Opportunity Information: Apply for RFA RM 10 015

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Economics of Prevention (R21)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
  • This funding opportunity was created on Aug 13, 2010 and posted on Aug 13, 2010.
  • Applicants must submit their applications by Oct 26, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $1,200,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • The number of recipients for this funding is limited to 6 candidate(s).
  • Eligible applicants include: Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) County governments Native American tribal governments (Federally recognized) Independent school districts City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities For profit organizations other than small businesses Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Public and State controlled institutions of higher education Private institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

The National Institutes of Health (NIH) offered the "Economics of Prevention (R21)" funding opportunity (RFA-RM-10-015) to support early-stage, exploratory research that applies economic analysis to prevention and health. The main goal is to generate evidence about how prevention affects costs and outcomes, not just within the health care system, but across the broader economy as well. Projects are expected to focus on economic questions such as what prevention costs, what savings or other benefits it produces, and whether those gains justify the investment when compared to alternatives. To be considered responsive, an application needed to clearly align with one of four specified topic areas, all centered on prevention and health and emphasizing health care costs, benefits to health care and non-health sectors, and cost-effectiveness.

This opportunity used the NIH R21 mechanism, which is typically designed for exploratory or developmental studies that can open up new lines of inquiry or produce proof-of-concept findings. In practical terms, that means the program was looking for well-reasoned, innovative projects that could meaningfully advance knowledge in the economics of prevention, even if the work was not yet at the scale of a large, definitive trial or multi-year program evaluation. The maximum award amount listed was $200,000, and there was no cost-sharing or matching requirement, meaning applicants were not required to bring additional non-federal funds to support the project.

NIH set aside an estimated total of $1.2 million for this announcement and anticipated making about six awards, with the final number dependent on the quality and merit of the applications received. The activity category is health, and the CFDA number associated with the opportunity is 93.310 (NIH Research Support). In essence, it was a relatively targeted pool of funds meant to produce a small cohort of rigorous economic studies that could clarify the value proposition of prevention strategies and inform policy, clinical practice, or program design.

Eligibility was broad and included many types of organizations. Applicants could come from public and private institutions of higher education, state and local governments (including county and city/township governments), independent school districts, special district governments, and a wide range of nonprofit and for-profit entities (including small businesses). The eligibility list also extended to public housing authorities/Indian housing authorities and multiple categories of mission-serving institutions and community-based organizations. Additional eligible applicants included Alaska Native and Native Hawaiian Serving Institutions, Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, U.S. territories or possessions, regional organizations, and even non-U.S. entities (foreign organizations). This wide eligibility reflects an intent to attract economics and prevention expertise wherever it exists, including in policy, academic, community, and international settings.

Key dates for the opportunity show it was posted and created on August 13, 2010, with an original and final closing date of October 26, 2010. The archive date was November 26, 2010. NIH provided an additional information link to the full announcement on the NIH grants website, and for access or technical issues, applicants were directed to contact the NIH Office of Extramural Research (OER) webmaster via the provided email addresses.

Overall, this FOA was designed to build practical, decision-relevant evidence on prevention by funding focused economic analyses. Successful projects would be those that clearly connect prevention activities to measurable economic outcomes, quantify tradeoffs and value (including cost-effectiveness where appropriate), and produce insights useful to decision-makers in health care and other sectors affected by population health.

Frequently Asked Questions (FAQs)

What is the name of this NIH funding opportunity?

The opportunity is titled "Economics of Prevention (R21)" and is identified as RFA-RM-10-015.

What is the main purpose of the Economics of Prevention (R21) opportunity?

The purpose is to support early-stage, exploratory research that applies economic analysis to prevention and health. The emphasis is on generating evidence about how prevention affects costs and outcomes both within the health care system and across the broader economy.

What types of questions were projects expected to answer?

Projects were expected to address practical economic questions about prevention, such as what prevention costs, what savings or other benefits it produces, and whether those gains justify the investment compared to alternative options. The FOA also emphasized value and tradeoffs, including cost-effectiveness where appropriate.

What does it mean that this was an NIH R21?

This opportunity used the NIH R21 mechanism, which is typically intended for exploratory or developmental studies. In practice, it targets innovative, well-reasoned projects that can open new lines of inquiry or provide proof-of-concept findings, even if they are not large, definitive trials or multi-year program evaluations.

How much funding could an applicant request?

The maximum award amount listed for this opportunity was $200,000.

Was cost-sharing or matching required?

No. The announcement stated there was no cost-sharing or matching requirement, meaning applicants were not required to contribute additional non-federal funds to support the project.

How much total funding did NIH plan to make available?

NIH set aside an estimated total of $1.2 million for this announcement.

How many awards did NIH expect to make?

NIH anticipated making about six awards, with the final number depending on the quality and merit of the applications received.

What topic focus was required for an application to be considered responsive?

To be considered responsive, an application needed to clearly align with one of four specified topic areas. These topic areas were all centered on prevention and health and emphasized health care costs, benefits to health care and non-health sectors, and cost-effectiveness.

What sector or activity category does this opportunity fall under?

The activity category for this opportunity is health.

What is the CFDA number for this opportunity?

The CFDA number associated with the opportunity is 93.310 (NIH Research Support).

Who was eligible to apply?

Eligibility was broad. Eligible applicants included public and private institutions of higher education; state and local governments (including county and city/township governments); independent school districts; special district governments; nonprofit and for-profit organizations (including small businesses); public housing authorities/Indian housing authorities; and various mission-serving institutions and community-based organizations.

Were specific institution types like HBCUs, HSIs, and tribal colleges eligible?

Yes. The eligibility list included Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and other mission-serving institutions.

Were faith-based or community-based organizations eligible?

Yes. Faith-based or community-based organizations were explicitly included among eligible applicants.

Could federal agencies apply?

Yes. Eligible applicants included eligible federal agencies.

Were U.S. territories or possessions eligible?

Yes. The eligibility list included U.S. territories or possessions, as well as regional organizations.

Were foreign (non-U.S.) organizations eligible to apply?

Yes. The eligibility list stated that non-U.S. entities (foreign organizations) were eligible.

When was the opportunity posted?

The opportunity was posted and created on August 13, 2010.

What was the application deadline?

The original closing date and the final closing date were both October 26, 2010.

When was the opportunity archived?

The archive date was November 26, 2010.

Where could applicants find the full announcement?

NIH provided an additional information link to the full announcement on the NIH grants website.

Who should applicants contact for access or technical issues related to the posting?

For access or technical issues, applicants were directed to contact the NIH Office of Extramural Research (OER) webmaster via the provided email addresses.

What kind of outputs or outcomes was NIH looking for from funded projects?

The FOA aimed to produce practical, decision-relevant evidence on prevention by funding focused economic analyses. Successful projects would clearly connect prevention activities to measurable economic outcomes, quantify tradeoffs and value (including cost-effectiveness where appropriate), and generate insights useful to decision-makers in health care and other sectors influenced by population health.

Why did the FOA emphasize impacts beyond the health care system?

The stated goal was to understand how prevention affects costs and outcomes not only in health care, but across the broader economy. This reflects an interest in benefits and costs that may appear in non-health sectors as well.

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