Opportunity Information: Apply for PA 14 163
Apply for PA 14 163
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Effects of Cannabis Use and Cannabinoids on the Developing Brain (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Mar 26, 2014 and posted on Mar 26, 2014.
- Applicants must submit their applications by May 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities City or township governments Special district governments County governments State governments Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH grant opportunity "Effects of Cannabis Use and Cannabinoids on the Developing Brain (R01)" (Funding Opportunity Number PA-14-163) supports investigator-initiated Research Project Grant (R01) applications focused on how cannabis use and specific cannabinoids affect brain development and later functioning. The central purpose is to encourage rigorous, mechanistic and outcome-oriented research that clarifies what happens when exposure occurs during sensitive developmental windows, spanning prenatal, perinatal, and postnatal stages through adolescence and young adulthood. The FOA is framed broadly to include both animal model studies and human research, with an emphasis on understanding not only immediate effects but also long-term functional consequences that may emerge later in life.
The scientific scope targets the developing brain, which is often more vulnerable to perturbations in signaling pathways that guide neural proliferation, migration, synapse formation, and circuit refinement. Projects responsive to this FOA can address molecular and cellular mechanisms by which cannabis or cannabinoids alter developmental trajectories, such as changes in neurotransmitter systems, endocannabinoid signaling, gene expression, synaptic plasticity, neuroinflammation, or other biological processes that plausibly link early exposure to later cognitive or behavioral outcomes. Beyond mechanism, the FOA highlights interest in longer-term functional consequences, including impacts on learning and memory, cognition, and emotional development. In practice, this means studies may examine neurodevelopmental outcomes like attention, executive function, motivation, stress responsivity, affect regulation, and related domains, provided the work is clearly anchored to developmental exposure and brain-based endpoints.
Administratively, this is a discretionary grant opportunity from the National Institutes of Health under the Funding Instrument Type "Grant" and Funding Activity Category spanning education and health, listed under CFDA 93.279 (Drug Abuse and Addiction Research Programs). The announcement explicitly states there is no cost sharing or matching requirement, which means applicants are not expected to provide mandatory institutional matching funds as a condition of eligibility. The opportunity was posted and created on March 26, 2014, with an original closing date of May 7, 2017, and it was archived on June 7, 2017, indicating it is no longer open for new submissions under that specific announcement and timeline.
Eligibility is intentionally expansive, reflecting NIH's typical approach to soliciting high-quality research from a wide range of institutional settings. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations both with and without 501(c)(3) status (as long as they meet NIH eligibility requirements), for-profit organizations (including small businesses and other for-profit entities), and various government bodies such as state governments, county governments, city or township governments, special district governments, and independent school districts. The FOA also includes Native American tribal governments (federally recognized) and other tribal organizations, as well as public housing authorities/Indian housing authorities. Additional eligible applicants specifically called out include institutions serving historically underrepresented populations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations and eligible federal agencies.
The announcement also permits international participation: non-U.S. entities (foreign organizations and foreign institutions) are eligible to apply, non-U.S. components of U.S. organizations are eligible, and foreign components (as defined in the NIH Grants Policy Statement) are allowed. This broad eligibility aligns with the global relevance of cannabis exposure and neurodevelopmental health and recognizes that strong cohorts, specialized model systems, and complementary expertise may exist outside the United States.
For applicants or readers who need the full text, NIH provided an official link to the FOA at http://grants.nih.gov/grants/guide/pa-files/PA-14-163.html. For access or technical issues with the electronic announcement or links, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the name of this NIH grant opportunity?
The opportunity is titled "Effects of Cannabis Use and Cannabinoids on the Developing Brain (R01)."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is PA-14-163.
What type of grant mechanism does this opportunity support?
It supports investigator-initiated Research Project Grant (R01) applications.
What is the central purpose of this FOA?
The purpose is to encourage rigorous, mechanistic and outcome-oriented research that clarifies how cannabis use and specific cannabinoids affect brain development and later functioning, especially when exposure occurs during sensitive developmental windows.
Which developmental periods are covered by the FOA?
The FOA spans prenatal, perinatal, and postnatal stages through adolescence and young adulthood.
Does the FOA focus only on immediate effects of exposure?
No. It emphasizes both immediate effects and long-term functional consequences that may emerge later in life.
Are both human and animal studies allowed?
Yes. The FOA is framed broadly to include both animal model studies and human research.
What general scientific theme is emphasized in the scope?
The scope targets the developing brain, which is described as potentially more vulnerable to disruptions in signaling pathways that guide neural proliferation, migration, synapse formation, and circuit refinement.
What kinds of mechanistic topics are considered responsive?
Responsive projects can address molecular and cellular mechanisms by which cannabis or cannabinoids alter developmental trajectories, including areas such as neurotransmitter systems, endocannabinoid signaling, gene expression, synaptic plasticity, neuroinflammation, or other plausible biological processes linking early exposure to later outcomes.
What types of outcomes or functional endpoints are of interest?
The FOA highlights longer-term functional consequences, including impacts on learning and memory, cognition, and emotional development. Examples of neurodevelopmental outcomes mentioned include attention, executive function, motivation, stress responsivity, affect regulation, and related domains, as long as the work is anchored to developmental exposure and brain-based endpoints.
What is the funding instrument type?
The funding instrument type is "Grant."
What is the funding activity category listed for this opportunity?
It is listed under an activity category spanning education and health.
What CFDA program is associated with this FOA?
It is listed under CFDA 93.279 (Drug Abuse and Addiction Research Programs).
Is cost sharing or matching required?
No. The announcement explicitly states there is no cost sharing or matching requirement.
When was the opportunity posted and created?
It was posted and created on March 26, 2014.
What was the original closing date for the FOA?
The original closing date was May 7, 2017.
Is this funding opportunity still open?
No. The opportunity was archived on June 7, 2017, indicating it is no longer open for new submissions under that specific announcement and timeline.
Who is eligible to apply?
Eligibility is broad and includes public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status, as long as they meet NIH eligibility requirements), for-profit organizations (including small businesses), and government entities (state, county, city or township, special district governments, and independent school districts).
Are tribal organizations eligible?
Yes. Eligible applicants include Native American tribal governments (federally recognized) and other tribal organizations, as well as public housing authorities/Indian housing authorities.
Are institutions serving historically underrepresented populations specifically included?
Yes. The FOA specifically calls out organizations such as HBCUs, Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and AANAPISIs.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are listed as eligible applicants.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are included among eligible applicants.
Can non-U.S. organizations apply?
Yes. Non-U.S. entities (foreign organizations and foreign institutions) are eligible to apply.
Are non-U.S. components of U.S. organizations eligible?
Yes. Non-U.S. components of U.S. organizations are eligible.
Are foreign components allowed on applications?
Yes. Foreign components (as defined in the NIH Grants Policy Statement) are allowed.
Where can applicants read the official FOA text?
The official FOA is available at http://grants.nih.gov/grants/guide/pa-files/PA-14-163.html.
Who should be contacted for technical issues with the announcement or links?
The listed contact for access or technical issues is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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