Opportunity Information: Apply for RFA DK 14 023
Apply for RFA DK 14 023
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Elucidating HIV and HIV treatment Associated Metabolic/Endocrine Dysfunction (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Oct 20, 2014 and posted on Oct 20, 2014.
- Applicants must submit their applications by Apr 9, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: County governments Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Independent school districts Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH funding opportunity RFA-DK-14-023, titled "Elucidating HIV and HIV Treatment Associated Metabolic/Endocrine Dysfunction (R01)," was a discretionary research grant announcement designed to fund human-focused studies on how HIV infection and HIV care contribute to metabolic and endocrine problems. The core purpose was to support innovative projects that clarify the role of HIV itself, relevant host factors or co-existing conditions, and antiretroviral therapy (ART) in driving dysfunction across metabolic and endocrine systems. In addition to identifying mechanisms, the FOA also emphasized research aimed at understanding disease pathways and causes, pinpointing risk and protective factors, and developing or testing strategies that could prevent, treat, or even reverse these complications in people living with HIV.
A key requirement was that proposed research had to be grounded in human subjects with HIV infection, or directly use materials or data derived from HIV-infected individuals. This set the announcement apart from basic or purely animal-based work, signaling an intent to generate findings with direct clinical relevance. The funded science was expected to align with the mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), specifically the Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM). In practical terms, projects needed a strong connection to metabolic disease, endocrine dysfunction, diabetes-related pathways, or closely related metabolic/endocrine outcomes in the context of HIV and its treatment.
The award mechanism was the NIH R01, supporting investigator-initiated, multi-year research projects. The announcement listed an estimated total funding level of about $2.5 million and an award ceiling of $500,000, with no cost sharing or matching requirement. The program sat within the NIH’s broader health research activities and was cataloged under CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).
Eligibility was broad and included many types of U.S.-based institutions and organizations, such as public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), small businesses, for-profit organizations (other than small businesses), and a wide range of government entities (state, county, city/township, special district governments, independent school districts, and public housing authorities). The FOA also explicitly included several institution types and community-oriented entities, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, Asian American and Native American Pacific Islander-serving institutions, and faith-based or community-based organizations. Foreign institutions were not eligible to apply, and non-U.S. components of U.S. organizations were not eligible; however, foreign components were allowed under NIH policy definitions, meaning certain international collaborations could be included when justified and compliant with NIH rules.
Administratively, the opportunity was posted on October 20, 2014, with an application due date of April 9, 2015, and it was later archived in May 2015. The sponsoring agency was the National Institutes of Health, and the full announcement was hosted through the NIH grants guide. For technical issues accessing or linking to the announcement, the contact point listed was the NIH Office of Extramural Research (OER) webmaster.
Frequently Asked Questions (FAQs)
What is the funding opportunity RFA-DK-14-023?
RFA-DK-14-023 is an NIH research funding opportunity titled "Elucidating HIV and HIV Treatment Associated Metabolic/Endocrine Dysfunction (R01)." It was a discretionary research grant announcement focused on supporting human-centered research on metabolic and endocrine complications related to HIV infection and HIV treatment.
What is the main purpose of this NIH funding opportunity?
The main purpose was to fund innovative studies that clarify how HIV infection, host factors or co-existing conditions, and antiretroviral therapy (ART) contribute to dysfunction in metabolic and endocrine systems. The opportunity emphasized clinically relevant, human-focused research intended to improve understanding of mechanisms and pathways and to inform strategies to prevent, treat, or reverse these complications in people living with HIV.
What types of scientific questions or goals did the FOA emphasize?
Based on the description provided, the FOA emphasized projects that could:
- Identify and explain mechanisms behind metabolic and endocrine dysfunction associated with HIV and HIV treatment
- Clarify disease pathways and underlying causes in people living with HIV
- Pinpoint risk factors and protective factors
- Develop or test strategies to prevent, treat, or reverse metabolic/endocrine complications in HIV
What population or materials had to be included in the research?
A key requirement was that the proposed research had to be grounded in human subjects with HIV infection, or directly use materials or data derived from HIV-infected individuals. This requirement distinguished the opportunity from basic or purely animal-based studies.
Were animal-only or purely basic science studies responsive to this opportunity?
The announcement was positioned to support human-focused research with direct clinical relevance. Because the research had to be grounded in HIV-infected human subjects or use human-derived materials/data, purely animal-based work would not meet the stated requirement as described.
Which NIH institute and division aligned with this opportunity?
The funded science was expected to align with the mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), specifically the Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM).
What research areas or outcomes needed a strong connection to NIDDK/DEM priorities?
Projects needed a strong connection to metabolic disease, endocrine dysfunction, diabetes-related pathways, or closely related metabolic/endocrine outcomes in the context of HIV and its treatment.
What is the award mechanism for RFA-DK-14-023?
The award mechanism was the NIH R01, which supports investigator-initiated, multi-year research projects.
How much funding was estimated for this opportunity?
The announcement listed an estimated total funding level of about $2.5 million.
Was there an award ceiling?
Yes. The announcement included an award ceiling of $500,000.
Was cost sharing or matching required?
No. The opportunity stated there was no cost sharing or matching requirement.
What is the CFDA number associated with this program?
The program was cataloged under CFDA 93.847, "Diabetes, Digestive, and Kidney Diseases Extramural Research."
Who could apply for this funding opportunity?
Eligibility was broad and included many U.S.-based institutions and organizations, including:
- Public and private institutions of higher education
- Nonprofit organizations (501(c)(3) and non-501(c)(3))
- Small businesses
- For-profit organizations (other than small businesses)
- Government entities (state, county, city/township, special district governments, independent school districts, and public housing authorities)
Did the FOA explicitly include minority-serving and community-oriented institutions?
Yes. The FOA explicitly included several institution types and community-oriented entities, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, Asian American and Native American Pacific Islander-serving institutions, and faith-based or community-based organizations.
Were foreign institutions eligible to apply?
No. Foreign institutions were not eligible to apply based on the information provided.
Could a U.S. organization include a non-U.S. component?
No. Non-U.S. components of U.S. organizations were not eligible, as stated in the opportunity summary provided.
Are foreign components allowed in any form?
Yes, foreign components were allowed under NIH policy definitions, meaning certain international collaborations could be included when justified and compliant with NIH rules.
When was the opportunity posted and when was the application due?
The opportunity was posted on October 20, 2014, and the application due date was April 9, 2015.
Is this funding opportunity still open?
No. The announcement was later archived in May 2015, indicating it is no longer an active/open opportunity.
Which federal agency sponsored this funding opportunity?
The sponsoring agency was the National Institutes of Health (NIH).
Where was the full announcement hosted?
The full announcement was hosted through the NIH grants guide.
Who was the listed contact for technical issues with the announcement link or access?
For technical issues accessing or linking to the announcement, the contact point listed was the NIH Office of Extramural Research (OER) webmaster.
What made this FOA distinct from other types of NIH research announcements?
As described, a defining feature was the requirement for human-subject grounding (or direct use of human-derived materials/data from HIV-infected individuals), combined with a specific emphasis on metabolic and endocrine dysfunction in the context of HIV and ART, aligned with NIDDK/DEM priorities.
Did the FOA focus only on ART-related effects, or also on HIV itself and other factors?
It focused on multiple contributors, including HIV itself, relevant host factors or co-existing conditions, and antiretroviral therapy (ART) as potential drivers of metabolic/endocrine dysfunction.
Did the FOA include prevention and treatment research, or only mechanism studies?
In addition to mechanism-focused studies, the FOA emphasized research aimed at developing or testing strategies that could prevent, treat, or reverse metabolic and endocrine complications in people living with HIV.
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