DoW Lupus, Transformative Vision Development Award | Apply Online

Opportunity Summary:

The Department of the Army, through the U.S. Army Medical Research Acquisition Activity (USAMRAA), is offering the FY26 Lupus Research Program (LRP) Transformative Vision Development Award (TVDA) under Funding Opportunity Number HT942526LRPTVDA. This is a discretionary research grant in the Science and Technology/Research and Development category (CFDA 12.420). The opportunity is designed to help investigators take the early, practical steps needed to launch a future interventional lupus study by funding planning work and early pilot efforts that can produce the kind of preliminary evidence reviewers look for when deciding whether a larger clinical effort is ready.

The main purpose of this award is to support development activities and pilot studies that generate preliminary data and demonstrate feasibility for the aims of a later interventional study. In other words, the grant is meant to help teams test whether their proposed approach can realistically be carried out, whether key procedures and measurements work as intended, and whether early signals justify moving to a larger intervention-focused project. If the work is successful, the resulting study package can be positioned for submission to a future Lupus Research Program Transformative Vision Award (TVA) or a similar follow-on mechanism, with the related future opportunity referenced as HT942526LRPTVA.

Projects must align with at least one of the FY26 LRP Transformative Vision Development Award focus areas. While the specific focus areas are not listed in the provided text, applicants are expected to choose and clearly address one or more of those FY26 priorities in their proposal, since responsiveness to the focus areas is a core requirement for fit under this mechanism.

In terms of what kinds of studies are allowed, the TVDA supports early-stage clinical testing when appropriate, including phase 0 or phase 1 clinical trials. However, it explicitly does not allow phase 2 or phase 3 clinical trials, and it does not allow animal studies. That restriction signals that the program is aiming for groundwork that accelerates translation toward human interventions while keeping the scope at an early clinical readiness level rather than large efficacy trials or preclinical animal experimentation.

A few features stand out. Preliminary data are allowed but not required, which lowers the barrier for promising, well-justified concepts that still need initial feasibility proof. At the same time, the award still expects applicants to produce meaningful pilot results or feasibility evidence during the funding period, because the entire point is to de-risk a future interventional submission. Another distinctive requirement is that every application must include at least one lupus consumer advocate on the research team, emphasizing patient-centered relevance and ensuring that lived experience helps shape the research questions, design choices, and practical considerations that matter to the lupus community.

There are also limits on how investigators can participate across the broader FY26 LRP portfolio. An individual may only serve as Principal Investigator on one application per LRP award mechanism (Idea Award, Impact Award, TVDA, TVA). Across the FY26 LRP as a whole, that means a person could be PI on up to four applications total, but only one per mechanism. This is meant to spread leadership opportunities and reduce the likelihood of one PI submitting multiple applications in the same lane.

Eligibility is listed as unrestricted, indicating a broad range of applicant organizations or entities may apply as long as they meet standard federal grant requirements. The original application closing date is August 24, 2026. The opportunity anticipates making about two awards. The award ceiling is not specified in the provided source text, so applicants would need to consult the full announcement package for budget limits, allowable costs, and period of performance details.

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