Opportunity Information: Apply for RFA GM 14 001
Apply for RFA GM 14 001
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Dynamics of Host Associated Microbial Communities (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on Oct 17, 2012 and posted on Oct 17, 2012.
- Applicants must submit their applications by Jan 15, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Special district governments City or township governments Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments State governments Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH National Institute of General Medical Sciences (NIGMS) funding opportunity titled "Dynamics of Host Associated Microbial Communities (R01)" (Funding Opportunity Number RFA-GM-14-001) supported research aimed at understanding how microbial communities that live in or on hosts behave and change over time. The core focus was basic research, not product development or clinical intervention work, with an emphasis on uncovering fundamental principles that govern symbiotic systems. In practical terms, the FOA sought projects that could explain, at a mechanistic level, how host-associated microbiomes are established, maintained, and altered, and how the interactions among microbes and between microbes and their hosts drive community structure and function.
NIGMS specifically encouraged applications using genetic, physiological, and ecological approaches to study these systems as dynamic, interacting communities rather than as isolated organisms. That framing points to studies that probe cause-and-effect in community behavior, such as how gene functions influence microbial cooperation or competition, how environmental or host-derived constraints shape microbial physiology, and how ecological processes like succession, resilience, stability, and perturbation responses play out within host-associated settings. The term "symbiotic systems dynamics" signals interest in the full spectrum of host-microbe relationships (including mutualism, commensalism, and antagonism) and in how these relationships shift as conditions change.
The award mechanism was the NIH R01 research project grant, and the opportunity was categorized as discretionary funding in the health research area (CFDA 93.859, Biomedical Research and Research Training). The FOA indicated an estimated total funding amount of about $3,000,000 and listed an award ceiling of $250,000. It also stated there was no cost sharing or matching requirement, which generally means applicants were not expected to contribute non-federal funds as a condition of receiving an award.
Eligibility was broad and included a wide range of domestic and non-domestic organizations. Eligible applicants encompassed public and private institutions of higher education, nonprofits (both 501(c)(3) and non-501(c)(3)), small businesses, for-profit organizations other than small businesses, and multiple levels of government (state, county, city/township, special district). Tribal governments and tribal organizations were included, as were independent school districts and public housing authorities/Indian housing authorities. The FOA also explicitly listed additional eligible groups such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribal Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based and community-based organizations, U.S. territories or possessions, and eligible federal agencies. Importantly, foreign organizations and foreign institutions were eligible to apply, and foreign components of U.S. organizations were allowed, consistent with NIH policy on foreign components.
In terms of timing and status, the opportunity was posted and created on October 17, 2012, with an original and current closing date of January 15, 2013, and it was archived on February 15, 2013. The full announcement was made available through the NIH grants website. For technical issues accessing or linking to the announcement, the contact provided was the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The funding opportunity is titled "Dynamics of Host Associated Microbial Communities (R01)" and is associated with the NIH National Institute of General Medical Sciences (NIGMS).
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-GM-14-001.
Which NIH institute is sponsoring this opportunity?
This opportunity is sponsored by the NIH National Institute of General Medical Sciences (NIGMS).
What mechanism of support does this FOA use?
The award mechanism is the NIH R01 research project grant.
What is the main scientific focus of the FOA?
The FOA supports research aimed at understanding how microbial communities that live in or on hosts behave and change over time, with a focus on community dynamics in host-associated settings.
Is this FOA focused on basic research or product development?
The core focus is basic research, not product development or clinical intervention work. The emphasis is on uncovering fundamental principles governing symbiotic systems.
What kinds of questions or outcomes were projects expected to address?
Projects were expected to explain, at a mechanistic level, how host-associated microbiomes are established, maintained, and altered, and how interactions among microbes and between microbes and hosts drive community structure and function.
What approaches did NIGMS encourage applicants to use?
NIGMS encouraged applications using genetic, physiological, and ecological approaches, treating microbiomes as dynamic, interacting communities rather than as isolated organisms.
What does "symbiotic systems dynamics" mean in the context of this FOA?
It signals interest in the full spectrum of host-microbe relationships (including mutualism, commensalism, and antagonism) and how these relationships shift as conditions change.
What types of community-level processes were highlighted as relevant?
The FOA pointed to ecological processes such as succession, resilience, stability, and responses to perturbations, as they occur within host-associated microbial communities.
Does the FOA emphasize studying microbes as isolated organisms?
No. The FOA emphasized studying these systems as dynamic, interacting communities, including microbe-microbe interactions and microbe-host interactions.
What is the funding category and general area of support?
The opportunity was categorized as discretionary funding in the health research area.
What CFDA number is associated with this opportunity?
The CFDA number listed is 93.859 (Biomedical Research and Research Training).
What was the estimated total funding amount?
The FOA indicated an estimated total funding amount of about $3,000,000.
What was the listed award ceiling?
The FOA listed an award ceiling of $250,000.
Was cost sharing or matching required?
No. The FOA stated there was no cost sharing or matching requirement.
Who was eligible to apply?
Eligibility was broad and included domestic and non-domestic organizations, including higher education institutions, nonprofits, small businesses, for-profit organizations (other than small businesses), and multiple levels of government.
Are U.S. state and local government entities eligible?
Yes. Eligible government applicants included state, county, city/township, and special district governments.
Are tribal governments and tribal organizations eligible?
Yes. Tribal governments and tribal organizations were included as eligible applicants.
Are independent school districts eligible?
Yes. Independent school districts were listed as eligible applicants.
Are public housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities were listed as eligible applicants.
Are higher education institutions eligible?
Yes. Public and private institutions of higher education were eligible to apply.
Are nonprofits eligible, and does 501(c)(3) status matter?
Yes. The FOA included nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status.
Are small businesses eligible?
Yes. Small businesses were listed among eligible applicants.
Are for-profit organizations eligible?
Yes. The FOA included for-profit organizations other than small businesses.
Are minority-serving institutions specifically included?
Yes. The FOA explicitly listed groups such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribal Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions.
Are faith-based and community-based organizations eligible?
Yes. Faith-based and community-based organizations were explicitly included.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions were explicitly listed as eligible applicants.
Are federal agencies eligible to apply?
Yes. The FOA noted that eligible federal agencies could apply.
Are foreign organizations eligible?
Yes. Foreign organizations and foreign institutions were eligible to apply.
Are foreign components of U.S. organizations allowed?
Yes. Foreign components of U.S. organizations were allowed, consistent with NIH policy on foreign components.
When was the FOA posted and created?
The FOA was posted and created on October 17, 2012.
What was the application closing date?
The original and current closing date listed was January 15, 2013.
Is the opportunity still open?
No. The FOA was archived on February 15, 2013.
Where was the full announcement made available?
The full announcement was made available through the NIH grants website.
Who should be contacted for technical problems accessing or linking to the announcement?
For technical issues accessing or linking to the announcement, the FOA provided the NIH Office of Extramural Research (OER) webmaster contact: FBOWebmaster@OD.NIH.GOV.
Does the FOA indicate any expectation of clinical intervention research?
The FOA emphasizes basic research rather than clinical intervention work.
Does the FOA indicate any expectation of mechanistic (cause-and-effect) investigation?
Yes. The FOA emphasized mechanistic explanations for how microbiomes are established, maintained, and altered, and how interactions drive structure and function.
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