Opportunity Information: Apply for RFA HL 12 035
Apply for RFA HL 12 035
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Early Cystic Fibrosis Lung Disease Studies in Humans, NHLBI (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.838 Lung Diseases Research.
- This funding opportunity was created on Aug 19, 2011 and posted on Aug 19, 2011.
- Applicants must submit their applications by Jan 11, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $400,000.00 in funding.
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Small businesses Native American tribal governments (Federally recognized) For profit organizations other than small businesses Public and State controlled institutions of higher education County governments Public housing authorities/Indian housing authorities State governments Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The funding opportunity Early Cystic Fibrosis Lung Disease Studies in Humans, NHLBI (R01) (RFA-HL-12-035) is a National Institutes of Health (NIH) research grant announcement issued by the National Heart, Lung, and Blood Institute (NHLBI). It uses the R01 Research Project Grant mechanism and is focused specifically on human studies that examine how cystic fibrosis (CF) lung disease begins early in life and why it progresses in some children faster or more severely than others. The central emphasis is on infants and young children with CF, with the aim of understanding the earliest biological events that set lung disease in motion, and translating that knowledge into better ways to recognize, prevent, and treat lung damage before it becomes established.
Scientifically, the announcement is aimed at projects that investigate the early origins of CF lung disease and the mechanisms driving the development and progression of pulmonary abnormalities in young children. The FOA encourages applicants to look closely at molecular and cellular processes involved in early disease, using approaches that can reveal how inflammation, infection, airway obstruction, mucus changes, immune responses, and other CF-related pathways contribute to the first detectable signs of lung injury. A key theme is connecting early detection methods with mechanistic insight, meaning that proposed tools for identifying early disease should ideally also help explain what is happening biologically as disease emerges and advances.
A major area of interest is the development and application of novel strategies to detect early CF lung disease in infants and young children. The FOA explicitly highlights minimally invasive biomarkers and imaging approaches. In practical terms, this could include identifying measurable indicators in biological samples that can be obtained with minimal burden (for example, blood-based, urine-based, breath-based, or other low-risk sampling methods), as well as imaging techniques or imaging-derived measures that can detect subtle early structural or functional abnormalities. The intent is not only to create better early-warning signals, but also to use these measures in well-designed human studies to map the trajectory of early lung disease and to identify targets for earlier intervention.
The overall public health goal stated in the FOA is the development of novel approaches for diagnosis, prevention, and treatment of early CF lung disease. In other words, NHLBI is trying to push the field upstream: instead of waiting until clear lung damage is present, the institute is supporting research that can identify the earliest changes, clarify the drivers of progression, and inform interventions that could preserve lung health longer and improve outcomes across the lifespan.
From an administrative and funding standpoint, this is a discretionary grant opportunity with no cost sharing or matching requirement. The opportunity was posted and created on August 19, 2011, with an original and current application closing date of January 11, 2012, and an archive date of February 11, 2012 (meaning it is no longer active for submission, but remains available as a record). The estimated total funding for the announcement is listed as $3,000,000, with an award ceiling of $400,000. The CFDA number associated with this program is 93.838 (Lung Diseases Research).
Eligibility is broad and includes a wide range of organization types. Eligible applicants include public and private institutions of higher education; nonprofit organizations (both with and without 501(c)(3) status, other than institutions of higher education); for-profit organizations (including small businesses and other for-profit entities); and multiple levels of government such as state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The FOA also notes eligibility for Native American tribal governments (federally recognized) and Native American tribal organizations (other than federally recognized tribal governments), along with regional organizations. It further clarifies additional eligible applicants such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, U.S. territories or possessions, and eligible federal agencies. Importantly for international collaboration, non-U.S. entities (foreign institutions) are eligible to apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined by NIH policy.
For applicants seeking the official announcement language, requirements, and any detailed scientific priorities or application instructions that were in force during the active period of the FOA, the full notice is linked through the NIH grants website at http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-12-035.html. The contact information provided in the source data directs technical access or linking issues to the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the name and identifier of this funding opportunity?
The opportunity is titled Early Cystic Fibrosis Lung Disease Studies in Humans, NHLBI (R01) and it is identified as RFA-HL-12-035.
Which agency and institute issued this announcement?
This is a National Institutes of Health (NIH) research grant announcement issued by the National Heart, Lung, and Blood Institute (NHLBI).
What grant mechanism is used?
The announcement uses the R01 Research Project Grant mechanism.
What is the main research focus of the FOA?
The FOA focuses on human studies that examine how cystic fibrosis (CF) lung disease begins early in life and why it progresses faster or more severely in some children than in others. The emphasis is on understanding the earliest biological events that initiate lung disease and translating that knowledge into better ways to recognize, prevent, and treat early lung damage.
Which patient populations are emphasized?
The central emphasis is on infants and young children with cystic fibrosis.
Is this opportunity limited to human studies?
Yes. The announcement is described as being focused specifically on human studies.
What kinds of scientific questions does NHLBI want applicants to address?
Projects are aimed at investigating the early origins of CF lung disease and the mechanisms driving the development and progression of pulmonary abnormalities in young children. This includes studying early molecular and cellular processes and how CF-related pathways contribute to the first detectable signs of lung injury.
What biological or disease processes are specifically mentioned as areas of interest?
The FOA encourages approaches that can reveal how processes such as inflammation, infection, airway obstruction, mucus changes, and immune responses (and other CF-related pathways) contribute to early lung injury.
What is meant by connecting early detection methods with mechanistic insight?
A key theme is that tools for identifying early disease should ideally also help explain what is happening biologically as disease emerges and advances. In other words, detection approaches are encouraged when they also provide insight into underlying mechanisms.
Does the FOA encourage development of new early detection strategies?
Yes. A major area of interest is the development and application of novel strategies to detect early CF lung disease in infants and young children.
What kinds of early detection approaches are explicitly highlighted?
The FOA explicitly highlights minimally invasive biomarkers and imaging approaches, including imaging-derived measures that can detect subtle early structural or functional abnormalities.
What examples of minimally invasive biomarkers are suggested?
The FOA describes measurable indicators from biological samples that can be obtained with minimal burden, such as blood-based, urine-based, breath-based, or other low-risk sampling methods.
How are biomarkers and imaging expected to be used in the proposed research?
The intent is not only to create earlier warning signals, but also to use these measures in well-designed human studies to map the trajectory of early lung disease and to identify potential targets for earlier intervention.
What is the stated public health goal of the FOA?
The stated public health goal is to develop novel approaches for the diagnosis, prevention, and treatment of early CF lung disease, with an emphasis on intervening before lung damage becomes established.
Is cost sharing or matching required?
No. The opportunity is described as having no cost sharing or matching requirement.
What is the estimated total funding amount listed for this announcement?
The estimated total funding is listed as $3,000,000.
What is the award ceiling?
The award ceiling is listed as $400,000.
What is the CFDA number associated with this program?
The CFDA number is 93.838, described as Lung Diseases Research.
When was this funding opportunity posted and created?
The opportunity was posted and created on August 19, 2011.
What was the application closing date?
The original and current application closing date was January 11, 2012.
Is this FOA still active for submission?
No. The archive date is listed as February 11, 2012, which indicates it is no longer active for submission and remains available as a record.
Who is eligible to apply?
Eligibility is described as broad and includes many organization types, including:
- Public and private institutions of higher education
- Nonprofit organizations (with and without 501(c)(3) status, other than institutions of higher education)
- For-profit organizations (including small businesses and other for-profit entities)
- State, county, and city/township governments
- Special district governments
- Independent school districts
- Public housing authorities/Indian housing authorities
- Native American tribal governments (federally recognized)
- Native American tribal organizations (other than federally recognized tribal governments)
- Regional organizations
- U.S. territories or possessions
- Eligible federal agencies
Are minority-serving institutions and community-based organizations included in eligibility?
Yes. The FOA specifically notes eligibility for organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations.
Are non-U.S. (foreign) entities allowed to apply?
Yes. The FOA states that non-U.S. entities (foreign institutions) are eligible to apply. It also states that non-U.S. components of U.S. organizations are eligible, and that foreign components are allowed as defined by NIH policy.
Where can applicants find the official announcement text and requirements?
The full notice is linked through the NIH grants website at: http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-12-035.html.
Who should be contacted for technical access or linking issues related to the FOA notice?
Technical access or linking issues are directed to the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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