The DoD Tuberous Sclerosis Complex Idea Development Award (IDA) is a research grant opportunity under the Tuberous Sclerosis Complex Research Program (TSCRP) managed by the U.S. Army Medical Research Acquisition Activity (USAMRAA). It is designed to support high-impact, genuinely innovative projects that can move the TSC field forward in meaningful ways, either by advancing scientific understanding or by improving patient care. The program emphasizes originality and the potential to shift how TSC is studied or treated, rather than supporting small, incremental extensions of prior published work.

A central theme of this award is impact. Proposed projects are expected to substantially influence the concepts, approaches, or methods that drive TSC research, with a clear line of sight to why the work matters for the field and, ideally, for people living with tuberous sclerosis complex. Reviewers are looking for proposals that can produce important and original contributions, not just confirmatory studies or minor refinements of established ideas.

Innovation is another core requirement. The announcement makes it clear that “innovative” can take several forms: introducing a new paradigm, challenging an existing one, approaching an old problem from a new angle, or applying unusually creative methods. Innovation can show up in the research question, the methodology, the technology used, or even in how existing tools are adapted to solve a TSC-relevant problem. However, the opportunity explicitly draws a line against projects that amount to incremental progress on already published work, signaling that applicants need to demonstrate what is truly new and field-shifting about their approach.

Unlike some early-concept awards, this mechanism requires preliminary data. Applicants must include relevant preliminary findings generated by the principal investigator, the research team, or a collaborator. That requirement signals that while the award supports bold ideas, it still expects enough evidence to show feasibility and to justify why the proposed direction is worth investing in.

Human subjects research is allowed, but clinical trials are not. The notice defines a clinical trial in practical terms: a prospective study where an intervention (such as a drug, device, behavioral strategy, surgical procedure, or similar) is tested in human subjects with measurable outcomes. If a project meets that definition, it does not fit this funding mechanism; investigators are directed instead to use the separate Clinical Research Award mechanism. The announcement also points applicants to the program’s general application instructions (including Appendix 5) for additional rules and expectations related to human subjects, human data, or human anatomical materials.

From an administrative and funding standpoint, this opportunity was posted on February 16, 2010, with an application closing date of May 6, 2010, and an archive date of June 5, 2010. It is a discretionary funding opportunity offered as a cooperative agreement grant in the science and technology/research and development category. The anticipated number of awards was three, with an estimated total funding level of $2.1 million. The CFDA listing associated with it is 12.420 (Military Medical Research and Development). Cost sharing or matching was not required, and eligibility was listed as unrestricted, meaning it was open to any applicant entity type unless further limited by additional eligibility language in the full announcement.

For logistical support, the announcement provides contact points for help accessing the announcement and for electronic submission assistance through the CDMRP help desk channels, reflecting that it ran through the DoD’s standard CDMRP infrastructure for biomedical research funding.

DoD Tuberous Sclerosis Complex Idea Development Award (IDA): FAQs

What is the DoD Tuberous Sclerosis Complex Idea Development Award (IDA)?

The Idea Development Award (IDA) is a research grant opportunity under the Tuberous Sclerosis Complex Research Program (TSCRP) managed by the U.S. Army Medical Research Acquisition Activity (USAMRAA). It is intended to support high-impact, genuinely innovative research projects that can move the tuberous sclerosis complex (TSC) field forward in meaningful ways.

What is the main purpose of this award?

The award is designed to fund projects that substantially influence the concepts, approaches, or methods that drive TSC research, either by advancing scientific understanding or improving patient care. The program emphasizes work that can shift how TSC is studied or treated, rather than incremental extensions of already published research.

What does the program mean by “impact”?

Impact refers to the expected significance of the proposed work for the TSC field. Projects are expected to have a clear line of sight to why the work matters and how it could meaningfully affect TSC research directions and, ideally, outcomes or care for people living with TSC. Reviewers are looking for important and original contributions rather than confirmatory studies or minor refinements.

How does the program define “innovation” for this opportunity?

Innovation can include introducing a new paradigm, challenging an existing one, approaching an old problem from a new angle, or applying unusually creative methods. Innovation may be demonstrated through the research question, methodology, technology, or novel adaptation of existing tools to solve a TSC-relevant problem.

Are incremental or follow-on projects competitive for this award?

The opportunity explicitly discourages projects that amount to small, incremental progress on already published work. Applicants are expected to demonstrate what is truly new, original, and potentially field-shifting about the proposed approach.

Is preliminary data required?

Yes. Applicants must include relevant preliminary findings generated by the principal investigator, the research team, or a collaborator. This requirement indicates that the program supports bold ideas but still expects evidence of feasibility to justify investment in the proposed direction.

Can preliminary data come from collaborators?

Yes. The announcement states that relevant preliminary findings may be generated by the principal investigator, the research team, or a collaborator.

Is human subjects research allowed under this funding mechanism?

Yes. Human subjects research is permitted under this award.

Are clinical trials allowed under this award?

No. Clinical trials are not allowed under this funding mechanism. If a proposed study meets the notice’s definition of a clinical trial, it does not fit this award and investigators are directed to use the separate Clinical Research Award mechanism.

How does the notice describe a “clinical trial” for eligibility purposes?

The notice describes a clinical trial as a prospective study in which an intervention (for example, a drug, device, behavioral strategy, surgical procedure, or similar intervention) is tested in human subjects with measurable outcomes.

Where can applicants find additional requirements for human subjects, human data, or human anatomical materials?

The announcement points applicants to the program’s general application instructions, including Appendix 5, for additional rules and expectations related to human subjects, human data, or human anatomical materials.

Who manages this funding opportunity?

The TSCRP is managed by the U.S. Army Medical Research Acquisition Activity (USAMRAA) as part of the DoD’s Congressionally Directed Medical Research Programs (CDMRP) infrastructure for biomedical research funding.

What type of funding instrument is used?

This opportunity is offered as a cooperative agreement grant.

What is the funding category for this opportunity?

The opportunity is listed in the science and technology/research and development category.

How many awards were anticipated and what was the estimated total funding level?

The anticipated number of awards was three, with an estimated total funding level of $2.1 million.

Is cost sharing or matching required?

No. The notice states that cost sharing or matching was not required.

What was the CFDA number associated with this opportunity?

The CFDA listing associated with the opportunity is 12.420 (Military Medical Research and Development).

What were the key dates (posting, closing, and archive)?

The opportunity was posted on February 16, 2010. The application closing date was May 6, 2010. The archive date was June 5, 2010.

Who was eligible to apply?

Eligibility was listed as unrestricted, meaning it was open to any applicant entity type unless further limited by additional eligibility language in the full announcement.

What support was available for applicants during submission?

The announcement provided contact points for help accessing the announcement and for electronic submission assistance through CDMRP help desk channels, consistent with the DoD CDMRP submission infrastructure.

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