Opportunity Information: Apply for RFA DE 12 006
Apply for RFA DE 12 006
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Effectiveness of Treatment for Oral Diseases in Medically Compromised Patients (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research.
- This funding opportunity was created on Jun 28, 2011 and posted on Jun 28, 2011.
- Applicants must submit their applications by Sep 18, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
- Eligible applicants include: State governments Special district governments City or township governments Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) County governments Independent school districts Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign (non U.S.) components of U.S. Organizations are allowed.
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Opportunity Summary:
The grant opportunity titled "Effectiveness of Treatment for Oral Diseases in Medically Compromised Patients (R01)" (Funding Opportunity Number RFA-DE-12-006) is a discretionary National Institutes of Health (NIH) research grant that supports studies focused on how well prevention and treatment strategies work for oral diseases in people whose underlying medical conditions significantly increase their risk of oral health problems. The central aim is to generate evidence about real outcomes of oral disease interventions when they are used in medically complex patients, where standard dental approaches may be less effective, harder to deliver, or associated with different risks and complications than in otherwise healthy populations.
This opportunity uses the NIH R01 mechanism, meaning it is intended for hypothesis-driven, investigator-initiated research projects that can rigorously evaluate clinical outcomes. The emphasis is on determining the effectiveness of prevention or treatment strategies for oral diseases and disorders in individuals with medical conditions known to severely compromise oral health. In practical terms, this points to research that measures meaningful endpoints, such as disease progression or control, treatment success rates, complications, patient-centered outcomes, and potentially how medical comorbidities change the balance of benefits and harms for specific oral health interventions. While the short description does not list specific diseases or conditions, the intent is clearly oriented toward medically compromised populations where oral disease risk and treatment complexity are elevated, and where evidence is often limited or not directly transferable from healthier groups.
The activity category is Health, and the associated CFDA number is 93.121, which corresponds to Oral Diseases and Disorders Research. The FOA does not require cost sharing or matching, which means applicants are not expected to provide non-federal funds as a condition of the award. NIH listed an estimated total funding amount of $4,000,000 for the program, indicating a multi-award research portfolio rather than a single project, although the exact number and size of awards would typically depend on application quality, requested budgets, and NIH priorities at the time.
A wide range of organizations were eligible to apply. Eligible applicants included various levels of government (state, county, city/township, special districts), public and private institutions of higher education, nonprofit organizations both with and without 501(c)(3) status, for-profit organizations (including small businesses and other for-profits), independent school districts, and public or Indian housing authorities. The eligibility scope also explicitly extended to federally recognized tribal governments and other tribal organizations, as well as a number of institution types that commonly participate in federal research funding such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions. Faith-based and community-based organizations were included as eligible agencies of the federal government. Importantly, the FOA allowed participation by non-U.S. entities (foreign organizations), regional organizations, U.S. territories or possessions, and foreign components of U.S. organizations, which signals that NIH was open to internationally relevant expertise and study settings where medically compromised populations and oral disease burdens may be significant.
Key timing details reflect that this was a time-limited solicitation. The FOA was posted and created on June 28, 2011. The original and current closing date was September 18, 2012, and the archive date was October 19, 2012, meaning the announcement is no longer active but remains accessible for historical reference. For applicants or researchers trying to locate the full text, NIH provided an additional information link to the official NIH grants guide page for RFA-DE-12-006. For access or technical issues, the contact route was the NIH Office of Extramural Research (OER) webmaster.
Overall, this R01 opportunity was designed to strengthen the evidence base for oral disease prevention and treatment specifically in medically compromised patients, where oral health needs are often greater, clinical decision-making can be more complicated, and outcomes may differ from those observed in the general population.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "Effectiveness of Treatment for Oral Diseases in Medically Compromised Patients (R01)."
What is the funding opportunity number (FOA number)?
The funding opportunity number is RFA-DE-12-006.
Which federal agency is offering this grant?
This is a National Institutes of Health (NIH) discretionary research grant opportunity.
What type of grant mechanism does this opportunity use?
It uses the NIH R01 mechanism, which is intended for hypothesis-driven, investigator-initiated research projects that can rigorously evaluate outcomes.
What is the main purpose of this FOA?
The central aim is to generate evidence on how well prevention and treatment strategies for oral diseases work when used in medically compromised patients, where standard dental approaches may be less effective, harder to deliver, or associated with different risks and complications than in otherwise healthy populations.
What kinds of studies are emphasized under this opportunity?
The FOA emphasizes research that determines the effectiveness of prevention or treatment strategies for oral diseases and disorders in individuals with medical conditions known to severely compromise oral health, using rigorous evaluation of clinical outcomes.
Who are considered "medically compromised patients" in the context of this FOA?
Based on the provided description, the term refers to people whose underlying medical conditions significantly increase their risk of oral health problems and can make oral disease prevention or treatment more complex, less effective, or riskier than in healthier populations.
What outcomes or endpoints does the FOA encourage applicants to measure?
The description highlights meaningful endpoints such as disease progression or control, treatment success rates, complications, patient-centered outcomes, and how medical comorbidities may change the balance of benefits and harms for specific oral health interventions.
Does the FOA list specific oral diseases or specific medical conditions to study?
No. The short description does not list specific diseases or conditions, but it is clearly oriented toward medically compromised populations where oral disease risk and treatment complexity are elevated and evidence is often limited or not directly transferable from healthier groups.
What is the activity category for this opportunity?
The activity category is Health.
What is the CFDA number associated with this program?
The associated CFDA number is 93.121 (Oral Diseases and Disorders Research).
Is cost sharing or matching required?
No. The FOA does not require cost sharing or matching, meaning applicants are not expected to provide non-federal funds as a condition of the award.
How much total funding did NIH estimate for this program?
NIH listed an estimated total funding amount of $4,000,000.
Is this funding intended for one award or multiple awards?
The estimated total funding suggests a multi-award research portfolio rather than a single project. The exact number and size of awards would typically depend on application quality, requested budgets, and NIH priorities at the time.
What types of organizations were eligible to apply?
Eligible applicants included state, county, city/township, and special district governments; public and private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status); for-profit organizations (including small businesses and other for-profits); independent school districts; and public or Indian housing authorities.
Were tribal governments or tribal organizations eligible?
Yes. The eligibility scope explicitly included federally recognized tribal governments and other tribal organizations.
Were minority-serving institutions included in eligibility?
Yes. The eligibility list explicitly included institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions.
Were faith-based or community-based organizations eligible?
Yes. Faith-based and community-based organizations were included as eligible agencies of the federal government, as described in the provided information.
Could foreign (non-U.S.) organizations apply?
Yes. The FOA allowed participation by non-U.S. entities (foreign organizations), regional organizations, U.S. territories or possessions, and foreign components of U.S. organizations.
When was this FOA posted?
The FOA was posted and created on June 28, 2011.
What was the application closing date?
The original and current closing date was September 18, 2012.
Is this FOA still active?
No. The archive date was October 19, 2012, which indicates the announcement is no longer active and is retained for historical reference.
Where can applicants find the official NIH posting for this FOA?
NIH provided an additional information link to the official NIH grants guide page for RFA-DE-12-006.
Who was listed for help with access or technical issues?
For access or technical issues, the contact route was the NIH Office of Extramural Research (OER) webmaster.
What is the overall goal of this research program in practical terms?
The overall goal is to strengthen the evidence base for oral disease prevention and treatment specifically in medically compromised patients, where oral health needs are often greater, clinical decision-making can be more complicated, and real-world outcomes may differ from those observed in the general population.
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