Opportunity Information: Apply for RFA DE 12 007
Apply for RFA DE 12 007
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Effectiveness of Treatment for Oral Diseases in Medically Compromised Patients (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research.
- This funding opportunity was created on Jun 28, 2011 and posted on Jun 28, 2011.
- Applicants must submit their applications by Sep 18, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Special district governments Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments County governments Private institutions of higher education For profit organizations other than small businesses Public and State controlled institutions of higher education City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign (non U.S.) components of U.S. Organizations are allowed.
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Opportunity Summary:
The NIH funding opportunity RFA-DE-12-007, titled "Effectiveness of Treatment for Oral Diseases in Medically Compromised Patients (R21)," was a discretionary grant program in the health research area (CFDA 93.121, Oral Diseases and Disorders Research). It was designed to support exploratory and developmental clinical research that tests and clarifies how well prevention and treatment approaches work for oral diseases in people whose medical conditions are known to seriously harm oral health. In practical terms, the program was looking for early-stage, outcomes-focused clinical studies that help determine whether particular strategies actually improve oral health (and potentially related health outcomes) in patient groups that are medically complex and often underrepresented in traditional dental clinical trials.
A key theme of the announcement is effectiveness in real-world or clinically relevant settings, rather than basic science discovery alone. The intent was to encourage studies that evaluate outcomes of interventions such as preventive regimens, therapeutic treatments, or management strategies for oral diseases when patients also have systemic illnesses or conditions that complicate care. These are the kinds of situations where standard dental approaches may perform differently because of factors like immune suppression, medication side effects, altered wound healing, higher infection risk, xerostomia, or barriers to accessing routine dental services. The R21 mechanism signals that NIH was aiming to stimulate innovative, pilot-scale clinical investigations that generate feasibility data, early estimates of effect, and clear direction for larger confirmatory trials later on.
From a funding and project-size standpoint, the opportunity listed an award ceiling of $200,000 and an estimated total program funding level of $4,000,000. Cost sharing or matching was not required, which typically lowers barriers to participation and can be especially important for smaller organizations or safety-net providers that serve medically compromised populations.
Eligibility was broad and included a wide range of domestic and international organizations. Eligible applicants included public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (both 501(c)(3) and non-501(c)(3), excluding those classified as institutions of higher education in that category), small businesses, and other for-profit organizations. Multiple levels of government were eligible as well, including state, county, city/township, special district governments, and certain housing authorities. The announcement also explicitly included federally recognized Native American tribal governments and other tribal organizations, plus a variety of mission-specific institutions and organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based and community-based organizations, regional organizations, and eligible agencies of the federal government. Importantly, non-U.S. entities (foreign organizations) were allowed, and foreign components of U.S. organizations were also permitted, which suggests NIH was open to relevant clinical research contexts outside the United States when scientifically justified.
Administratively, the opportunity was posted on June 28, 2011, with an original and final application closing date of September 18, 2012, and an archive date of October 19, 2012, meaning it is no longer active. The sponsoring agency was the National Institutes of Health. For access and technical issues related to the full announcement, the contact provided was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV, and an additional information link was supplied to the NIH grants guide page for the full RFA text.
Overall, this FOA was aimed at accelerating practical clinical knowledge about what prevention and treatment methods actually work for oral diseases when patients have serious comorbid medical conditions. By using the R21 exploratory mechanism, NIH was signaling interest in innovative, hypothesis-generating, and feasibility-oriented clinical studies that could lay the groundwork for larger-scale trials and, ultimately, better clinical guidance for caring for medically compromised patients whose oral health is at high risk.
FAQs: NIH RFA-DE-12-007 - Effectiveness of Treatment for Oral Diseases in Medically Compromised Patients (R21)
What is RFA-DE-12-007?
RFA-DE-12-007 is an NIH funding opportunity announcement titled "Effectiveness of Treatment for Oral Diseases in Medically Compromised Patients (R21)." It was a discretionary grant program supporting exploratory and developmental clinical research on prevention and treatment approaches for oral diseases in medically compromised patient populations.
What NIH mechanism does this opportunity use?
This opportunity used the R21 mechanism, which is intended for exploratory and developmental research. In this context, it signaled an interest in innovative, pilot-scale clinical studies that can generate feasibility data, early estimates of effect, and direction for later, larger confirmatory trials.
What is the main purpose of this funding opportunity?
The purpose was to test and clarify how well oral disease prevention and treatment approaches work for people whose medical conditions are known to seriously harm oral health. The emphasis was on effectiveness and outcomes in real-world or clinically relevant settings.
What types of studies were this program trying to encourage?
The program was designed to support early-stage, outcomes-focused clinical research that evaluates whether specific strategies improve oral health (and potentially related health outcomes) in medically complex patient groups that are often underrepresented in traditional dental clinical trials.
Does the FOA focus on basic science or clinical effectiveness?
The key theme was clinical effectiveness in real-world or clinically relevant settings, rather than basic science discovery alone.
What kinds of interventions were in scope?
Interventions described as in scope included preventive regimens, therapeutic treatments, and management strategies for oral diseases, specifically when patients also have systemic illnesses or other conditions that complicate dental care.
Why does the FOA emphasize medically compromised patients?
The FOA highlighted that standard dental approaches may perform differently in medically compromised populations due to factors such as immune suppression, medication side effects, altered wound healing, higher infection risk, xerostomia, or barriers to accessing routine dental services.
What clinical settings or context did NIH want to see?
The announcement emphasized studies in real-world or clinically relevant settings, aiming to produce practical evidence about what works in the kinds of care contexts medically compromised patients actually experience.
What is the CFDA number and program area for this opportunity?
The CFDA listing was 93.121, "Oral Diseases and Disorders Research," in the health research area.
What was the maximum award amount?
The award ceiling listed for this opportunity was $200,000.
What was the estimated total program funding?
The estimated total program funding level was $4,000,000.
Was cost sharing or matching required?
No. The opportunity stated that cost sharing or matching was not required.
Who was eligible to apply?
Eligibility was broad and included a wide range of domestic and international organizations. Eligible applicants included public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (501(c)(3) and non-501(c)(3), excluding those classified as institutions of higher education in that category), small businesses, other for-profit organizations, and multiple levels of government.
Which government entities were eligible?
Eligible government entities included state governments, county governments, city or township governments, special district governments, and certain housing authorities. Eligible agencies of the federal government were also included.
Were tribal governments and tribal organizations eligible?
Yes. The announcement explicitly included federally recognized Native American tribal governments and other tribal organizations.
Were minority-serving or mission-specific institutions included in eligibility?
Yes. The eligibility list explicitly included Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions, among others.
Could faith-based or community-based organizations apply?
Yes. Faith-based and community-based organizations were explicitly included as eligible applicants.
Could non-U.S. (foreign) organizations apply?
Yes. Non-U.S. entities (foreign organizations) were allowed, and foreign components of U.S. organizations were also permitted, indicating NIH openness to scientifically justified research contexts outside the United States.
When was the opportunity posted and when did it close?
The opportunity was posted on June 28, 2011. The original and final application closing date was September 18, 2012.
Is this funding opportunity still active?
No. The archive date was October 19, 2012, meaning the announcement is no longer active.
Which agency sponsored this funding opportunity?
The sponsoring agency was the National Institutes of Health (NIH).
Where could applicants find the full RFA text?
An additional information link was provided to the NIH grants guide page where the full RFA text could be accessed.
Who was the contact for access or technical issues related to the full announcement?
The contact listed for access and technical issues was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What kind of results was NIH hoping these R21 projects would produce?
The FOA emphasized feasibility data, early estimates of effect, and clear direction for larger confirmatory trials later on, with the overall goal of improving practical clinical knowledge about prevention and treatment for oral diseases in medically compromised patients.
Why might this FOA be important for safety-net providers or smaller organizations?
The announcement stated that cost sharing or matching was not required, which can lower barriers to participation for smaller organizations and providers serving medically compromised populations.
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