Opportunity Information: Apply for RFA HL 10 020
Apply for RFA HL 10 020
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Effectiveness Research on Smoking Cessation in Hospitalized Patients (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs 93.399 Cancer Control 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research.
- This funding opportunity was created on Nov 16, 2009 and posted on Nov 16, 2009.
- Applicants must submit their applications by Jan 19, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $21,100,000.00 to eligible and selected applicants.
- Eligible applicants include: County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities State governments For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Small businesses Independent school districts Special district governments Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The funding opportunity titled "Effectiveness Research on Smoking Cessation in Hospitalized Patients (U01)" (Funding Opportunity Number RFA-HL-10-020) is a National Institutes of Health (NIH) cooperative agreement announcement led by the National Heart, Lung, and Blood Institute (NHLBI), with participation from the National Institute on Drug Abuse (NIDA) and the National Cancer Institute (NCI). Its central goal is to support real-world, effectiveness-focused research on smoking cessation interventions that begin while a patient is hospitalized and continue after discharge. The program is built on the practical insight that hospitalization can be a powerful "teachable moment" for quitting smoking, but that outcomes depend heavily on sustained support once patients leave the hospital. While many inpatient cessation approaches have shown efficacy, the FOA is specifically focused on translating those strategies into interventions that actually work across routine clinical settings and can be implemented widely, not just under ideal research conditions.
The purpose of the FOA is twofold. First, it encourages studies that test how well evidence-based cessation strategies perform when delivered through typical hospital workflows, staffing models, and patient populations. This emphasis on translation means applicants are expected to grapple with variability in hospital practices, differences in patient acuity and readiness to quit, and the logistical challenges of ensuring continuity of care after discharge. Second, the FOA explicitly calls for cost-effectiveness assessment, signaling that the agencies want results that help health systems and policymakers understand not only whether an approach improves quit rates, but also whether it is financially and operationally sensible at scale. A key programmatic idea embedded in the description is that inpatient interventions appear most successful when paired with at least one month of post-discharge cessation support, so projects are expected to incorporate and evaluate that continuation component.
This announcement uses the Cooperative Agreement (U01) mechanism, which is designed for projects where NIH expects to have substantial scientific or programmatic involvement during the award. In practice, that often means closer coordination between NIH staff and funded research teams than would occur under a standard research project grant, especially when studies are multi-site, require harmonized methods, or are intended to produce generalizable implementation-ready evidence. The FOA also notes a companion announcement (RFA-HL-10-025) that solicits a separate U01 for a Research Coordinating Unit. That coordinating unit is intended to support cross-awardee collaboration, help standardize procedures and measures where appropriate, and coordinate shared activities among the intervention study sites funded under this FOA.
Funding is relatively substantial and is organized across the three participating institutes. NHLBI planned to provide about $13.5 million in total costs over four years to support roughly three to four awards. NIDA and NCI each planned about $3.8 million in total costs over four years to support approximately one award each. Combined, the participating institutes projected approximately $21.1 million in total costs over four years to support an estimated five to six awards in total. As with many federal funding announcements, awards were contingent on the availability of funds and the submission of enough high-quality, meritorious applications.
Eligibility is broad and includes a wide range of organization types that could realistically run hospital-based effectiveness studies. Eligible applicants include public and private institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3)), for-profit organizations (other than small businesses), small businesses, and multiple levels of government (state, county, city/township, special district). It also includes public housing authorities/Indian housing authorities, independent school districts, tribal governments (both federally recognized and other than federally recognized), and tribal organizations. The eligibility section further highlights inclusion of entities such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. No cost sharing or matching requirement is indicated.
From an administrative standpoint, the FOA was posted and created on November 16, 2009, with an original and current closing date of January 19, 2010, and an archive date of February 19, 2010. The opportunity is categorized as discretionary and lists activity and CFDA program associations spanning drug abuse and addiction research, cancer control, and cardiovascular and lung diseases research (CFDA 93.279, 93.399, 93.837, 93.838), reflecting the cross-cutting health impact of smoking and tobacco dependence across major disease areas. For technical issues accessing the announcement, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this grant?
The opportunity is titled "Effectiveness Research on Smoking Cessation in Hospitalized Patients (U01)" and the Funding Opportunity Number is RFA-HL-10-020.
Which agencies and institutes are involved in this funding opportunity?
This is a National Institutes of Health (NIH) cooperative agreement announcement led by the National Heart, Lung, and Blood Institute (NHLBI), with participation from the National Institute on Drug Abuse (NIDA) and the National Cancer Institute (NCI).
What is the central goal of this funding opportunity?
The goal is to support real-world, effectiveness-focused research on smoking cessation interventions that start while a patient is hospitalized and continue after discharge.
What kind of research does the FOA emphasize: efficacy or effectiveness?
The FOA emphasizes effectiveness research in routine clinical settings. It focuses on translating evidence-based inpatient cessation strategies into interventions that work across typical hospital workflows and patient populations, rather than under ideal research conditions.
Why does the FOA focus on hospitalized patients?
The program is built on the practical insight that hospitalization can be a powerful "teachable moment" for quitting smoking, but that quit outcomes depend heavily on sustained support once patients leave the hospital.
What are the two main purposes of the FOA?
First, it encourages studies testing how well evidence-based cessation strategies perform when delivered through typical hospital workflows, staffing models, and real-world patient populations. Second, it explicitly calls for cost-effectiveness assessment to help determine whether approaches are financially and operationally sensible at scale.
Does the FOA require post-discharge support as part of the intervention?
The FOA highlights that inpatient interventions appear most successful when paired with at least one month of post-discharge cessation support, and projects are expected to incorporate and evaluate a continuation component after discharge.
What types of real-world challenges are applicants expected to address?
Applicants are expected to grapple with variability in hospital practices, differences in patient acuity and readiness to quit, and logistical challenges in maintaining continuity of care after discharge.
Does the FOA require or encourage cost-effectiveness analysis?
Yes. The FOA explicitly calls for cost-effectiveness assessment, indicating interest in both improved quit outcomes and the practicality of implementing interventions widely across health systems.
What funding mechanism is used for this opportunity?
This announcement uses the Cooperative Agreement (U01) mechanism.
What does a U01 cooperative agreement imply about NIH involvement?
A U01 is designed for projects where NIH expects substantial scientific or programmatic involvement during the award, which often means closer coordination between NIH staff and funded research teams than would occur under a standard research project grant.
Is there a coordinating component associated with this program?
Yes. The FOA notes a companion announcement (RFA-HL-10-025) that solicits a separate U01 for a Research Coordinating Unit intended to support cross-awardee collaboration and coordinate shared activities among intervention study sites funded under this FOA.
What is the purpose of the Research Coordinating Unit mentioned in the FOA?
The coordinating unit is intended to support collaboration across awardees, help standardize procedures and measures where appropriate, and coordinate shared activities among the intervention study sites.
How much total funding was planned and over what time period?
Across the participating institutes, approximately $21.1 million in total costs over four years was projected.
How is the planned funding distributed among the participating institutes?
NHLBI planned about $13.5 million in total costs over four years to support roughly three to four awards. NIDA planned about $3.8 million over four years to support approximately one award, and NCI planned about $3.8 million over four years to support approximately one award.
How many awards were expected under this FOA?
Approximately five to six awards in total were projected across the participating institutes.
Are awards guaranteed if an application is submitted?
No. Awards were contingent on the availability of funds and the submission of a sufficient number of meritorious applications.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education, nonprofit organizations (501(c)(3) and non-501(c)(3)), for-profit organizations (other than small businesses), small businesses, and multiple levels of government (state, county, city/township, special district). It also includes public housing authorities/Indian housing authorities, independent school districts, tribal governments (federally recognized and other than federally recognized), and tribal organizations.
Are specific institution types called out as eligible?
Yes. The eligibility section highlights entities such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
Is cost sharing or matching required?
No cost sharing or matching requirement is indicated in the provided information.
What are the key dates for this funding opportunity?
The FOA was posted/created on November 16, 2009. The original and current closing date was January 19, 2010. The archive date was February 19, 2010.
What is the opportunity category?
The opportunity is categorized as discretionary.
Which CFDA program numbers are associated with this FOA?
The FOA lists CFDA associations spanning drug abuse and addiction research, cancer control, and cardiovascular and lung diseases research: 93.279, 93.399, 93.837, and 93.838.
What is the health focus area reflected by the participating institutes and CFDA listings?
The program reflects the cross-cutting impact of smoking and tobacco dependence across major disease areas, including drug abuse/addiction, cancer control, and cardiovascular and lung diseases.
Who should be contacted for technical issues accessing the announcement?
For technical issues accessing the announcement, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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