Opportunity Information: Apply for PAR 08 139

  • The National Institutes of Health in the education environment food and nutrition health income security and social services sector is offering a public funding opportunity titled "Enhancing Zebrafish Research with Research Tools and Techniques (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.121 Oral Diseases and Disorders Research 93.172 Human Genome Research 93.173 Research Related to Deafness and Communication Disorders 93.233 National Center on Sleep Disorders Research 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.396 Cancer Biology Research 93.837 Cardiovascular Diseases Research 93.839 Blood Diseases and Resources Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.859 Biomedical Research and Research Training 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research 93.867 Vision Research.
  • This funding opportunity was created on Dec 5, 2008 and posted on Apr 9, 2008.
  • Applicants must submit their applications by Sep 17, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: State governments Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses County governments Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Small businesses Special district governments Private institutions of higher education City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

The NIH funding opportunity PAR 08-139, titled "Enhancing Zebrafish Research with Research Tools and Techniques (R01)," supports investigator-initiated research projects that strengthen and expand the zebrafish (Danio rerio) as a widely used vertebrate model for biomedical and behavioral science. The central aim is not simply to run zebrafish experiments, but to create or significantly improve broadly useful research tools and techniques that the larger zebrafish community can adopt. In practice, the FOA is looking for enabling technologies that make it easier to detect, measure, and interpret genes, pathways, and phenotypes in zebrafish across a wide range of biological and disease areas.

Scientifically, the opportunity is geared toward tool and method development that advances studies in core domains where zebrafish are especially powerful: development and aging, organ formation and function, neural processes, behavior and sensory processing, physiological regulation, and disease mechanisms. Competitive applications would typically propose approaches that improve how researchers identify and characterize genetic and molecular pathways, connect those pathways to observable traits, and measure phenotypes with higher precision, throughput, or biological relevance. The announcement emphasizes community priority, meaning the most responsive projects are those that address widely recognized bottlenecks or unmet needs in zebrafish research rather than narrowly tailored tools for a single lab.

This FOA is part of a broader NIH initiative organized through the Trans-NIH Zebrafish Coordinating Committee (TZCC), co-chaired by NICHD and NIDDK, which signals cross-institute interest in zebrafish resource and technology development. The wide set of CFDA program numbers associated with the announcement (spanning environmental health, genomics, deafness and communication disorders, sleep, mental health, alcohol and drug abuse, cancer biology, cardiovascular and blood diseases, diabetes and kidney disease, neuroscience and neurological disorders, child health and development, aging, and vision research) reinforces that NIH intends these tools to have broad relevance across many disease and basic science missions.

The mechanism of support is the NIH Research Project Grant (R01), which generally funds well-developed research plans that can produce a substantial, validated deliverable (in this case, a tool, technique, or platform) within the scope and timeline typical of an R01 project. Awards under this opportunity are contingent on the availability of funds and on NIH receiving a sufficient number of highly meritorious applications, and the announcement does not guarantee a specific number of awards.

In terms of who can apply, eligibility is broad and includes many types of U.S. and non-U.S. organizations: public and private institutions of higher education, nonprofits (including both 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), and various government entities (state, county, city/township, special district, and tribal governments). The eligibility language also explicitly includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities, Tribally Controlled Colleges and Universities, U.S. territories and possessions, and foreign organizations. There is no cost sharing or matching requirement.

Administratively, the opportunity was posted April 9, 2008, with a closing date of September 17, 2010, and it was archived October 18, 2010. The sponsoring agency is the National Institutes of Health. Additional details and the full announcement were provided through the NIH grants guide (PAR-08-139), and NIH’s Office of Extramural Research webmaster contacts were listed for technical access or linking problems.

Frequently Asked Questions (FAQs) - NIH PAR-08-139: Enhancing Zebrafish Research with Research Tools and Techniques (R01)

What is NIH PAR-08-139?

PAR-08-139 is an NIH funding opportunity titled "Enhancing Zebrafish Research with Research Tools and Techniques (R01)." It supports investigator-initiated R01 research projects focused on strengthening and expanding zebrafish (Danio rerio) as a widely used vertebrate model for biomedical and behavioral science.

What is the main goal of this funding opportunity?

The central goal is to create or significantly improve broadly useful research tools and techniques for zebrafish research. The emphasis is on deliverables that the larger zebrafish community can adopt, rather than projects that mainly run zebrafish experiments without producing a widely enabling tool or method.

What kinds of projects are most responsive to this FOA?

The most responsive projects propose enabling technologies that make it easier to detect, measure, and interpret genes, pathways, and phenotypes in zebrafish across a wide range of biological and disease areas. Projects that address widely recognized bottlenecks or unmet needs in the zebrafish field are highlighted as a strong fit.

Is this opportunity meant for basic zebrafish experiments?

No. While zebrafish experiments may be part of the work, the stated aim is not simply to conduct zebrafish studies. The focus is tool and technique development (or significant improvement of existing methods) that can be adopted broadly.

What scientific areas does the FOA emphasize?

The opportunity is geared toward tool and method development that advances zebrafish studies in areas where the model is especially powerful, including development and aging, organ formation and function, neural processes, behavior and sensory processing, physiological regulation, and disease mechanisms.

What types of improvements are encouraged for tools and techniques?

Competitive applications would typically improve how researchers identify and characterize genetic and molecular pathways, connect pathways to observable traits, and measure phenotypes with greater precision, throughput, or biological relevance.

What does "community priority" mean in this context?

"Community priority" refers to NIH's emphasis on tools and methods that address widely recognized needs or bottlenecks across zebrafish research, rather than highly specialized tools designed mainly for a single lab's narrow use case.

Who is coordinating the broader NIH zebrafish initiative connected to this FOA?

This FOA is part of a broader NIH initiative organized through the Trans-NIH Zebrafish Coordinating Committee (TZCC), which is co-chaired by NICHD and NIDDK. This signals cross-institute interest in zebrafish resource and technology development.

Why are there many CFDA program numbers associated with this announcement?

The wide set of CFDA program numbers indicates NIH intends the supported tools and technologies to have broad relevance across many disease and basic science missions. The associated areas span topics such as environmental health, genomics, hearing and communication disorders, sleep, mental health, alcohol and drug abuse, cancer biology, cardiovascular and blood diseases, diabetes and kidney disease, neuroscience and neurological disorders, child health and development, aging, and vision research.

What is the funding mechanism for PAR-08-139?

The mechanism of support is the NIH Research Project Grant (R01). This mechanism generally supports well-developed research plans expected to produce a substantial, validated deliverable within an R01-typical scope and timeline.

Does this FOA guarantee awards or a specific number of funded projects?

No. Awards are contingent on the availability of funds and on NIH receiving a sufficient number of highly meritorious applications. The announcement does not guarantee a specific number of awards.

Is cost sharing or matching required?

No. The opportunity explicitly states there is no cost sharing or matching requirement.

Who is eligible to apply?

Eligibility is broad and includes many types of U.S. and non-U.S. organizations, including public and private institutions of higher education, nonprofits (including both 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), and government entities (state, county, city/township, special district, and tribal governments).

Are foreign organizations eligible?

Yes. The eligibility language explicitly includes foreign organizations.

Are U.S. territories and possessions included in eligibility?

Yes. The eligibility language explicitly includes U.S. territories and possessions.

Does the eligibility language mention specific institution types?

Yes. It explicitly includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities.

Which agency sponsors this funding opportunity?

The sponsoring agency is the National Institutes of Health (NIH).

When was this opportunity posted, and what were the key dates?

The opportunity was posted on April 9, 2008. The closing date was September 17, 2010. It was archived on October 18, 2010.

Where were full details provided?

Additional details and the full announcement were provided through the NIH grants guide under PAR-08-139.

Who was listed for technical help with access or linking issues?

NIH's Office of Extramural Research webmaster contacts were listed for technical access or linking problems related to the announcement.

Browse more opportunities from the same agency: National Institutes of Health

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Previous opportunity: Genetic Screens to Enhance Zebrafish Research (R01)

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