Opportunity Information: Apply for RFA RM 12 009
Apply for RFA RM 12 009
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Enhancing GTEx with molecular analyses of stored biospecimens (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Nov 16, 2012 and posted on Nov 16, 2012.
- Applicants must submit their applications by Mar 28, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Special district governments Native American tribal governments (Federally recognized) State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education City or township governments Public and State controlled institutions of higher education Independent school districts For profit organizations other than small businesses Small businesses Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH funding opportunity "Enhancing GTEx with molecular analyses of stored biospecimens (U01)" (Funding Opportunity Number RFA-RM-12-009) is a discretionary grant program issued by the National Institutes of Health to expand the scientific value of the Genotype-Tissue Expression (GTEx) project by funding new molecular analyses on stored GTEx biospecimens. The central purpose is to generate additional molecular phenotype data from existing GTEx samples, enabling researchers to ask new, compelling biological questions and to deepen understanding of how genetic variation influences molecular regulation across a wide range of human tissues. Rather than collecting new samples, the opportunity focuses on extracting more knowledge from the unique multi-tissue resource GTEx has already created.
This announcement uses the U01 mechanism, meaning awards are made as cooperative agreements. In practice, that signals an active partnership model where NIH expects substantial involvement in the project, often including coordination around data standards, assay choices, quality control expectations, and integration of resulting datasets into the broader GTEx ecosystem. The emphasis is on producing high-value molecular datasets that complement and strengthen what GTEx already provides, with a clear preference for work that leverages GTEx's defining features, especially the breadth of tissue types from the same donors and the ability to connect genetic variation to tissue-specific molecular outcomes.
The scientific scope is centered on "molecular analyses" and "molecular phenotypes" derived from stored biospecimens. While the brief description does not list specific assay types, the intent is to encourage applicants to propose molecular measurements that meaningfully extend the resource, such as new omics layers or refined molecular readouts that can be linked to genotype and tissue context. The most competitive projects would be expected to articulate why the proposed molecular phenotypes are additive to existing GTEx datasets, how they enable new discovery, and how they will be generated and analyzed in a way that is robust, comparable, and reusable by the broader research community.
From an administrative standpoint, the opportunity is categorized under Health and carries CFDA 93.310 (Trans-NIH Research Support). There is no cost sharing or matching requirement. The announcement was posted and created on November 16, 2012, with an original and current closing date of March 28, 2013, and an archive date of April 28, 2013. These dates indicate the solicitation is historical/archived rather than currently open, but the content still provides a clear picture of NIH's priorities at the time for enhancing GTEx through additional molecular profiling of banked specimens.
Eligibility is broad and inclusive, spanning many organization types. Eligible applicants include various levels of government (state, county, city/township, special district), public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (with or without 501(c)(3) status, other than institutions of higher education), independent school districts, public housing authorities/Indian housing authorities, for-profit organizations other than small businesses, and small businesses. The eligibility section also explicitly includes a wide range of mission-driven and designated institution types such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and AANAPISI institutions, as well as faith-based or community-based organizations and eligible federal agencies. Importantly, non-U.S. entities are eligible: foreign organizations and foreign institutions may apply, non-U.S. components of U.S. organizations are eligible, and foreign components (as defined by NIH policy) are allowed. This broad eligibility underscores that NIH was seeking the best-qualified teams to generate impactful molecular data from GTEx materials, regardless of geography, provided NIH policy requirements are met.
The official announcement link is provided through the NIH grants guide at http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-12-009.html. For access or linking issues, the listed contact is the NIH Office of Extramural Research webmaster (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The funding opportunity is titled "Enhancing GTEx with molecular analyses of stored biospecimens (U01)."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is RFA-RM-12-009.
Which agency is offering this grant?
This is a discretionary grant program issued by the National Institutes of Health (NIH).
What is the main purpose of this opportunity?
The purpose is to expand the scientific value of the Genotype-Tissue Expression (GTEx) project by funding new molecular analyses on stored GTEx biospecimens, generating additional molecular phenotype data from existing GTEx samples.
Is this opportunity about collecting new biospecimens?
No. The focus is on generating additional data from stored (already collected) GTEx biospecimens, rather than collecting new samples.
What kind of work is NIH trying to fund under this announcement?
NIH is seeking projects that perform molecular analyses on stored GTEx biospecimens to produce new molecular phenotypes that complement existing GTEx datasets and increase the resource's value for the broader research community.
What are "molecular phenotypes" in the context of this opportunity?
In this context, molecular phenotypes are molecular measurements derived from stored biospecimens (for example, additional molecular readouts or new omics layers) that can be linked to genotype and tissue context to enable new biological questions and discoveries.
Does the description specify which assays or omics platforms must be used?
No. The information provided does not list specific assay types. It indicates applicants are expected to propose molecular measurements that meaningfully extend GTEx and are robust, comparable, and reusable by the broader community.
What makes a project competitive based on the information provided?
Based on the description, competitive projects would explain why the proposed molecular phenotypes add value beyond existing GTEx datasets, how they enable new discovery, and how the data will be generated and analyzed with strong robustness, comparability, and reusability for integration into the broader GTEx ecosystem.
Why is GTEx a strong platform for this kind of work?
The opportunity emphasizes leveraging GTEx's defining features, especially the breadth of tissue types collected from the same donors and the ability to connect genetic variation to tissue-specific molecular outcomes.
What award mechanism is being used?
This announcement uses the U01 mechanism.
What does it mean that this is a U01 cooperative agreement?
A U01 is a cooperative agreement, which signals an active partnership model where NIH expects substantial involvement. The description notes this often includes coordination around data standards, assay choices, quality control expectations, and integration of resulting datasets into the broader GTEx ecosystem.
What is the program category and CFDA number?
The opportunity is categorized under Health and lists CFDA 93.310 (Trans-NIH Research Support).
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
Is this funding opportunity currently open?
No. The dates provided indicate it is historical/archived: posted/created November 16, 2012; closing date March 28, 2013; archive date April 28, 2013.
Who is eligible to apply?
Eligibility is broad. It includes multiple levels of government (state, county, city/township, special district), public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (with or without 501(c)(3) status, other than institutions of higher education), independent school districts, public housing authorities/Indian housing authorities, for-profit organizations other than small businesses, and small businesses.
Are specific institution types (such as HBCUs or tribal colleges) included as eligible applicants?
Yes. The eligibility section explicitly includes HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and AANAPISI institutions, among others.
Are faith-based or community-based organizations eligible?
Yes. Faith-based and community-based organizations are explicitly listed as eligible.
Are federal agencies eligible to apply?
Yes. The eligibility section includes eligible federal agencies.
Can non-U.S. organizations apply?
Yes. Foreign organizations and foreign institutions may apply, non-U.S. components of U.S. organizations are eligible, and foreign components (as defined by NIH policy) are allowed.
Where can applicants find the official announcement?
The official announcement is available through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-12-009.html
Who should be contacted if there are access or linking issues with the announcement page?
The listed contact for access or linking issues is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
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