Opportunity Information: Apply for EPA G2011 STAR E2
Apply for EPA G2011 STAR E2
- The Environmental Protection Agency in the environment sector is offering a public funding opportunity titled "Early Career Projects Developing High Throughput Assays for Predictive Modeling of Reproductive and Developmental Toxicity Modulated through the Endocrine System or Pertinent Pathways in Humans and Species Relevant to Ecological Risk Assessment" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 66.509 Science To Achieve Results (STAR) Research Program.
- This funding opportunity was created on Jan 28, 2011 and posted on Jan 28, 2011.
- Applicants must submit their applications by May 5, 2011 Please see Section IV of the announcement for additional information on due dates and submission methods.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $10,800,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $1,200,000.00 in funding.
- The number of recipients for this funding is limited to 9 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
- Please see Section III of the announcement for eligibility information.
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Opportunity Summary:
This EPA Science to Achieve Results (STAR) funding opportunity (EPA G2011 STAR E2) supports research aimed at building and improving high throughput assay systems that can be used to test chemicals, or mixtures of chemicals, in ways that help explain and predict reproductive and developmental toxicity. The main scientific goal is to strengthen the ability to connect exposure to specific biological changes and then link those changes causally to adverse, real-world (apical) outcomes tied to development and reproduction. While the endocrine system is a central focus, the call is not limited to endocrine disruption; it also welcomes approaches that address other relevant biological pathways that can drive reproductive or developmental harm.
The work EPA is looking for is practical and predictive: assay platforms should generate data that can feed into models used for risk assessment, including predictive modeling approaches that help translate mechanistic or pathway-level signals into outcomes that matter for decision-making. In other words, the agency is encouraging projects that do more than just detect a biological interaction. They want assays that can help explain how and why an exposure leads to adverse endpoints, and that can ultimately improve the speed, scale, and confidence of toxicity testing compared with slower, more resource-intensive traditional testing.
A key feature of the solicitation is that assay systems should be relevant to humans and/or to species that matter for ecological risk assessment. That means proposals can be oriented toward human health, wildlife and ecological receptors, or both, as long as the selected systems are defensible as being informative for regulatory or environmental decision contexts. The emphasis on species relevant to ecological risk assessment signals interest in methods that can inform environmental protection decisions beyond human-centered toxicology, potentially including assays tailored to organisms or biological processes that serve as indicators for ecosystem impacts.
The announcement includes both regular awards and a specific avenue for early career projects. Early career eligibility requirements are laid out in Section III of the Request for Applications, and applicants who qualify are given an opportunity to compete within that track. The intent is to help newer investigators establish themselves while contributing to EPA priorities in next-generation toxicity testing and predictive toxicology.
Administratively, this is a discretionary funding opportunity under the EPA STAR Research Program (CFDA 66.509). Awards are offered as grants and/or cooperative agreements, with an estimated total funding level of $10,800,000 and an expected nine awards. The maximum award amount (ceiling) is listed as $1,200,000, and there is no cost-sharing or matching requirement. The opportunity was posted January 28, 2011, with an application closing date of May 5, 2011, and it was archived June 4, 2011. Submission logistics and any date nuances are referenced in Section IV of the full announcement.
For applicants needing support, the announcement provides contacts for eligibility questions (James Gentry, 703-347-8093), electronic submission issues (Ron Josephson, 703-308-0442), and technical questions about the research topic (Pasky Pascual, 703-347-8056). Overall, the opportunity is designed to push forward modern, high throughput methods that can better predict developmental and reproductive hazards from chemical exposures, particularly where endocrine or related pathway perturbations play a key role, while also building capacity among early career researchers.
Frequently Asked Questions (FAQs)
What is this EPA funding opportunity?
This is an EPA Science to Achieve Results (STAR) funding opportunity (EPA G2011 STAR E2) that supports research to build and improve high throughput assay systems for testing chemicals, or mixtures of chemicals, to better explain and predict reproductive and developmental toxicity.
What is the main scientific goal of the program?
The main goal is to strengthen the ability to connect exposure to specific biological changes and then link those changes causally to adverse, real-world (apical) outcomes related to development and reproduction.
What types of research projects is EPA looking for?
EPA is looking for practical, predictive assay platform research. The agency is encouraging projects that go beyond detecting a biological interaction and instead help explain how and why an exposure leads to adverse developmental or reproductive endpoints, improving the speed, scale, and confidence of toxicity testing compared with traditional approaches.
Are high throughput assays required?
The focus of the opportunity is on building and improving high throughput assay systems specifically designed to test chemicals or chemical mixtures in ways that help explain and predict reproductive and developmental toxicity.
Is the endocrine system the only focus area?
No. While the endocrine system is a central focus, the solicitation is not limited to endocrine disruption. It also welcomes approaches that address other relevant biological pathways that can drive reproductive or developmental harm.
What does EPA mean by linking mechanistic signals to "apical outcomes"?
Based on the announcement description, the intent is to connect pathway-level or mechanistic biological changes observed in assays to adverse outcomes that matter in real-world contexts for development and reproduction (that is, outcomes relevant for decision-making and risk assessment).
How should the assay data be used for risk assessment?
The solicitation emphasizes assay platforms that generate data suitable for models used in risk assessment, including predictive modeling approaches that translate mechanistic or pathway-level signals into outcomes that matter for decisions.
Does the opportunity support predictive modeling?
Yes. The announcement explicitly encourages predictive modeling approaches that can help translate assay outputs (mechanistic or pathway-level signals) into outcomes relevant for risk assessment and decision-making.
Are chemical mixtures within scope, or only single chemicals?
Both are within scope. The opportunity supports assay systems that can test chemicals or mixtures of chemicals.
Do proposed assay systems need to be relevant to humans?
Assay systems should be relevant to humans and/or to species that matter for ecological risk assessment. Projects can be oriented toward human health, ecological receptors, or both, as long as the systems are defensible for regulatory or environmental decision contexts.
Can projects focus on wildlife or ecological receptors instead of humans?
Yes. The solicitation highlights interest in species relevant to ecological risk assessment, signaling that assays tailored to organisms or biological processes important for ecosystem impact assessment may be responsive.
Is it acceptable to propose work that addresses both human health and ecological risk assessment?
Yes. The description indicates proposals may target human health, ecological receptors, or both, provided the selected systems are defensible for decision-making contexts.
What kinds of outcomes does EPA want these assays to improve?
The stated intent is to improve toxicity testing by making it faster, more scalable, and more confident than slower, more resource-intensive traditional testing, while also improving the ability to predict developmental and reproductive hazards from exposures.
What program is this opportunity offered under?
This is a discretionary funding opportunity under the EPA STAR Research Program, listed with CFDA 66.509.
What award mechanisms are available?
Awards are offered as grants and/or cooperative agreements.
How much total funding is expected to be available?
The estimated total funding level is $10,800,000.
How many awards does EPA expect to make?
The opportunity states an expected nine awards.
What is the maximum award amount (ceiling)?
The maximum award amount is listed as $1,200,000.
Is cost sharing or matching required?
No. The opportunity states there is no cost-sharing or matching requirement.
Is there an early career option or set-aside?
Yes. The announcement includes both regular awards and a specific avenue for early career projects. Early career eligibility requirements are described as being in Section III of the Request for Applications.
Who should apply under the early career track?
Applicants who meet the early career eligibility requirements in Section III of the Request for Applications can compete within that track. The intent is to help newer investigators establish themselves while contributing to EPA priorities in next-generation toxicity testing and predictive toxicology.
When was the opportunity posted and when was it due?
The opportunity was posted on January 28, 2011, and the application closing date was May 5, 2011.
Is this opportunity still open?
No. The opportunity was archived on June 4, 2011.
Where are submission logistics and any date nuances described?
The announcement indicates that submission logistics and any date nuances are referenced in Section IV of the full announcement.
Who can I contact with questions about eligibility?
For eligibility questions, the contact listed is James Gentry at 703-347-8093.
Who can I contact for electronic submission issues?
For electronic submission issues, the contact listed is Ron Josephson at 703-308-0442.
Who can I contact with technical questions about the research topic?
For technical questions about the research topic, the contact listed is Pasky Pascual at 703-347-8056.
What makes a proposal "defensible" for EPA decision contexts, based on this description?
The description indicates defensibility is tied to selecting assay systems that are informative for regulatory or environmental decision contexts, including relevance to humans and/or species important for ecological risk assessment, and generating outputs that can be used in predictive models for risk assessment.
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