Opportunity Information: Apply for PAS 10 274
Apply for PAS 10 274
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Early Career Award in Chemistry of Drug Abuse and Addiction (ECHEM) NIDA (R21/R33)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Aug 26, 2010 and posted on Aug 26, 2010.
- Applicants must submit their applications by Sep 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- Eligible applicants include: Independent school districts Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Special district governments City or township governments For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Native American tribal governments (Federally recognized) Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Early Career Award in Chemistry of Drug Abuse and Addiction (ECHEM) is a National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH) funding opportunity designed to bring new investigators into NIH-supported research by backing early-stage, chemistry-focused projects that directly relate to drug abuse and addiction. The central goal is to stimulate basic chemistry research with clear relevance to NIDA's mission, meaning projects should connect chemical principles, methods, or tool-building to understanding, detecting, characterizing, or ultimately addressing substances of abuse and the biology or behaviors tied to addiction. A key emphasis of the announcement is investigator status: it specifically encourages applications from newly independent researchers and investigators who have not previously held NIH funding, with the intent of helping them establish a foothold in NIH-funded research through a structured, milestone-driven award.
This opportunity uses the Exploratory/Developmental Phased Innovation grant mechanism (R21/R33). Instead of submitting two separate applications, applicants submit one integrated application that is explicitly organized into two sequential phases. The first phase is the R21 portion, which supports early, exploratory, and developmental work. That initial period is typically where applicants would de-risk the concept, generate proof-of-principle data, validate an approach, and establish feasibility. The second phase is the R33 portion, which supports the next step of the same project once the R21 milestones are met, allowing the research to expand into more mature development, scale-up, optimization, broader testing, or more definitive studies consistent with the proposed innovation path. Importantly, the announcement makes clear that applications proposing only an R21 or only an R33 will not be accepted; the program expects a true phased plan with an R21 stage that logically enables a follow-on R33 stage.
NIDA indicated that it planned to commit about $1.5 million in fiscal year 2011 to support an estimated 6 to 8 awards, though the final number and sizes of awards depend on scientific merit, programmatic priorities, and available funds. Because projects can vary widely in complexity and resource needs, the agency notes that both the size and duration of each award may differ across funded projects. The listing includes an award ceiling of $250,000, which signals an upper bound as presented in the source record, even while the overall budget strategy is framed around multiple awards within the set-aside total.
The program is a discretionary grant (not a contract) and falls under the broad activity area of education and health, tied to CFDA 93.279 (Drug Abuse and Addiction Research Programs). No cost sharing or matching is required, which means applicants generally are not expected to commit non-federal funds as a condition of the award. The funding opportunity number is PAS-10-274, it was posted on August 26, 2010, and it had an original and final closing date of September 7, 2013, with the archive date listed as October 8, 2013.
Eligibility is broad and includes many organization types that commonly apply to NIH opportunities. Eligible applicants include public and private institutions of higher education, nonprofits with and without 501(c)(3) status (other than institutions of higher education), for-profit organizations other than small businesses, small businesses, state and local governments (including county and city/township governments), independent school districts, special district governments, public housing authorities and Indian housing authorities, and tribal entities including federally recognized tribal governments as well as other tribal organizations. The announcement also specifies additional eligible categories such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, U.S. territories or possessions, regional organizations, eligible federal government agencies, and non-U.S. (foreign) entities. In practice, this broad eligibility widens participation and helps ensure that strong chemistry-focused addiction research ideas can come from a wide range of institutional settings.
For applicants trying to interpret what NIDA is looking for, the most important takeaways are the early-career focus and the chemistry-centered framing, paired with a structured plan that starts with feasibility and milestones (R21) and transitions into a more advanced development stage (R33). The agency states that awards will be made based on scientific and technical merit as well as NIDA program priorities, so proposals should be both scientifically compelling and clearly aligned with drug abuse and addiction relevance. The official NIH Grants Guide announcement is associated with PAS-10-274, and the record provides NIH Office of Extramural Research (OER) webmaster contact emails for technical access or linking issues.
Frequently Asked Questions (FAQs)
What is the Early Career Award in Chemistry of Drug Abuse and Addiction (ECHEM)?
ECHEM is a National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH) funding opportunity intended to bring new investigators into NIH-supported research by supporting early-stage, chemistry-focused projects that directly relate to drug abuse and addiction.
What is the main goal of this funding opportunity?
The central goal is to stimulate basic chemistry research that has clear relevance to NIDA's mission. Projects should connect chemical principles, methods, or tool-building to understanding, detecting, characterizing, or ultimately addressing substances of abuse and the biology or behaviors tied to addiction.
Who is this opportunity designed to support (investigator focus)?
The announcement specifically encourages applications from newly independent researchers and investigators who have not previously held NIH funding. The intent is to help early-stage investigators establish a foothold in NIH-funded research through a structured, milestone-driven award.
What grant mechanism does ECHEM use?
This opportunity uses the Exploratory/Developmental Phased Innovation grant mechanism (R21/R33). Applicants submit one integrated application that is organized into two sequential phases rather than submitting two separate applications.
How does the phased R21/R33 structure work?
The project is proposed as two linked stages. The first stage (R21) supports early, exploratory, and developmental work to de-risk the concept and establish feasibility. The second stage (R33) supports the next step of the same project once the R21 milestones are met, enabling more mature development consistent with the proposed innovation path.
What types of activities fit in the R21 phase?
Based on the description, the R21 portion is typically where applicants generate proof-of-principle data, validate an approach, establish feasibility, and otherwise reduce risk so that the project is positioned for the follow-on development phase.
What types of activities fit in the R33 phase?
The R33 portion supports continued work after successful completion of the R21 milestones. This can include expanded development, scale-up, optimization, broader testing, or more definitive studies that match the proposed innovation trajectory.
Can an applicant submit only an R21 or only an R33 application?
No. The announcement states that applications proposing only an R21 or only an R33 will not be accepted. The program expects an integrated, true phased plan in which the R21 logically enables a follow-on R33 stage.
How important are milestones in this opportunity?
Milestones are a key element. The award is described as structured and milestone-driven, with the expectation that R21 milestones are met in order to transition into the R33 phase.
How much funding did NIDA plan to commit and how many awards were expected?
NIDA indicated it planned to commit about $1.5 million in fiscal year 2011 to support an estimated 6 to 8 awards. The final number and size of awards depend on scientific merit, programmatic priorities, and available funds.
Is there an award ceiling listed for this opportunity?
Yes. The record includes an award ceiling of $250,000, presented as an upper bound in the source listing, while also noting that award size and duration may vary across projects.
Will the size and duration of each award be the same for all projects?
No. The agency notes that projects can vary widely in complexity and resource needs, and that both the size and duration of each award may differ across funded projects.
Is this funding a grant or a contract?
This is a discretionary grant, not a contract.
What is the activity area and CFDA number associated with this opportunity?
The program is listed under the broad activity area of education and health and is tied to CFDA 93.279 (Drug Abuse and Addiction Research Programs).
Is cost sharing or matching required?
No. The opportunity specifies that no cost sharing or matching is required, meaning applicants generally are not expected to commit non-federal funds as a condition of the award.
What is the funding opportunity number for ECHEM?
The funding opportunity number is PAS-10-274.
When was this opportunity posted and when did it close?
It was posted on August 26, 2010. The original and final closing date was September 7, 2013. The archive date is listed as October 8, 2013.
What types of organizations are eligible to apply?
Eligibility is broad. Eligible applicants include public and private institutions of higher education; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; state and local governments (including county and city/township governments); independent school districts; special district governments; public housing authorities and Indian housing authorities; and tribal entities including federally recognized tribal governments as well as other tribal organizations.
Are minority-serving institutions and community-based organizations eligible?
Yes. The announcement lists Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and faith-based or community-based organizations among eligible categories.
Are U.S. territories, regional organizations, and federal agencies eligible?
Yes. The eligible categories include U.S. territories or possessions, regional organizations, and eligible federal government agencies.
Are non-U.S. (foreign) entities eligible to apply?
Yes. The announcement includes non-U.S. (foreign) entities among eligible applicants.
What does NIDA emphasize when it comes to project fit?
The key emphasis is on early-career investigators and a chemistry-centered project framing with direct relevance to drug abuse and addiction. Proposals should connect chemical principles, methods, or tool-building to substances of abuse and to addiction-related biology or behaviors, and they should present a structured plan that moves from feasibility (R21) to more advanced development (R33).
How will awards be decided?
Awards will be made based on scientific and technical merit as well as NIDA program priorities, so proposals should be scientifically compelling and clearly aligned with NIDA's mission and interests.
Where is the official announcement associated with this opportunity found?
The opportunity is associated with an NIH Grants Guide announcement linked to PAS-10-274.
Who is listed as a contact for technical access or linking issues?
The record references NIH Office of Extramural Research (OER) webmaster contact emails for technical access or linking issues.
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