Opportunity Information: Apply for IR ORI 26 001

  • The Office of the Assistant Secretary for Health in the other sector is offering a public funding opportunity titled "Ensuring Research Integrity – Research on Research Integrity Program (RRI)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.085.
  • This funding opportunity was created on 2026-06-25.
  • Applicants must submit their applications by 2026-07-27. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $250,000.00 in funding.
  • The number of recipients for this funding is limited to 2 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses.
Apply for IR ORI 26 001

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Opportunity Summary:

The Ensuring Research Integrity - Research on Research Integrity Program (RRI) (Funding Opportunity Number: IR ORI 26 001) is a discretionary grant opportunity offered by the Office of the Assistant Secretary for Health (CFDA 93.085). It supports empirical research aimed at understanding why research misconduct happens and what conditions help prevent it, with an explicit emphasis on alignment with the federal research misconduct regulation at 42 C.F.R. part 93. In practice, this means the program is looking for evidence-based studies that go beyond general discussions of ethics and instead generate data and analysis about the real-world drivers of integrity and misconduct across the research ecosystem.

The central purpose of the program is to identify root causes of research misconduct and pinpoint factors that strengthen research integrity at multiple levels, including societal influences, organizational and institutional environments, group dynamics within labs or teams, and individual behaviors and decision-making. The program is designed to fund projects that can produce actionable findings, such as insights that improve institutional oversight, strengthen responsible conduct of research efforts, and enhance the fairness and effectiveness of how concerns are surfaced and handled.

Applicants must propose research that addresses any combination of four focus areas. First, projects may explore financial, cultural, institutional, and individual factors that shape integrity outcomes. This can include studying incentive structures (such as funding pressures, publication expectations, promotion criteria, or performance metrics), workplace climate and mentorship norms, unequal power dynamics, resource constraints, and other conditions that may increase vulnerability to misconduct or, conversely, reinforce transparency and rigor. Second, projects may assess the effectiveness of policies and training. This area is aimed at evaluating whether specific institutional policies, compliance approaches, responsible conduct training models, mentorship interventions, or research culture initiatives actually change behavior and reduce questionable practices, and under what circumstances they work best. Third, projects may investigate reporting and response mechanisms, focusing on how concerns are raised, how institutions triage and investigate allegations, what barriers discourage reporting, and what practices lead to credible, timely, and trusted responses. Fourth, the program explicitly calls for examination of artificial intelligence (AI) as either a driver of research integrity or a risk factor for misconduct, recognizing that AI tools can both strengthen research practices (for example by supporting reproducibility, data checks, or literature screening) and create new integrity risks (such as fabricated text, synthetic data misuse, image manipulation, or obscured provenance of analyses).

Eligibility is broad and includes federal-recognized tribal governments and tribal organizations, state and local governments (including counties, cities or townships, special districts, and public housing authorities), independent school districts, public and private institutions of higher education, nonprofits (both 501(c)(3) and non-501(c)(3)), for-profit organizations other than small businesses, and small businesses. This wide eligibility suggests the program is open to proposals from universities and research institutes as well as organizations that study research systems, develop compliance and training interventions, or have access to relevant datasets and research communities.

The funding instrument is a grant, with an award ceiling of $250,000 per award, and the agency expects to make 2 awards. The opportunity was created on 2026-06-25, and the original application closing date is 2026-07-27. Overall, the program is best suited for applicants prepared to run rigorous, data-driven studies on the causes and prevention of misconduct, evaluate the real-world performance of integrity policies and training, examine how reporting and institutional response systems function in practice, and address emerging challenges and opportunities created by AI in the research lifecycle.

Frequently Asked Questions (FAQs)

What is the Ensuring Research Integrity - Research on Research Integrity Program (RRI)?

The Ensuring Research Integrity - Research on Research Integrity Program (RRI) is a discretionary grant opportunity (Funding Opportunity Number: IR ORI 26 001) offered by the Office of the Assistant Secretary for Health. It supports empirical research designed to understand why research misconduct happens and what conditions help prevent it, with an explicit emphasis on alignment with the federal research misconduct regulation at 42 C.F.R. part 93.

What is the CFDA number for this opportunity?

The CFDA listing associated with this program is 93.085.

What is the main purpose of this funding opportunity?

The program is intended to identify root causes of research misconduct and pinpoint factors that strengthen research integrity across multiple levels of influence, including societal factors, organizational and institutional environments, group dynamics in labs or teams, and individual behaviors and decision-making. The goal is to generate actionable findings that can improve oversight, responsible conduct of research efforts, and the fairness and effectiveness of how concerns are raised and handled.

Is this grant focused on ethics education in general, or on empirical research?

This opportunity emphasizes evidence-based, empirical studies that generate data and analysis about real-world drivers of integrity and misconduct. It is positioned as going beyond general discussions of ethics by funding research that produces measurable, actionable insights.

What regulation is explicitly emphasized in this program?

The program explicitly emphasizes alignment with the federal research misconduct regulation at 42 C.F.R. part 93.

What kinds of research questions is the program trying to answer?

Supported projects are expected to help explain why misconduct occurs and what conditions prevent it, including how incentives, organizational environments, team dynamics, and individual decisions affect integrity outcomes, and what institutional practices lead to more credible and trusted reporting and response processes.

What are the four focus areas applicants can address?

Applicants must propose research addressing any combination of these four focus areas:

  • Financial, cultural, institutional, and individual factors that shape integrity outcomes
  • Effectiveness of policies and training
  • Reporting and response mechanisms
  • Artificial intelligence (AI) as a driver of integrity or a risk factor for misconduct

Do applicants have to address all four focus areas?

No. Applicants must propose research that addresses any combination of the four focus areas, meaning proposals may cover one area or multiple areas.

What does the program mean by studying financial, cultural, institutional, and individual factors?

This focus area includes research on incentive structures and pressures (such as funding pressures, publication expectations, promotion criteria, or performance metrics), workplace climate and mentorship norms, unequal power dynamics, resource constraints, and other conditions that may increase vulnerability to misconduct or reinforce transparency and rigor.

What does "effectiveness of policies and training" refer to in this opportunity?

This focus area targets evaluations of whether institutional policies, compliance approaches, responsible conduct training models, mentorship interventions, or research culture initiatives actually change behavior and reduce questionable practices, and under what conditions they work best.

What does the program mean by "reporting and response mechanisms"?

This focus area includes research on how concerns are raised, how institutions triage and investigate allegations, barriers that discourage reporting, and practices that lead to credible, timely, and trusted institutional responses.

How does artificial intelligence (AI) fit into the scope of this program?

The opportunity explicitly calls for examination of AI as either a driver of research integrity or a risk factor for misconduct. The program recognizes that AI tools can strengthen research practices (for example, supporting reproducibility, data checks, or literature screening) while also introducing risks (such as fabricated text, synthetic data misuse, image manipulation, or obscured provenance of analyses).

What types of organizations are eligible to apply?

Eligibility is broad and includes:

  • Federal-recognized tribal governments and tribal organizations
  • State and local governments (including counties, cities or townships, special districts, and public housing authorities)
  • Independent school districts
  • Public and private institutions of higher education
  • Nonprofits (501(c)(3) and non-501(c)(3))
  • For-profit organizations other than small businesses
  • Small businesses

Are universities and research institutes eligible?

Yes. Public and private institutions of higher education are explicitly listed as eligible, and the broad eligibility indicates the program is open to universities and research institutes as well as other organizations that study research systems or implement integrity-related interventions.

Are small businesses eligible?

Yes. Small businesses are explicitly included in the eligibility list.

Are for-profit organizations eligible?

Yes. For-profit organizations other than small businesses are listed as eligible, and small businesses are also eligible.

What is the funding instrument for this opportunity?

The funding instrument is a grant.

What is the maximum award amount (award ceiling)?

The award ceiling is $250,000 per award.

How many awards does the agency expect to make?

The agency expects to make 2 awards.

What is the application closing date?

The original application closing date is 2026-07-27.

When was this opportunity created?

The opportunity was created on 2026-06-25.

What kinds of projects are a good fit for this program?

The program is best suited for applicants prepared to run rigorous, data-driven studies on: (1) causes and prevention of misconduct; (2) real-world performance of integrity policies, compliance approaches, and training; (3) how reporting and institutional response systems function in practice; and/or (4) emerging challenges and opportunities created by AI in the research lifecycle.

What outcomes is the program aiming to support?

The program is designed to fund projects that produce actionable findings, including insights that improve institutional oversight, strengthen responsible conduct of research efforts, and enhance the fairness and effectiveness of how concerns are surfaced and handled.

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