Opportunity Information: Apply for W81XWH 13 TSCRP IDA
Apply for W81XWH 13 TSCRP IDA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Tuberous Sclerosis Complex Idea Development Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on May 3, 2013 and posted on May 3, 2013.
- Applicants must submit their applications by Jul 11, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,200,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Tuberous Sclerosis Complex (TSC) Idea Development Award (FY13 TSCRP) is a research funding opportunity from the Department of the Army, administered through the Congressionally Directed Medical Research Programs (CDMRP), designed to push the TSC field forward through high-impact, innovative projects. Its overall mission is to support work that improves the lives of people with TSC by deepening understanding of the disease biology (pathogenesis) and the many ways it presents clinically (manifestations). The award is positioned for projects that take creative, well-supported ideas and move them into compelling new directions, especially where the research could open up new therapeutic, diagnostic, or mechanistic pathways.
The program highlights a set of priority Focus Areas that proposals are encouraged to address. These include studies on genetic, epigenetic, and non-genetic modifiers that may influence how TSC develops and varies between patients; development and use of preclinical models and therapeutic strategies such as cytotoxic agents and combination approaches; and the discovery or validation of biomarkers that could enable earlier detection, better prognosis, or prediction of treatment response, including serum markers, imaging-based measures, electrophysiology, prenatal testing, and pharmacogenetics. Additional emphasis is placed on adult manifestations of TSC, including adult care management and age-specific disease mechanisms, epidemiology, renal and reproductive issues, and lymphangioleiomyomatosis (LAM). The announcement also calls for work evaluating long-term benefits and effects of mTOR inhibitors or other agents, as well as novel strategies for diagnosis, treatment, and prevention that support early identification and early intervention. Mechanistic work is encouraged too, particularly cellular and molecular studies of TSC and LAM pathogenesis, along with research into the causes and treatment of epilepsy in TSC and TSC-associated neurocognitive disorders, including cognitive impairment as well as psychiatric, behavioral, and sleep-related challenges.
This award mechanism is explicitly oriented toward innovation but does not support clinical trials. Preclinical research is encouraged, meaning applicants can propose studies in cell systems, animal models, translational platforms, or other non-trial human-centered research approaches that do not constitute a clinical trial. At the same time, the program requires that proposals be grounded in relevant evidence: applicants must include preliminary or published data tied to TSC and to the proposed project, signaling that the award is meant for ideas that are new and bold but not purely speculative.
The opportunity is also structured to attract and grow the investigator pipeline in TSC. It encourages applications from new investigators in TSC, defined in part as those who have not received more than $300,000 in total direct costs for TSC research as a principal investigator on one or more federally funded, non-mentored, peer-reviewed awards. It also welcomes established independent investigators who have built careers in areas outside TSC and want to transition into TSC research, which is a common way programs like this bring fresh tools and perspectives into a disease area.
Administratively, this FY13 funding opportunity (W81XWH-13-TSCRP-IDA) was offered as a discretionary program using grant and cooperative agreement instruments under CFDA 12.420 (Military Medical Research and Development). Cost sharing or matching was not required, eligibility was listed as unrestricted (open to any entity type, subject to any additional eligibility notes in the full announcement), and the program anticipated making about four awards. The estimated total funding was $3.2 million. The opportunity was posted May 3, 2013, with an application deadline of July 11, 2013, and it was archived August 10, 2013. For support accessing the full announcement, the listed contact was the CDMRP Help Desk (301-682-5507, help@cdmrp.org).
Frequently Asked Questions (FAQs)
What is the DoD Tuberous Sclerosis Complex (TSC) Idea Development Award (FY13 TSCRP)?
The DoD Tuberous Sclerosis Complex (TSC) Idea Development Award (FY13 TSCRP) is a Department of the Army research funding opportunity administered through the Congressionally Directed Medical Research Programs (CDMRP). It is intended to push the TSC field forward through high-impact, innovative research projects.
What is the main goal or mission of this award?
The mission is to support research that improves the lives of people with TSC by advancing understanding of TSC disease biology (pathogenesis) and the many ways TSC presents clinically (manifestations). The award is positioned to move creative, well-supported ideas into compelling new directions that may open therapeutic, diagnostic, or mechanistic pathways.
What kinds of projects does this award aim to support?
The award emphasizes innovation and high impact. It supports projects that are grounded in relevant evidence and can meaningfully advance understanding of TSC and/or lead toward new approaches for diagnosis, treatment, prevention, or mechanistic insight.
Does the program provide a list of priority research focus areas?
Yes. The announcement highlights multiple priority Focus Areas that proposals are encouraged to address, spanning modifiers of disease, preclinical models and therapeutic strategies, biomarkers, adult manifestations, long-term effects of agents such as mTOR inhibitors, mechanistic studies, and neurologic and neurocognitive aspects of TSC.
What Focus Areas related to disease modifiers are encouraged?
The program encourages studies on genetic, epigenetic, and non-genetic modifiers that may influence how TSC develops and why disease presentation varies between patients.
What Focus Areas related to preclinical models and therapies are encouraged?
The opportunity encourages development and use of preclinical models and therapeutic strategies, including cytotoxic agents and combination approaches.
What biomarker-related research does the program encourage?
The program encourages discovery or validation of biomarkers that could support earlier detection, improved prognosis, or prediction of treatment response. Examples mentioned include serum markers, imaging-based measures, electrophysiology, prenatal testing, and pharmacogenetics.
Is research on adult manifestations of TSC specifically encouraged?
Yes. The announcement places additional emphasis on adult manifestations of TSC, including adult care management and age-specific disease mechanisms, epidemiology, renal and reproductive issues, and lymphangioleiomyomatosis (LAM).
Does the opportunity mention mTOR inhibitors?
Yes. The announcement calls for work evaluating long-term benefits and effects of mTOR inhibitors or other agents.
Does the program encourage early diagnosis and early intervention strategies?
Yes. The opportunity emphasizes novel strategies for diagnosis, treatment, and prevention that support early identification and early intervention.
What kind of mechanistic studies are encouraged?
Mechanistic work is encouraged, including cellular and molecular studies of TSC and LAM pathogenesis.
Are epilepsy and neurocognitive issues within scope?
Yes. The announcement encourages research into the causes and treatment of epilepsy in TSC and TSC-associated neurocognitive disorders, including cognitive impairment as well as psychiatric, behavioral, and sleep-related challenges.
Are clinical trials allowed under this award?
No. This award mechanism is explicitly oriented toward innovation but does not support clinical trials.
What types of research are encouraged instead of clinical trials?
Preclinical research is encouraged. The announcement indicates applicants may propose studies in cell systems, animal models, translational platforms, or other non-trial human-centered research approaches that do not constitute a clinical trial.
Is preliminary data required for an application?
Yes. Proposals must be grounded in relevant evidence. Applicants are required to include preliminary or published data tied to TSC and to the proposed project, indicating that projects should be innovative but not purely speculative.
Who is the program trying to attract as applicants?
The opportunity is structured to attract and grow the investigator pipeline in TSC. It encourages applications from new investigators in TSC and also welcomes established independent investigators who have built careers outside TSC and want to transition into TSC research.
How does the program describe a "new investigator in TSC"?
A new investigator in TSC is defined in part as someone who has not received more than $300,000 in total direct costs for TSC research as a principal investigator on one or more federally funded, non-mentored, peer-reviewed awards.
Can an established investigator from another field apply if they want to move into TSC research?
Yes. The program welcomes established independent investigators who have built careers in areas outside TSC and want to transition into TSC research.
Which government office administers this funding opportunity?
The award is from the Department of the Army and is administered through the Congressionally Directed Medical Research Programs (CDMRP).
What is the program identifier for this FY13 opportunity?
The opportunity is identified as W81XWH-13-TSCRP-IDA.
What funding instruments were used for this opportunity?
The FY13 opportunity was offered as a discretionary program using grant and cooperative agreement instruments.
What CFDA number is associated with this opportunity?
The CFDA number listed is 12.420 (Military Medical Research and Development).
Was cost sharing or matching required?
No. Cost sharing or matching was not required.
Who was eligible to apply?
Eligibility was listed as unrestricted (open to any entity type), subject to any additional eligibility notes in the full announcement.
How many awards were anticipated?
The program anticipated making about four awards.
What was the estimated total funding available?
The estimated total funding was $3.2 million.
When was the opportunity posted, and what was the application deadline?
The opportunity was posted on May 3, 2013, and the application deadline was July 11, 2013.
Is this opportunity still open?
No. The opportunity was archived on August 10, 2013.
Who should be contacted for help accessing the full announcement?
For support accessing the full announcement, the listed contact was the CDMRP Help Desk at 301-682-5507 or help@cdmrp.org.
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