Opportunity Information: Apply for RFA GM 12 001
Apply for RFA GM 12 001
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Dynamics of Host Associated Microbial Communities (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on Sep 9, 2010 and posted on Sep 9, 2010.
- Applicants must submit their applications by Jan 14, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- Eligible applicants include: Small businesses Private institutions of higher education Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Non domestic (non U.S.) Entities (Foreign Organizations) Tribally Controlled Colleges and Universities (TCCUs) .
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Opportunity Summary:
The Dynamics of Host Associated Microbial Communities (R01) opportunity (Funding Opportunity Number RFA-GM-12-001) is a National Institutes of Health grant announcement issued by the National Institute of General Medical Sciences (NIGMS). Its core goal is to support basic research that explains how microbial communities behave when they live in close association with a host organism. Rather than focusing on a single microbe in isolation, the FOA emphasizes symbiotic systems and the underlying rules that shape how multi-species microbial communities form, persist, change over time, and interact with their host. The scientific scope centers on studies that use genetics, physiology, and ecology to uncover fundamental principles and mechanisms that control community dynamics in host-associated environments.
Projects proposed under this FOA are expected to be hypothesis-driven and mechanistic, aimed at explaining why microbial communities shift or stabilize, how microbes influence each other in the context of a host, and how the host environment helps structure these communities. The announcement highlights systems-level dynamics, meaning applicants are encouraged to think in terms of interactions, feedback loops, and ecological processes (for example, colonization, competition, cooperation, succession, and resilience), while also linking those processes to genetic and physiological mechanisms. The overall emphasis is on foundational knowledge that can generalize across symbiotic host-microbe systems, fitting NIGMS's mission of supporting fundamental biomedical science rather than disease-specific applications.
The mechanism of support is the NIH Research Project Grant (R01), which is the standard NIH program for funding discrete, investigator-initiated research projects. The FOA is categorized as a discretionary grant opportunity within the health funding activity area (CFDA 93.859, Biomedical Research and Research Training). No cost sharing or matching is required, which means applicants are not expected to provide institutional or third-party funds as a condition of receiving an award.
In terms of funding scale, NIGMS anticipated a total investment of about $2.5 million in total costs for this FOA, with an expected 5 to 6 awards. The listed award ceiling is $250,000, indicating an upper limit on the amount available per award under the terms summarized in the source data (final award levels would still depend on the approved budget, project scope, and NIH policies). As with most NIH solicitations, awards are contingent on the availability of appropriated funds and the submission of a sufficient number of highly competitive applications.
Eligibility is broad and includes many common NIH applicant types across academia, nonprofit research, and certain for-profit entities. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, small businesses, for-profit organizations other than small businesses, and nonprofit organizations (both with and without 501(c)(3) status). The FOA also explicitly allows a range of other eligible institutions and organizations, including federally eligible agencies and several categories of minority-serving and mission-specific institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions. Importantly, non-U.S. entities (foreign organizations) are also listed among eligible applicants, widening the pool to include qualified international research organizations.
Key dates show that the opportunity was posted and created on September 9, 2010, with an original and current closing date of January 14, 2011, and an archive date of February 14, 2011. The full announcement was made available through the NIH Grants Guide, and the contact provided in the source data points to the NIH Office of Extramural Research (OER) webmaster for technical issues accessing the announcement online.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled The Dynamics of Host Associated Microbial Communities (R01).
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-GM-12-001.
Which federal agency and NIH institute issued this FOA?
This is a National Institutes of Health (NIH) grant announcement issued by the National Institute of General Medical Sciences (NIGMS).
What is the overall purpose of this FOA?
The core goal is to support basic research that explains how microbial communities behave in close association with a host organism, focusing on symbiotic systems and the rules that govern how multi-species communities form, persist, change over time, and interact with their host.
Does this FOA focus on single microbes or microbial communities?
The FOA emphasizes multi-species microbial communities in symbiotic (host-associated) systems, rather than studying a single microbe in isolation.
What kinds of scientific approaches does the FOA emphasize?
The scope centers on studies using genetics, physiology, and ecology to uncover fundamental principles and mechanisms that control community dynamics in host-associated environments.
What types of research projects are expected to be competitive under this FOA?
Projects are expected to be hypothesis-driven and mechanistic, aimed at explaining why host-associated microbial communities shift or stabilize, how microbes influence one another in the context of a host, and how the host environment structures these communities.
What does the FOA mean by "systems-level dynamics"?
The FOA highlights systems-level dynamics by encouraging applicants to think in terms of interactions, feedback loops, and ecological processes (for example, colonization, competition, cooperation, succession, and resilience) and to link these processes to underlying genetic and physiological mechanisms.
Is this FOA intended for disease-specific research?
The emphasis is on foundational knowledge that can generalize across host-microbe symbiotic systems, aligning with NIGMS's mission of supporting fundamental biomedical science rather than disease-specific applications.
What is the grant mechanism for this opportunity?
The mechanism of support is the NIH Research Project Grant (R01).
What does an R01 support in general terms (as described here)?
In this FOA, the R01 is described as the standard NIH program for funding discrete, investigator-initiated research projects.
What is the funding activity area and CFDA number associated with this opportunity?
The FOA is categorized within the health funding activity area, under CFDA 93.859 (Biomedical Research and Research Training).
Is cost sharing or matching required?
No. The FOA specifies that no cost sharing or matching is required, meaning applicants are not expected to provide institutional or third-party funds as a condition of receiving an award.
How much total funding did NIGMS anticipate for this FOA?
NIGMS anticipated a total investment of about $2.5 million in total costs for this FOA.
How many awards were expected?
The FOA expected approximately 5 to 6 awards.
What is the listed award ceiling for this opportunity?
The listed award ceiling is $250,000 (as summarized in the provided source data). Final award levels would still depend on the approved budget, project scope, and NIH policies.
Are awards guaranteed if an application is submitted?
No. As with most NIH solicitations, awards are contingent on the availability of appropriated funds and the receipt of a sufficient number of highly competitive applications.
Who is eligible to apply?
Eligibility is broad and includes many common NIH applicant types across academia, nonprofit research, and certain for-profit entities.
Are universities eligible to apply?
Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are nonprofit organizations eligible to apply?
Yes. The FOA includes nonprofit organizations with 501(c)(3) status and nonprofit organizations without 501(c)(3) status among eligible applicants.
Are for-profit organizations eligible to apply?
Yes. The FOA lists small businesses and for-profit organizations other than small businesses as eligible applicants.
Are minority-serving and mission-specific institutions eligible?
Yes. The FOA explicitly allows several categories of minority-serving and mission-specific institutions, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. The FOA lists non-U.S. entities (foreign organizations) among eligible applicants.
When was this opportunity posted and created?
The opportunity was posted and created on September 9, 2010.
What was the closing date for applications?
The original and current closing date listed is January 14, 2011.
When was the opportunity archived?
The archive date listed is February 14, 2011.
Where was the full announcement made available?
The full announcement was made available through the NIH Grants Guide.
Who is the contact for technical issues accessing the announcement online?
The contact provided in the source data points to the NIH Office of Extramural Research (OER) webmaster for technical issues related to accessing the announcement online.
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