Opportunity Information: Apply for PA 15 325

  • The National Institutes of Health in the education health income security and social services sector is offering a public funding opportunity titled "End of Life and Palliative Needs of Adolescents and Young Adults (AYA) with Serious Illnesses (R21)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.313 NIH Office of Research on Womens Health 93.361 Nursing Research 93.393 Cancer Cause and Prevention Research 93.395 Cancer Treatment Research 93.399 Cancer Control 93.865 Child Health and Human Development Extramural Research.
  • This funding opportunity was created on Aug 7, 2015 and posted on Aug 7, 2015.
  • Applicants must submit their applications by Jan 7, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Independent school districts Private institutions of higher education County governments Special district governments For profit organizations other than small businesses City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Public housing authorities/Indian housing authorities.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

The End of Life and Palliative Needs of Adolescents and Young Adults (AYA) with Serious Illnesses (R21) opportunity (Funding Opportunity Number PA-15-325) is a National Institutes of Health (NIH) research grant aimed at building knowledge and testing ideas that improve end-of-life and palliative care for adolescents and young adults ages 12 to 24. The core goal is to support studies that better capture how seriously ill AYA think and feel about their care, what they want and need as illness progresses, and how they make decisions in the context of advanced disease. A major emphasis is on the fact that AYA face distinct developmental, emotional, social, and family circumstances compared with younger children or older adults, so traditional palliative approaches may not fully fit their realities.

This FOA encourages research that explores the unique perspectives, needs, wishes, and decision-making processes of AYA with serious, advanced illnesses. That includes work focused on communication preferences, shared decision making with caregivers and clinicians, and how AYA weigh autonomy, family involvement, and quality of life when facing complex medical choices. It also highlights the importance of studying and developing end-of-life/palliative care (EOLPC) models specifically designed to support the full spectrum of AYA needs, not just symptom control. The FOA explicitly points to models that address physical comfort as well as psychological wellbeing, spiritual concerns, and social factors that affect both patients and the people around them, including families and caregivers.

From an administrative standpoint, this is a discretionary NIH grant using the R21 mechanism, which is commonly used for exploratory and developmental research. The listed award ceiling is $200,000, and there is no cost sharing or matching requirement. The opportunity was posted and created on August 7, 2015, with an original and current closing date of January 7, 2019, and it was archived on February 7, 2019, meaning it is no longer open for new applications under that specific announcement, though similar NIH funding opportunities may exist.

Eligibility is broad and includes many types of organizations that commonly conduct health research. Eligible applicants include public and private institutions of higher education, nonprofits (including 501(c)(3) organizations and nonprofits without 501(c)(3) status), for-profit organizations (including small businesses and other for-profits), and multiple levels of government such as state, county, city/township, special district governments, independent school districts, and public housing authorities/Indian housing authorities. Tribal organizations and tribal governments are eligible, including federally recognized tribes and other tribal entities. The eligibility list also specifically includes a wide range of designated institutions and community-based entities such as Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). Faith-based and community-based organizations, U.S. territories or possessions, regional organizations, and even non-U.S. entities (foreign organizations) are also included, reflecting NIH interest in diverse settings and perspectives relevant to AYA serious illness and palliative care.

The program aligns with multiple health-related federal funding areas and is associated with several CFDA numbers reflecting NIH institutes and priorities connected to womens health, nursing research, cancer research across prevention, treatment, and control, and child health and human development research (including CFDA 93.313, 93.361, 93.393, 93.395, 93.399, and 93.865). In practice, that mix signals that the topic cuts across oncology and non-oncology serious illnesses and encourages multidisciplinary teams, such as clinicians, nurses, psychologists, social workers, spiritual care providers, health services researchers, and others who can rigorously study and improve palliative models for this age group.

For anyone trying to locate the original announcement details, the FOA link is: http://grants.nih.gov/grants/guide/pa-files/PA-15-325.html. For technical issues accessing the announcement or linking problems, the contact provided is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

FAQs: The End of Life and Palliative Needs of Adolescents and Young Adults (AYA) with Serious Illnesses (R21) (PA-15-325)

What is PA-15-325?

PA-15-325 is a National Institutes of Health (NIH) Funding Opportunity Announcement (FOA) titled "The End of Life and Palliative Needs of Adolescents and Young Adults (AYA) with Serious Illnesses (R21)." It supports research designed to build knowledge and test ideas to improve end-of-life and palliative care for adolescents and young adults.

What is the main purpose of this grant opportunity?

The core goal is to support studies that better capture how seriously ill adolescents and young adults think and feel about their care, what they want and need as illness progresses, and how they make decisions in the context of advanced disease.

Who is the focus population for this FOA?

The focus is on adolescents and young adults (AYA) ages 12 to 24 who have serious, advanced illnesses and may have end-of-life and palliative care needs.

Why does NIH emphasize AYA-specific end-of-life and palliative care?

The FOA highlights that AYA have distinct developmental, emotional, social, and family circumstances compared with younger children or older adults. Because of this, traditional palliative approaches may not fully fit the realities of adolescents and young adults.

What types of research does this FOA encourage?

This FOA encourages exploratory and developmental research that examines the unique perspectives, needs, wishes, and decision-making processes of AYA with serious illness, including how their preferences may change as illness progresses.

Does the FOA include research on communication and decision making?

Yes. It explicitly encourages work focused on communication preferences, shared decision making with caregivers and clinicians, and how AYA weigh autonomy, family involvement, and quality of life when facing complex medical choices.

Is the focus only on symptom control?

No. The FOA emphasizes end-of-life and palliative care models that support the full spectrum of AYA needs, not just symptom management.

What domains of care are highlighted beyond physical comfort?

In addition to physical comfort, the FOA points to psychological wellbeing, spiritual concerns, and social factors that affect both patients and the people around them, including families and caregivers.

What funding mechanism is used for this opportunity?

This opportunity uses the NIH R21 mechanism, which is commonly used for exploratory and developmental research.

What is the award ceiling for PA-15-325?

The listed award ceiling is $200,000.

Is there a cost sharing or matching requirement?

No. The FOA specifies that there is no cost sharing or matching requirement.

Is this FOA still open for new applications?

No. The opportunity was archived on February 7, 2019, and the original/current closing date listed is January 7, 2019. That means it is no longer open for new applications under this specific announcement.

If the FOA is archived, can similar funding opportunities still exist?

Yes. While PA-15-325 itself is no longer open, the information provided notes that similar NIH funding opportunities may exist.

When was this funding opportunity posted?

The FOA was posted and created on August 7, 2015.

Who can apply for this NIH grant (based on the eligibility list provided)?

Eligibility is broad and includes public and private institutions of higher education; nonprofits (including 501(c)(3) organizations and nonprofits without 501(c)(3) status); for-profit organizations (including small businesses and other for-profits); and multiple levels of government (such as state, county, city/township, special district governments, independent school districts, and public housing authorities/Indian housing authorities).

Are tribal governments and tribal organizations eligible?

Yes. Tribal governments (federally recognized and other tribal entities) and tribal organizations are listed as eligible.

Are minority-serving institutions specifically included in eligibility?

Yes. The eligibility list specifically includes institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).

Can faith-based or community-based organizations apply?

Yes. Faith-based and community-based organizations are included in the eligibility list.

Are U.S. territories or possessions eligible to apply?

Yes. U.S. territories or possessions are included in the eligibility list.

Are non-U.S. (foreign) organizations eligible?

Yes. The eligibility list includes non-U.S. entities (foreign organizations), reflecting an interest in diverse settings and perspectives related to AYA serious illness and palliative care.

What fields or disciplines are relevant to this FOA?

The FOA suggests the topic is multidisciplinary and may involve clinicians, nurses, psychologists, social workers, spiritual care providers, health services researchers, and others who can rigorously study and improve palliative models for adolescents and young adults.

Is the FOA limited to cancer (oncology) populations?

No. The information provided indicates the topic cuts across oncology and non-oncology serious illnesses, even though it aligns with several NIH priorities that include cancer-related areas.

Which CFDA numbers are associated with this opportunity?

The opportunity is associated with several CFDA numbers: 93.313, 93.361, 93.393, 93.395, 93.399, and 93.865.

Where can I find the original FOA announcement?

The FOA link provided is: http://grants.nih.gov/grants/guide/pa-files/PA-15-325.html

Who should be contacted for technical issues accessing the announcement link?

For technical issues accessing the announcement or for linking problems, the contact provided is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

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