Opportunity Information: Apply for CDC RFA CE16 1608
Apply for CDC RFA CE16 1608
- The HHS-CDC-NCIPC in the health sector is offering a public funding opportunity titled "Enhanced State Surveillance of Opioid-Involved Morbidity and Mortality" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.136.
- This funding opportunity was created on Apr 25, 2016 and posted on Apr 25, 2016.
- Applicants must submit their applications by Jun 27, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $775,000.00 in funding.
- The number of recipients for this funding is limited to 11 candidate(s).
- Eligible applicants include: State governments.
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Opportunity Summary:
The CDC cooperative agreement opportunity titled Enhanced State Surveillance of Opioid-Involved Morbidity and Mortality (CDC RFA CE16-1608) was created to help certain state governments speed up and strengthen overdose surveillance during a period when opioid deaths were rising quickly and changing in character. The problem statement is straightforward: opioid-involved overdose deaths had quadrupled since 1999, reaching 28,647 deaths in 2014, and the epidemic was being driven by two connected trends. One was a long-running rise in deaths involving prescription opioid pain relievers, and the other was a newer surge in heroin deaths that research linked back to prescription opioid misuse (with most new heroin users reporting prior misuse of prescription opioids). At the same time, the opioid supply and the drugs involved in fatal overdoses were shifting rapidly, including sharp increases in heroin and commonly prescribed opioids from 2013 to 2014, and a multi-state surge in deaths tied to illicitly manufactured fentanyl. Existing surveillance systems often produced data with delays longer than a year, which limited the ability of public health agencies and partners to respond quickly. The FOA also emphasizes that overdose patterns vary substantially by county and region, so states need more timely, more local data on both outcomes and risk factors to target interventions effectively.
The overall goal of the funding is to improve the timeliness and usefulness of state-level surveillance for both nonfatal and fatal opioid overdoses, especially in states with high overdose death rates in 2014 or states experiencing rapidly increasing overdose death rates between 2012 and 2014. In addition to producing faster counts and trends, the grant prioritizes better reporting of circumstances and risk factors associated with fatal overdoses, so prevention efforts can focus on actionable drivers rather than only on totals. Awardees are also expected to share their surveillance data with CDC to support enhanced multi-state monitoring of opioid-involved overdoses, creating a more coherent national picture across participating jurisdictions.
The work is organized around three main required activities. First, states must increase the timeliness of nonfatal overdose reporting by producing quarterly reports on rates of emergency department visits and/or emergency medical services responses to suspected overdoses. These reports must cover suspected overdoses involving any drug, any opioid (including prescription opioids, heroin, and illicitly manufactured fentanyl), and/or heroin, and they must be produced within three months of the overdose events. The FOA expects jurisdictions to build on existing rapid ED and EMS data collection platforms rather than creating entirely new systems, and it acknowledges that complete statewide capture may not be immediately feasible. Even so, applicants are required to calculate the selected indicators using at least 50 percent of ED visits or EMS transports, establishing a minimum standard for coverage while still enabling faster reporting.
Second, states must increase the timeliness of fatal overdose surveillance and the capture of associated risk factors by abstracting information within eight months of death. This abstraction is to be completed using the National Violent Death Reporting System (NVDRS) web-based data entry system, drawing from both death certificates and medical examiner/coroner reports. Jurisdictions can choose one of two approaches for the death abstraction scope: include all opioid-involved deaths statewide, or focus on a subset of counties as long as those counties accounted for at least 75 percent of the unintentional or undetermined drug overdose deaths occurring in 2014. Importantly, CDC requires use of a standardized set of variables defined by CDC and entered via the NVDRS web system, which is intended to improve consistency and comparability across states. The FOA also clarifies that a state does not need to already be an NVDRS participant to carry out this requirement, lowering a key administrative barrier to participation.
Third, awardees must disseminate their surveillance findings to the people and organizations positioned to prevent overdoses. Each funded state is expected to create and implement a dissemination plan that uses multiple strategies to share results with key stakeholders, which can include public health leadership, local health departments, emergency response systems, healthcare systems, substance use treatment providers, policymakers, and community coalitions. The underlying idea is that faster data on ED/EMS overdose events and faster, richer information on overdose deaths and risk factors should translate into quicker, better-targeted prevention and response actions, whether that means identifying emerging fentanyl hotspots, detecting heroin spikes in particular regions, or tailoring interventions to the circumstances most frequently documented in fatal cases.
In terms of basic grant mechanics, this was a discretionary CDC funding opportunity administered by HHS/CDC/NCIPC and issued as a cooperative agreement, signaling substantial federal involvement and ongoing collaboration rather than a hands-off grant. Eligibility was limited to state governments. The opportunity listed an award ceiling of $775,000, anticipated 11 awards, and carried a closing date of June 27, 2016 (original and current). The funding is cataloged under CFDA 93.136. Overall, the program is best understood as an effort to shorten the time between overdose events and actionable intelligence, while improving the depth and consistency of fatal overdose investigations and ensuring that findings reach the stakeholders who can act on them.
Frequently Asked Questions (FAQs)
What is the name of this CDC funding opportunity?
The opportunity is titled Enhanced State Surveillance of Opioid-Involved Morbidity and Mortality and is identified as CDC RFA CE16-1608.
What is the main purpose of this cooperative agreement?
The purpose is to help certain state governments speed up and strengthen overdose surveillance so public health agencies can respond more quickly to rapidly changing opioid overdose patterns. The focus is on improving both nonfatal overdose reporting (ED/EMS data) and fatal overdose surveillance (including circumstances and risk factors), and sharing the resulting surveillance data with CDC to support enhanced multi-state monitoring.
Why did CDC create this program?
The program was created in response to a fast-changing opioid overdose epidemic. Opioid-involved overdose deaths had quadrupled since 1999, reaching 28,647 deaths in 2014. The epidemic was driven by two linked trends: a long-term rise in deaths involving prescription opioid pain relievers and a newer surge in heroin deaths associated with prior misuse of prescription opioids. At the same time, the opioid supply and drugs implicated in overdoses were shifting quickly, including increases in heroin and commonly prescribed opioids (2013-2014) and a multi-state surge tied to illicitly manufactured fentanyl. Many existing surveillance systems produced data with delays of more than a year, limiting timely action.
What does CDC mean by improving the "timeliness and usefulness" of surveillance?
"Timeliness" refers to producing overdose surveillance outputs quickly enough to support near-real-time decision-making rather than waiting a year or more. "Usefulness" refers to producing information that is actionable, including local patterns and, for fatal overdoses, richer detail on circumstances and risk factors rather than only total counts.
Who is eligible to apply?
Eligibility is limited to state governments.
What type of funding mechanism is used?
This is a CDC cooperative agreement, which indicates substantial federal involvement and ongoing collaboration with awardees, rather than a hands-off grant.
Which CDC/HHS office administered the opportunity?
The opportunity was administered by HHS/CDC/NCIPC.
What is the CFDA number for this program?
The program is cataloged under CFDA 93.136.
How many awards were anticipated and what was the award ceiling?
The opportunity anticipated 11 awards and listed an award ceiling of $775,000.
What was the closing date for applications?
The closing date listed was June 27, 2016 (original and current).
Which states were the intended targets for this funding?
The overall goal prioritized states with high overdose death rates in 2014 or states experiencing rapidly increasing overdose death rates between 2012 and 2014.
Why does the FOA emphasize county and regional variation?
The FOA notes that overdose patterns vary substantially by county and region. That variation means states need more timely, more local data on both outcomes and risk factors to target prevention and response efforts effectively.
What are the three main required activities under this cooperative agreement?
The work is organized around three required activities:
- Increase the timeliness of nonfatal overdose reporting using ED and/or EMS data and produce quarterly reports within a defined timeframe.
- Increase the timeliness of fatal overdose surveillance and capture associated risk factors by abstracting information within a defined timeframe using the NVDRS web-based data entry system.
- Disseminate findings through a plan that uses multiple strategies to reach stakeholders positioned to prevent overdoses.
What is required for nonfatal overdose surveillance reporting?
States must improve the timeliness of nonfatal overdose reporting by producing quarterly reports on rates of emergency department (ED) visits and/or emergency medical services (EMS) responses to suspected overdoses.
How quickly must the nonfatal overdose quarterly reports be produced?
The quarterly reports must be produced within three months of the overdose events.
What overdose categories must be included in the nonfatal reporting?
The quarterly reporting must cover suspected overdoses involving:
- Any drug, and/or
- Any opioid (including prescription opioids, heroin, and illicitly manufactured fentanyl), and/or
- Heroin
Does the FOA require states to build new ED/EMS data systems from scratch?
No. The FOA expects jurisdictions to build on existing rapid ED and EMS data collection platforms rather than creating entirely new systems.
Is complete statewide ED/EMS capture required immediately?
No. The FOA acknowledges that complete statewide capture may not be immediately feasible.
Is there a minimum coverage requirement for ED or EMS data used to calculate indicators?
Yes. Applicants are required to calculate the selected indicators using at least 50 percent of ED visits or EMS transports. This establishes a minimum standard for coverage while still enabling faster reporting.
What is required for fatal overdose surveillance under this program?
States must increase the timeliness of fatal overdose surveillance and improve capture of circumstances and risk factors by abstracting information within eight months of death. The abstraction must be completed using the NVDRS web-based data entry system and must draw from death certificates and medical examiner/coroner reports.
How quickly must fatal overdose information be abstracted?
Fatal overdose abstraction is required to be completed within eight months of death.
Which data sources are used for the fatal overdose abstraction?
The abstraction draws from death certificates and medical examiner/coroner reports, and the information is entered into the NVDRS web-based data entry system.
What system must be used to enter fatal overdose abstraction data?
CDC requires use of the National Violent Death Reporting System (NVDRS) web-based data entry system for entering the standardized abstraction variables.
Does a state need to already be an NVDRS participant to apply or meet the fatal overdose requirement?
No. The FOA clarifies that a state does not need to already be an NVDRS participant to carry out this requirement.
How much of the state must be covered for fatal overdose abstraction?
Jurisdictions can choose one of two approaches:
- Include all opioid-involved deaths statewide, or
- Focus on a subset of counties, as long as those counties accounted for at least 75 percent of the unintentional or undetermined drug overdose deaths occurring in 2014.
Are there standardized variables required for fatal overdose abstraction?
Yes. CDC requires using a standardized set of variables defined by CDC and entering them via the NVDRS web system. This is intended to improve consistency and comparability across participating states.
What is the dissemination requirement?
Each funded state is expected to create and implement a dissemination plan that uses multiple strategies to share surveillance results with stakeholders positioned to prevent overdoses.
Who are examples of stakeholders that should receive dissemination outputs?
The FOA lists stakeholders such as public health leadership, local health departments, emergency response systems, healthcare systems, substance use treatment providers, policymakers, and community coalitions.
What kinds of public health actions is this program meant to support?
The program is designed to shorten the time between overdose events and actionable intelligence so states can respond faster and more precisely, such as by identifying emerging fentanyl hotspots, detecting heroin spikes in specific regions, and tailoring interventions based on the circumstances and risk factors most frequently documented in fatal overdoses.
What does it mean that awardees are expected to share surveillance data with CDC?
Awardees are expected to share their surveillance data with CDC to support enhanced multi-state monitoring of opioid-involved overdoses, helping create a more coherent picture across participating jurisdictions.
What is the overall outcome CDC is trying to achieve with this opportunity?
Overall, CDC is trying to improve state capacity to deliver faster, more local, and more informative overdose surveillance for both nonfatal and fatal overdoses, and to ensure those findings are actively disseminated to stakeholders who can use them to prevent overdoses.
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