Opportunity Information: Apply for RFA GM 13 001
Apply for RFA GM 13 001
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Dynamics of Host Associated Microbial Communities (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on Sep 28, 2011 and posted on Sep 28, 2011.
- Applicants must submit their applications by Jan 13, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,500,000.00 to eligible and selected applicants.
- Eligible applicants include: For profit organizations other than small businesses Private institutions of higher education County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Independent school districts Special district governments Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Small businesses City or township governments Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH National Institute of General Medical Sciences (NIGMS) funding opportunity titled "Dynamics of Host Associated Microbial Communities (R01)" (Funding Opportunity Number: RFA-GM-13-001) was a discretionary grant program using the NIH R01 research project grant mechanism. It focused on supporting basic research that digs into how microbial communities that live in or on hosts (such as animals, humans, insects, or plants) behave as dynamic, interacting systems. The core aim was to fund genetic, physiological, and ecological studies that could uncover general, transferable principles about how symbiotic host-associated microbiomes are formed, maintained, change over time, and influence or respond to their hosts. Rather than emphasizing a single disease or clinical application, the FOA highlighted fundamental mechanisms and system-level dynamics, meaning projects were expected to go beyond descriptive surveys and instead explain how and why community structure and function shift under different conditions.
Scientifically, the announcement targeted research that treats host-microbe associations as integrated symbiotic systems with measurable rules and mechanisms. Applications were encouraged to investigate community dynamics using approaches such as genetics (for example, identifying microbial or host genes that shape colonization, persistence, competition, cooperation, or signaling), physiology (such as metabolic interactions, nutrient exchange, stress responses, and host-microbe communication pathways), and ecology (including succession, stability, resilience, niche partitioning, dispersal, and responses to environmental perturbations). In practice, that scope could include controlled experimental systems, natural host-associated communities, or model organisms, as long as the work aimed to reveal basic governing principles of how these communities assemble and function within a host context. The emphasis on "dynamics" signals interest in time-dependent behavior and system responses, such as how communities shift with diet, development, immune changes, antibiotics or other disturbances, or changes in host environment, and what mechanisms drive recovery, collapse, or long-term alternative stable states.
From an administrative and eligibility standpoint, the program was broadly open to many types of applicants. Eligible applicants included public and private institutions of higher education, nonprofit organizations (both with and without 501(c)(3) status), for-profit organizations (including small businesses and other for-profits), and multiple levels of government entities (state, county, city/township, special district, and independent school districts), as well as public housing authorities/Indian housing authorities. It also explicitly allowed applications from tribal governments and tribal organizations, regional organizations, and a range of mission-serving institutions such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities. A notable feature was that non-U.S. entities (foreign institutions) were eligible to apply, non-U.S. components of U.S. organizations were eligible, and foreign components were allowed under NIH policy, which signaled that the research problem was considered globally relevant and that strong international microbiome and symbiosis research programs could participate directly.
The FOA carried an estimated total funding level of $2,500,000 and did not require cost sharing or matching. It was posted on September 28, 2011, with an original and current closing date of January 13, 2012, and it was archived on February 13, 2012. The activity was listed under the health funding category with CFDA number 93.859 (Biomedical Research and Research Training). Applicants seeking the full, official details were directed to the NIH Grants Guide notice page (link provided in the opportunity record), and technical help for accessing or linking to the announcement was routed through the NIH Office of Extramural Research (OER) webmaster contact.
Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The funding opportunity is titled "Dynamics of Host Associated Microbial Communities (R01)" from the NIH National Institute of General Medical Sciences (NIGMS).
What is the funding opportunity number (FOA number)?
The Funding Opportunity Number is RFA-GM-13-001.
What kind of grant mechanism does this opportunity use?
This opportunity uses the NIH R01 research project grant mechanism.
What type of program is this?
It is described as a discretionary grant program.
What is the main scientific focus of the FOA?
The FOA focuses on basic research to understand how host-associated microbial communities (microbiomes living in or on hosts such as animals, humans, insects, or plants) behave as dynamic, interacting systems.
What is the core aim of the program?
The core aim is to support genetic, physiological, and ecological studies that identify general, transferable principles governing how symbiotic host-associated microbiomes form, are maintained, change over time, and influence or respond to their hosts.
Is the FOA focused on a specific disease or clinical application?
No. The FOA emphasizes fundamental mechanisms and system-level dynamics rather than targeting a single disease or a specific clinical application.
Does the FOA encourage descriptive microbiome surveys?
The FOA emphasizes projects that go beyond descriptive surveys. Applicants were expected to explain how and why community structure and function shift under different conditions, focusing on mechanisms and governing principles.
What does the FOA mean by focusing on "dynamics"?
The emphasis on "dynamics" signals interest in time-dependent behavior and system responses, including how microbial communities shift and respond to changing conditions and what mechanisms drive recovery, collapse, or long-term alternative stable states.
What kinds of research approaches are encouraged?
Applications were encouraged to investigate host-microbe community dynamics using approaches such as genetics, physiology, and ecology, with the goal of treating host-microbe associations as integrated symbiotic systems with measurable rules and mechanisms.
What genetic research topics are within scope?
Examples given include identifying microbial or host genes that shape colonization, persistence, competition, cooperation, or signaling within host-associated communities.
What physiological research topics are within scope?
Examples include metabolic interactions, nutrient exchange, stress responses, and host-microbe communication pathways.
What ecological research topics are within scope?
Examples include succession, stability, resilience, niche partitioning, dispersal, and responses to environmental perturbations.
What types of study systems could be proposed?
The scope could include controlled experimental systems, natural host-associated communities, or model organisms, as long as the work aims to reveal basic governing principles of how communities assemble and function within a host context.
What kinds of perturbations or changing conditions are relevant to this FOA?
The FOA highlights community shifts related to factors such as diet, development, immune changes, antibiotics or other disturbances, or changes in the host environment, and asks for mechanistic explanations of the resulting system behavior.
Who is the sponsoring NIH Institute?
The sponsoring Institute is the NIH National Institute of General Medical Sciences (NIGMS).
What is the estimated total funding level for this FOA?
The estimated total funding level is $2,500,000.
Is cost sharing or matching required?
No. The FOA states that it did not require cost sharing or matching.
When was the opportunity posted?
The FOA was posted on September 28, 2011.
What was the application closing date?
The original and current closing date listed is January 13, 2012.
Is this funding opportunity still open?
No. It was archived on February 13, 2012.
What is the funding category and CFDA number?
The activity was listed under the health funding category with CFDA number 93.859 (Biomedical Research and Research Training).
What types of U.S. organizations were eligible to apply?
Eligible applicants included public and private institutions of higher education, nonprofit organizations (with and without 501(c)(3) status), for-profit organizations (including small businesses and other for-profits), and multiple levels of government entities (state, county, city/township, special district, and independent school districts), as well as public housing authorities/Indian housing authorities.
Are tribal governments and tribal organizations eligible?
Yes. The FOA explicitly allows applications from tribal governments and tribal organizations.
Are mission-serving institutions specifically included as eligible applicants?
Yes. The FOA explicitly includes a range of mission-serving institutions such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities.
Are non-U.S. (foreign) institutions eligible to apply?
Yes. Non-U.S. entities (foreign institutions) were eligible to apply.
Can a U.S. organization include a non-U.S. component?
Yes. Non-U.S. components of U.S. organizations were eligible.
Are foreign components allowed on applications?
Yes. Foreign components were allowed under NIH policy, as stated in the opportunity summary.
Where should applicants look for the official FOA details?
Applicants were directed to the NIH Grants Guide notice page linked in the opportunity record for the full, official details.
Where is technical help available for accessing or linking to the announcement?
Technical help for accessing or linking to the announcement was routed through the NIH Office of Extramural Research (OER) webmaster contact.
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