Opportunity Information: Apply for PA 12 104
Apply for PA 12 104
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Enhancing Cellular Immunity in the Female Reproductive Tract (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Oct 19, 2012 and posted on Feb 14, 2012.
- Applicants must submit their applications by Jan 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Native American tribal governments (Federally recognized) County governments City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Independent school districts Small businesses For profit organizations other than small businesses State governments Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH Funding Opportunity Announcement PA 12-104, titled "Enhancing Cellular Immunity in the Female Reproductive Tract (R01)," is a discretionary grant program designed to push forward basic and mechanistic immunology research focused on the female reproductive tract (FRT). The central scientific aim is to uncover how effective, antigen-specific CD8 memory T cells are induced in the FRT and, just as importantly, how those memory responses are maintained over time in that tissue environment. The bigger picture behind the FOA is to build a stronger mechanistic foundation for future vaccine strategies that could generate durable, protective T-lymphocyte immunity at this mucosal site, with particular relevance to preventing infection by HIV and other mucosal pathogens that can affect the reproductive tract.
A key feature of this opportunity is that it emphasizes discovery and mechanism rather than product testing. In practical terms, the FOA is looking for studies that explain the rules of tissue-specific cellular immunity in the FRT: what signals, cell types, tissue niches, hormonal influences, antigen exposure patterns, trafficking cues, and local microenvironmental factors shape the generation of CD8 memory and its persistence. The intended outcome is knowledge that can later be translated into vaccine design principles, such as identifying which pathways or local conditions are necessary to create long-lived, functional, pathogen-specific CD8 memory cells in the FRT. At the same time, the announcement is explicit about what it is not meant to fund: it is not intended to support studies that primarily evaluate mucosal vaccines or therapeutic interventions, and it is not meant for research that is primarily pathogen-centered. In other words, applicants are expected to focus on host immune mechanisms and tissue immunology rather than running vaccine efficacy-style experiments or building an application mainly around a specific infectious agent.
This FOA uses the NIH R01 mechanism, which typically supports mature, hypothesis-driven projects with enough scope to address substantial biological questions through multiple aims and complementary approaches. The activity falls under health-related research, and it is associated with CFDA numbers 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research), reflecting its placement within NIH’s infectious disease and immunology research priorities. There is no cost sharing or matching requirement, which means applicants are not expected to contribute non-federal funds as a condition of the award.
Eligibility is broad and includes a wide range of domestic and international organizations. Eligible applicants include public and private institutions of higher education, public and state-controlled institutions of higher education, nonprofit organizations with or without 501(c)(3) status (excluding institutions of higher education in those categories), for-profit organizations (including small businesses and other for-profit entities), and multiple levels of government such as city/township, county, state, special district governments, and eligible federal agencies. The eligibility list also specifically includes tribal governments (federally recognized and other than federally recognized) and tribal organizations, tribally controlled colleges and universities, Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), and faith-based or community-based organizations. Importantly, non-U.S. entities (foreign institutions) are eligible to apply, non-U.S. components of U.S. organizations may apply, and foreign components are permitted under NIH policy, which opens the door for internationally based immunology and mucosal biology expertise when it strengthens the proposed science.
From an administrative standpoint, the opportunity was posted on February 14, 2012, with the FOA carrying an archive date of February 7, 2013. The source data indicates an original closing date of January 7, 2015, while also listing a current closing date of January 7, 2013, which suggests the solicitation information may have been updated or archived in a way that affects submission timing; applicants would typically confirm applicable due dates and receipt cycles directly in the full FOA text and via NIH’s standard submission systems and deadlines.
The sponsoring agency is the National Institutes of Health, and the full announcement was made available through the NIH grants guide at the provided link (http://grants.nih.gov/grants/guide/pa-files/PA-12-104.html). For access issues or technical problems related to the electronic announcement, the contact point listed is the NIH Office of Extramural Research webmaster (FBOWebmaster@OD.NIH.GOV), which is geared toward resolving document access and linking problems rather than scientific or programmatic questions.
Overall, this grant opportunity is best understood as a targeted call for rigorous, mechanistic studies that explain how the FRT can be engineered, through informed vaccine design in the future, to support strong and lasting CD8 memory T cell immunity. The emphasis is on foundational immunological understanding of tissue-resident or tissue-associated memory responses in the reproductive mucosa, producing insights that later vaccine developers can use, rather than directly testing vaccine candidates or focusing mainly on pathogen biology.
FAQs: NIH PA-12-104 - Enhancing Cellular Immunity in the Female Reproductive Tract (R01)
What is the funding opportunity and what does it support?
This is an NIH Funding Opportunity Announcement (FOA) titled "Enhancing Cellular Immunity in the Female Reproductive Tract (R01)" (PA-12-104). It supports basic and mechanistic immunology research focused on the female reproductive tract (FRT), with an emphasis on how antigen-specific CD8 memory T cell responses are generated and maintained over time in that tissue environment.
What is the main scientific goal of PA-12-104?
The central goal is to uncover how effective, antigen-specific CD8 memory T cells are induced in the female reproductive tract and how those memory responses persist long-term in that mucosal tissue. The broader intent is to strengthen the mechanistic foundation that can later inform vaccine design strategies aimed at durable protective T-lymphocyte immunity in the FRT.
Why is the female reproductive tract (FRT) the focus?
The FOA targets the FRT as a key mucosal site where durable cellular immunity could be important for preventing infection by HIV and other mucosal pathogens that affect the reproductive tract. The emphasis is on understanding tissue-specific rules of immunity in this environment.
Is this FOA focused on vaccine testing or vaccine efficacy studies?
No. A defining feature of this opportunity is its emphasis on discovery and mechanism rather than product testing. It is not intended to support studies that primarily evaluate mucosal vaccines or therapeutic interventions.
Is pathogen-centered research appropriate for this opportunity?
The announcement states it is not meant for research that is primarily pathogen-centered. Applicants are expected to focus on host immune mechanisms and tissue immunology rather than building the application mainly around a specific infectious agent.
What kinds of research questions does NIH want addressed in this FOA?
The FOA is looking for studies that explain the "rules" of tissue-specific cellular immunity in the FRT. Examples of areas of interest mentioned include signals, cell types, tissue niches, hormonal influences, antigen exposure patterns, trafficking cues, and local microenvironmental factors that shape CD8 memory generation and persistence in the FRT.
What is the intended outcome or deliverable from funded projects?
The intended outcome is mechanistic knowledge that can later be translated into vaccine design principles, such as identifying pathways or local conditions needed to create long-lived, functional, pathogen-specific CD8 memory cells in the FRT. The FOA is aimed at foundational understanding rather than direct development or evaluation of interventions.
What funding mechanism does this FOA use?
This FOA uses the NIH R01 mechanism, which typically supports mature, hypothesis-driven projects with enough scope to address substantial biological questions through multiple aims and complementary approaches.
What is the sponsoring agency?
The sponsoring agency is the National Institutes of Health (NIH).
What are the CFDA numbers associated with this opportunity?
The opportunity is associated with CFDA 93.855 (Allergy and Infectious Diseases Research) and CFDA 93.856 (Microbiology and Infectious Diseases Research).
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement, meaning applicants are not expected to contribute non-federal funds as a condition of the award.
Who is eligible to apply?
Eligibility is broad. The FOA includes (among others) public and private institutions of higher education, public/state-controlled institutions of higher education, nonprofit organizations (with or without 501(c)(3) status, excluding institutions of higher education in those nonprofit categories), for-profit organizations (including small businesses), and multiple levels of government (city/township, county, state, special district governments, and eligible federal agencies).
Are tribal governments and tribal organizations eligible?
Yes. The eligibility list specifically includes tribal governments (federally recognized and other than federally recognized) and tribal organizations, as well as tribally controlled colleges and universities.
Are minority-serving institutions and faith-based/community-based organizations eligible?
Yes. The eligibility list includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), and faith-based or community-based organizations.
Can non-U.S. (foreign) organizations apply?
Yes. The FOA states that non-U.S. entities (foreign institutions) are eligible to apply. It also allows non-U.S. components of U.S. organizations to apply, and foreign components are permitted under NIH policy.
What are the key dates listed for this FOA?
The opportunity was posted on February 14, 2012, and the FOA has an archive date of February 7, 2013. The source information also shows an original closing date of January 7, 2015, while listing a current closing date of January 7, 2013. Because of this mismatch, applicants would typically confirm the applicable due dates and receipt cycles in the full FOA text and through NIH submission systems and deadlines.
Where can I find the full FOA text?
The full announcement is available through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PA-12-104.html
Who should be contacted for technical problems accessing the announcement?
For access issues or technical problems related to the electronic announcement, the listed contact is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV. This contact is described as support for document access and linking issues rather than scientific or programmatic questions.
In simple terms, what kind of application fits this FOA best?
An application that fits best is one centered on rigorous, mechanistic studies of CD8 memory T cell induction and maintenance in the female reproductive tract, focused on host immune mechanisms and tissue immunology, and aimed at generating insights that can later guide vaccine design rather than directly testing vaccine candidates or therapeutic interventions.
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