Emerging Infections Sentinel Networks (EISN) Research | Apply Online

Opportunity Summary:

The Emerging Infections Sentinel Networks (EISN) Research opportunity (Funding Opportunity Number RFA CK 16 001) is a CDC-funded cooperative agreement designed to support and strengthen provider-based sentinel networks that can rapidly detect, track, and study emerging infectious diseases. The core idea is to maintain a structured set of participating clinical sites that routinely collect and share standardized infectious disease information, allowing public health partners to see trends early, compare patterns across locations, and respond faster when new threats appear. Rather than being a one-off study focused on a single pathogen, the program is meant to function as an ongoing surveillance and research platform that can pivot as new concerns arise.

The surveillance focus spans several high-priority categories of emerging infections. This includes drug-resistant infections, where timely data from frontline care settings can help identify shifting resistance patterns and inform treatment decisions and stewardship efforts. It also includes foodborne and waterborne illnesses, where early signal detection and rapid information exchange can support outbreak identification and investigation. Another major emphasis is vaccine-preventable or potentially vaccine-preventable diseases, where sentinel data can help assess disease burden, identify gaps in coverage, and detect changes in epidemiology that might suggest waning immunity, vaccine escape, or other evolving dynamics. A consistent theme across these areas is improving information exchange, meaning the network is expected not only to gather data, but also to move useful findings quickly to public health authorities and clinical partners.

On the research side, the provider-based sentinel networks are expected to do more than passive reporting. The stated objectives include conducting investigations of emerging infections and implementing studies that examine risk factors, help determine or refine practice guidelines, and evaluate outcomes. In practical terms, that points to applied, clinically grounded research that can link real-world patient characteristics, care processes, and clinical outcomes with infectious disease trends. The aim is to generate evidence that can be translated into improved clinical practice and public health action, such as identifying which patient groups are at highest risk, what diagnostic or treatment strategies work best in specific settings, and what outcomes are associated with different approaches.

A defining feature of this specific FOA is its emphasis on collecting infectious disease data from academically affiliated emergency departments. Emergency departments are often where emerging infections show up first, especially when patients are acutely ill or lack access to other care settings, and academic EDs may have the infrastructure and expertise to participate in more standardized data capture and collaborative studies. By targeting academically affiliated EDs, the program is positioning the network to capture high-value, real-time clinical information at a key point of entry into the healthcare system, supporting both surveillance and research that can inform immediate clinical decision-making and broader public health strategies.

Administratively, the opportunity is offered by HHS/CDC under the health activity category (CFDA 93.860) and uses a cooperative agreement funding instrument. A cooperative agreement typically indicates substantial involvement by the CDC in the funded work compared with a standard grant, often including collaborative planning, shared protocols, harmonized data elements, and coordinated priorities to ensure the network operates in a way that supports national surveillance and research needs. The posting and creation dates were October 23, 2015, and the application closing date was January 8, 2016. The listing indicates an expectation of a single award (ExpectedAwards: 1). The award ceiling is shown as 0 in the source data, which commonly signals that the ceiling was not specified in the summary fields and would normally be detailed in the full announcement or budget guidance. Eligibility is listed broadly as "Others (see text field entitled Additional Information on Eligibility for clarification)," suggesting that the full FOA would define the specific types of organizations permitted to apply, likely aligned with entities capable of running or coordinating sentinel networks and partnering with academically affiliated emergency departments.

Overall, this FOA is about building and operating a coordinated, provider-based sentinel network anchored in academic emergency departments to collect actionable infectious disease data, support surveillance across multiple emerging infection threats, and carry out targeted studies that clarify risk factors, guide clinical practice, and evaluate outcomes, with CDC working closely alongside the awardee through the cooperative agreement structure.

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