Opportunity Information: Apply for PA 12 133

  • The National Institutes of Health in the education environment health sector is offering a public funding opportunity titled "Environmental Exposures and Health Exploration of Non Traditional Settings, (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.361 Nursing Research.
  • This funding opportunity was created on Mar 23, 2012 and posted on Mar 23, 2012.
  • Applicants must submit their applications by Jan 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Native American tribal governments (Federally recognized) Private institutions of higher education City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Independent school districts Public housing authorities/Indian housing authorities State governments Special district governments For profit organizations other than small businesses Public and State controlled institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The Environmental Exposures and Health Exploration of Non Traditional Settings (R01) grant opportunity (Funding Opportunity Number PA-12-133) was a discretionary National Institutes of Health (NIH) funding announcement led by the National Institute of Nursing Research (NINR) in partnership with the National Institute of Environmental Health Sciences (NIEHS). It sought to fund interdisciplinary research projects that examine how environmental pollutants and toxins affect health in two priority populations, children and older adults, specifically when they live in or spend substantial time in non traditional settings. The larger goal was to generate evidence that can be used to promote health, limit symptoms and disease, and reduce health disparities, while also advancing nursing science through a strong focus on real-world prevention, symptom management, and health-supporting behaviors at the individual, family, and community levels.

A central idea in the announcement is that many vulnerable people are not primarily exposed to environmental risks only in homes or conventional institutions, but in a wide range of everyday or alternative environments where exposures may be underrecognized, understudied, or poorly managed. The FOA therefore emphasized research that improves risk identification and understanding of exposure pathways in these settings, along with studies that test strategies to prevent or reduce harm. The health outcomes of interest included conditions linked to environmental exposures such as lower respiratory diseases, chronic obstructive pulmonary disease (COPD), and cardiovascular diseases, along with related symptoms and broader health consequences. In practice, this meant projects could focus on identifying environmental hazards, measuring or characterizing exposure profiles, linking exposures to symptoms or disease trajectories, and developing or evaluating interventions that reduce exposure, lessen symptom burden, or strengthen protective behaviors and community actions.

For the purposes of this opportunity, "non traditional settings" were defined broadly to capture places where children and older adults may spend meaningful amounts of time outside standard home or school models. Examples listed in the announcement included community centers and pre-school settings, as well as non traditional school environments such as churches hosting educational programs, daycare sites, home-based schools, dormitories, and alternative schools. The FOA also explicitly included child and older adult foster care facilities, older adult day care facilities, half way homes, assisted living settings, and long term care facilities. By highlighting these locations, NIH signaled interest in research that reflects where daily life actually happens for many families and older adults, including settings tied to care transitions, housing instability, or community-based support systems that may contribute to disparities in environmental risk and health outcomes.

The funding mechanism was the NIH R01 research project grant, which generally supports hypothesis-driven, investigator-initiated research of a scope and duration sufficient to produce a substantial body of findings. The FOA fell under the activity categories of education, environment, and health, and referenced CFDA numbers 93.113 (Environmental Health) and 93.361 (Nursing Research). Cost sharing or matching was not required, which is typical for NIH research grants and can lower barriers to participation for organizations that do not have discretionary resources to contribute.

Eligibility was intentionally broad and included a wide array of organizational types. Eligible applicants included public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) organizations), for-profit organizations (including small businesses and other for-profits), and multiple levels of government entities such as state, county, city or township, special district governments, independent school districts, and public housing authorities or Indian housing authorities. The FOA also noted additional eligible applicants such as faith-based and community-based organizations, federally recognized and other tribal governments and tribal organizations, Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, regional organizations, eligible federal agencies, and U.S. territories or possessions. Importantly, it allowed non-U.S. entities (foreign institutions) to apply, permitted non-U.S. components of U.S. organizations, and allowed foreign components as defined by NIH policy, signaling that the science questions could be addressed in international contexts when relevant and justified.

In terms of timing and status, the opportunity was posted and created on March 23, 2012, with an original and final closing date of January 7, 2016. It was archived on February 7, 2016, meaning it is no longer open for new applications under that specific announcement. The full archived announcement was made available through the NIH Grants Guide at the link provided in the source, and NIH Office of Extramural Research (OER) web support contacts were listed for access or linking issues.

Overall, PA-12-133 aimed to push research beyond traditional clinical or home-based environmental health studies by focusing on the real-life, often overlooked settings where children and older adults may face meaningful environmental exposures. It emphasized interdisciplinary approaches and practical, prevention-oriented solutions grounded in nursing and community health perspectives, with an explicit intent to reduce disparities and improve symptom management and long-term health outcomes in vulnerable populations.

Frequently Asked Questions (FAQs)

What is the Environmental Exposures and Health Exploration of Non Traditional Settings (R01) opportunity?

It was a National Institutes of Health (NIH) funding opportunity announcement for an R01 research project grant titled "Environmental Exposures and Health Exploration of Non Traditional Settings (R01)." The Funding Opportunity Number was PA-12-133.

Which NIH institutes led and partnered on this funding opportunity?

The announcement was led by the National Institute of Nursing Research (NINR) in partnership with the National Institute of Environmental Health Sciences (NIEHS).

What was the main purpose or goal of PA-12-133?

The goal was to fund interdisciplinary research that examines how environmental pollutants and toxins affect health for two priority populations, children and older adults, when they live in or spend substantial time in non traditional settings. The broader intent was to generate evidence that can promote health, limit symptoms and disease, reduce health disparities, and advance nursing science with a real-world focus on prevention, symptom management, and health-supporting behaviors at individual, family, and community levels.

What populations were prioritized in this grant opportunity?

Children and older adults were the two priority populations emphasized in the announcement.

What does NIH mean by "non traditional settings" in this FOA?

"Non traditional settings" were defined broadly as places where children and older adults may spend meaningful amounts of time outside standard home or school models, especially where exposures may be underrecognized, understudied, or poorly managed.

What are examples of "non traditional settings" listed in the announcement?

Examples included community centers and pre-school settings; non traditional school environments such as churches hosting educational programs, daycare sites, home-based schools, dormitories, and alternative schools; as well as child and older adult foster care facilities, older adult day care facilities, half way homes, assisted living settings, and long term care facilities.

Why did the FOA emphasize non traditional settings instead of only homes or conventional institutions?

A central premise was that many vulnerable people are not primarily exposed to environmental risks only in homes or conventional institutions. Instead, exposures may occur in a wide range of everyday or alternative environments, and those exposures may be overlooked or poorly managed. The FOA sought research that reflects where daily life happens, including settings associated with care transitions, housing instability, or community-based supports that may contribute to disparities in risk and outcomes.

What types of environmental risks or agents were the focus?

The FOA focused on environmental pollutants and toxins, with an emphasis on identifying hazards, understanding exposure pathways, and examining how these exposures relate to symptoms and disease.

What kinds of health outcomes were of interest?

The announcement highlighted conditions linked to environmental exposures such as lower respiratory diseases, chronic obstructive pulmonary disease (COPD), and cardiovascular diseases, along with related symptoms and broader health consequences.

What kinds of research activities or aims fit the scope of PA-12-133?

The announcement described projects that could include identifying environmental hazards; measuring or characterizing exposure profiles; linking exposures to symptoms or disease trajectories; and developing or evaluating interventions that reduce exposure, lessen symptom burden, or strengthen protective behaviors and community actions.

Did the FOA encourage intervention-focused research, or only observational exposure studies?

It emphasized both improving risk identification and understanding exposure pathways in non traditional settings and studies that test strategies to prevent or reduce harm. In other words, both exposure characterization and prevention or mitigation strategies were within scope.

What does "interdisciplinary research" mean in the context of this opportunity?

The FOA sought interdisciplinary projects that connect environmental exposure science with health outcomes and practical prevention and symptom management approaches, including perspectives grounded in nursing and community health.

What funding mechanism was used?

The funding mechanism was the NIH R01 research project grant.

What does an NIH R01 generally support?

As described in the opportunity summary, the R01 generally supports hypothesis-driven, investigator-initiated research of a scope and duration sufficient to produce a substantial body of findings.

What activity areas did the FOA fall under?

The activity categories referenced were education, environment, and health.

Which CFDA numbers were referenced for this opportunity?

The announcement referenced CFDA 93.113 (Environmental Health) and 93.361 (Nursing Research).

Was cost sharing or matching required?

No. Cost sharing or matching was not required.

Who was eligible to apply?

Eligibility was broad and included many organization types: public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) organizations), and for-profit organizations (including small businesses and other for-profits).

Were government entities eligible applicants?

Yes. Eligible applicants included state, county, city or township governments, special district governments, independent school districts, and public housing authorities or Indian housing authorities.

Were community-based, faith-based, and tribal organizations eligible?

Yes. The FOA listed faith-based and community-based organizations, federally recognized and other tribal governments, and tribal organizations as eligible applicants.

Were minority-serving institutions specifically included in the eligibility list?

Yes. The eligibility list included Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), and Alaska Native and Native Hawaiian-serving institutions.

Were U.S. territories or possessions eligible?

Yes. U.S. territories or possessions were included among eligible applicants.

Could foreign (non-U.S.) institutions apply?

Yes. The FOA allowed non-U.S. entities (foreign institutions) to apply. It also permitted non-U.S. components of U.S. organizations and allowed foreign components as defined by NIH policy.

When was PA-12-133 posted and when did it close?

The opportunity was posted and created on March 23, 2012. The original and final closing date was January 7, 2016.

Is this funding opportunity still open?

No. The opportunity was archived on February 7, 2016, which means it is no longer open for new applications under that specific announcement.

Where could applicants find the full announcement materials?

The full archived announcement was available through the NIH Grants Guide (as referenced in the source information).

Who was listed for technical help with access or linking issues?

NIH Office of Extramural Research (OER) web support contacts were listed for access or linking issues.

What was the intended real-world impact of the research funded under this FOA?

The FOA aimed to generate evidence that can be used to promote health, limit symptoms and disease, reduce health disparities, and support practical prevention-oriented solutions in the everyday settings where children and older adults spend time.

How did this opportunity connect to nursing science?

It explicitly aimed to advance nursing science by emphasizing real-world prevention, symptom management, and health-supporting behaviors at the individual, family, and community levels, alongside environmental exposure and health research.

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