Opportunity Information: Apply for PA 11 311

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Drug Abuse Prevention Intervention Research (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
  • This funding opportunity was created on Aug 11, 2014 and posted on Aug 16, 2011.
  • Applicants must submit their applications by Jan 7, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Special district governments Private institutions of higher education Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Independent school districts State governments For profit organizations other than small businesses County governments Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) City or township governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The Drug Abuse Prevention Intervention Research (R01) opportunity (Funding Opportunity Number PA 11 311) is a National Institutes of Health discretionary grant program designed to support full-scale research projects that strengthen the evidence base for preventing drug abuse and its related harms. It uses the NIH Research Project Grant (R01) mechanism, meaning applicants are expected to propose a well-developed, hypothesis-driven (or otherwise rigorously justified) program of research that can meaningfully advance prevention science, rather than a small pilot or planning effort. The overarching goal is to move the field toward population-level impact by identifying, refining, and improving strategies that prevent drug use initiation, escalation, and dependence, while also reducing downstream health and social consequences.

A central focus of the announcement is innovation and practical relevance in prevention. The FOA encourages projects that develop entirely new prevention approaches, as well as studies that test novel interventions or adapt existing interventions for new settings, populations, or delivery platforms. In practice, this can include designing new behavioral, social, structural, service-delivery, or technology-enabled prevention strategies, and then evaluating them with strong scientific methods to determine whether they work, for whom they work, and under what conditions they are most effective. Alongside the creation and testing of interventions, the FOA highlights the importance of understanding how prevention approaches are selected and used in real-world systems, including the steps involved in adoption, adaptation, implementation, long-term sustainability, and financing. That emphasis reflects a strong interest not only in whether an intervention can succeed in a study, but also in whether it can be maintained, paid for, and scaled within communities, health systems, schools, justice settings, or other service environments.

The opportunity also explicitly supports methodological advances that make prevention research more rigorous and informative. Applicants are encouraged to develop new or improved methodologies suitable for designing and analyzing prevention studies, which may involve better trial designs, improved measurement strategies, analytic methods for complex implementation processes, or approaches that handle multi-level and real-world data challenges. The intent is to expand the prevention research toolkit so that future studies can more accurately estimate effects, understand mechanisms of change, and address the realities of conducting research in community and service settings.

In terms of public health targets, the FOA frames drug abuse prevention broadly, including not only drug use and dependence, but also drug-related problems such as mental health impacts, interpersonal violence, criminal justice involvement, and productivity loss. It also specifically includes drug-related disorders and comorbidities, calling out co-occurring substance use and psychiatric disorders and infections associated with drug use, including HIV as well as hepatitis B and hepatitis C. A key theme is drug-related HIV prevention, indicating that proposals aligned with reducing HIV risk linked to substance use behaviors or contexts fit squarely within the program purpose.

Eligibility is expansive and includes a wide range of domestic and international organizations. Eligible applicants listed include state, county, city/township, and special district governments; public and private institutions of higher education; nonprofits with or without 501(c)(3) status (with the exception notes typical for institutions of higher education); small businesses and other for-profit organizations (other than small businesses); independent school districts; public housing authorities/Indian housing authorities; and tribal governments and tribal organizations. The FOA also notes additional eligible applicants such as faith-based or community-based organizations, Historically Black Colleges and Universities, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities, regional organizations, U.S. territories or possessions, and federal agencies. Non-U.S. entities (foreign institutions) are eligible to apply, and foreign components of U.S. organizations are allowed as defined in NIH policy, which signals openness to international prevention research and cross-national collaboration when scientifically justified.

Administratively, the program is cataloged under CFDA 93.279 (Drug Abuse and Addiction Research Programs) and does not require cost sharing or matching. The posting history in the provided record shows it was posted August 16, 2011, with closing dates listed for September 7, 2014 and January 7, 2015, and an archive date of February 6, 2015, indicating this specific listing is historical rather than currently open. The full announcement was hosted through the NIH Grants Guide (link provided in the source), and NIH’s Office of Extramural Research webmaster contact is included for access or technical issues.

Frequently Asked Questions (FAQs)

What is the Drug Abuse Prevention Intervention Research (R01) opportunity (PA 11 311)?

PA 11 311 is a National Institutes of Health (NIH) discretionary grant opportunity that supports full-scale research projects aimed at strengthening the evidence base for preventing drug abuse and related harms. It uses the NIH Research Project Grant (R01) mechanism.

What is the main goal of this funding opportunity?

The overarching goal is to move prevention science toward population-level impact by identifying, refining, and improving strategies that prevent drug use initiation, escalation, and dependence, while also reducing downstream health and social consequences.

What type of grant mechanism is used?

This opportunity uses the NIH Research Project Grant (R01) mechanism, which is intended for well-developed research projects rather than small pilot, feasibility, or planning efforts.

Are pilot studies or planning grants a good fit for this FOA?

Based on the description, the program is designed for full-scale R01 projects and emphasizes a well-developed, hypothesis-driven (or otherwise rigorously justified) research program. That framing suggests it is not intended for small pilot-only or planning-only projects.

What kinds of prevention research projects are encouraged?

The FOA encourages innovative and practically relevant prevention research, including development of entirely new prevention approaches, testing novel interventions, and adapting existing interventions for new settings, populations, or delivery platforms.

What types of interventions can be supported?

The opportunity can include behavioral, social, structural, service-delivery, or technology-enabled prevention strategies, as long as they are evaluated with strong scientific methods to determine whether they work, for whom they work, and under what conditions they are most effective.

Does the FOA support adapting existing interventions to new contexts?

Yes. The FOA explicitly encourages studies that adapt existing interventions for new settings, populations, or delivery platforms.

Does the FOA care about real-world implementation and sustainability?

Yes. A stated emphasis is understanding how prevention approaches are selected and used in real-world systems, including adoption, adaptation, implementation, long-term sustainability, and financing.

Can projects focus on how interventions are financed and maintained over time?

Yes. The FOA highlights interest in whether interventions can be maintained, paid for, and scaled within real-world environments such as communities, health systems, schools, justice settings, and other service settings.

Are methodological research projects allowed under this opportunity?

Yes. The FOA explicitly supports methodological advances that make prevention research more rigorous and informative, including new or improved methodologies for designing and analyzing prevention studies.

What kinds of methodological advances are mentioned?

Examples mentioned include improved trial designs, improved measurement strategies, analytic methods for complex implementation processes, and approaches that address multi-level and real-world data challenges.

What outcomes or public health problems fall under the FOA's definition of drug abuse prevention?

The FOA frames drug abuse prevention broadly, including drug use and dependence and drug-related problems such as mental health impacts, interpersonal violence, criminal justice involvement, and productivity loss.

Does this FOA include co-occurring disorders and infections related to drug use?

Yes. The FOA specifically references drug-related disorders and comorbidities, including co-occurring substance use and psychiatric disorders and infections associated with drug use, including HIV, hepatitis B, and hepatitis C.

Is drug-related HIV prevention within scope?

Yes. Drug-related HIV prevention is identified as a key theme, and proposals aligned with reducing HIV risk linked to substance use behaviors or contexts are described as fitting squarely within the program purpose.

Who is eligible to apply?

Eligibility is broad and includes many domestic and international organizations. Listed eligible applicants include various government entities, higher education institutions, nonprofits (with or without 501(c)(3) status), small businesses, other for-profit organizations (other than small businesses), independent school districts, public housing authorities/Indian housing authorities, and tribal governments and tribal organizations.

Are faith-based or community-based organizations eligible?

Yes. The FOA notes eligibility for faith-based or community-based organizations.

Are minority-serving institutions specifically mentioned as eligible?

Yes. The FOA lists Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities.

Are U.S. territories and possessions eligible?

Yes. The FOA notes U.S. territories or possessions among eligible applicants.

Can federal agencies apply?

Yes. Federal agencies are listed among eligible applicants.

Are non-U.S. (foreign) institutions eligible to apply?

Yes. Non-U.S. entities (foreign institutions) are explicitly eligible to apply.

Are foreign components of U.S. organizations allowed?

Yes. The FOA states that foreign components of U.S. organizations are allowed as defined in NIH policy.

Is cost sharing or matching required?

No. The record states the program does not require cost sharing or matching.

What is the CFDA number associated with this opportunity?

The program is cataloged under CFDA 93.279, Drug Abuse and Addiction Research Programs.

Is this funding opportunity currently open?

Based on the provided record, this specific listing appears to be historical. It shows a posting date of August 16, 2011, closing dates of September 7, 2014 and January 7, 2015, and an archive date of February 6, 2015.

Where was the full announcement hosted?

The full announcement was hosted through the NIH Grants Guide (a link was provided in the source record).

Who is the contact for access or technical issues mentioned in the record?

The record includes the NIH Office of Extramural Research webmaster contact for access or technical issues.

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