Opportunity Information: Apply for CDC RFA CK16 1606
Apply for CDC RFA CK16 1606
- The HHS-CDC-NCEZID in the health sector is offering a public funding opportunity titled "Environmental Sampling with NAU for High Consequence Pathogens" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.283.
- This funding opportunity was created on May 13, 2016 and posted on May 13, 2016.
- Applicants must submit their applications by Jul 11, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $300,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education.
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Opportunity Summary:
The Environmental Sampling with NAU for High Consequence Pathogens opportunity (CDC RFA CK16-1606) is a CDC cooperative agreement focused on improving understanding of where Burkholderia pseudomallei exists in the environment and which locations may pose higher risk for human disease. Burkholderia pseudomallei is the bacterium that causes melioidosis and is known to persist in soil and water under certain environmental conditions. The grant centers on using established knowledge about favorable soil and water characteristics, along with CDC-led serologic surveillance data from patients with febrile illness, to more strategically choose sampling sites and generate a clearer picture of environmental distribution.
The project approach is driven by environmental predictors that have been associated with B. pseudomallei presence, including factors such as pH, particle size, salinity, moisture content, and total nitrogen. Rather than sampling randomly, the awardee is expected to integrate these soil characteristics with results from ongoing serologic studies conducted by CDCs Zoonotic and Select Agent Laboratory within the Bacterial Special Pathogens Branch. Those serologic studies look for evidence of exposure in patients presenting with fever, and the combined information is intended to guide identification of geographic areas that are most suitable and informative for environmental sampling.
A key deliverable is substantial field collection: at minimum, 500 soil samples and 100 water samples must be collected over the project period. After collection, samples are shipped either to the collecting institution or to CDC for laboratory work, including culture-based detection and genotypic studies. Culture work aims to isolate the organism when present, while genotyping supports deeper characterization, such as comparing strains, understanding diversity, and informing how environmental isolates may relate to patterns of human exposure.
The expected outcome is practical and public health oriented. By pairing targeted sampling with laboratory confirmation and genetic characterization, the study is designed to produce a more accurate understanding of where B. pseudomallei is present in the environment and to help identify higher risk areas for disease. This kind of mapping and characterization can support better risk assessment, guide future surveillance and prevention strategies, and improve situational awareness for a high consequence pathogen that can be difficult to detect without systematic sampling.
Administratively, the opportunity was offered by HHS/CDC within NCEZID as a discretionary cooperative agreement in the health activity category (CFDA 93.283). Eligibility was limited to public and state-controlled institutions of higher education, reflecting the expectation of strong field research capacity and laboratory coordination. The funding had an award ceiling of $300,000, with one award anticipated. The opportunity was posted May 13, 2016, created May 13, 2016, and closed July 11, 2016.
Frequently Asked Questions (FAQs)
What is the Environmental Sampling with NAU for High Consequence Pathogens opportunity (CDC RFA CK16-1606)?
This opportunity is a CDC cooperative agreement focused on improving understanding of where Burkholderia pseudomallei exists in the environment and identifying locations that may pose higher risk for human disease.
Which pathogen is the focus of this cooperative agreement?
The project focuses on Burkholderia pseudomallei, the bacterium that causes melioidosis. It is known to persist in soil and water under certain environmental conditions.
What is the main purpose of the project?
The project is designed to create a clearer picture of the environmental distribution of B. pseudomallei. It does this by using existing knowledge about favorable soil and water characteristics and combining that with CDC-led serologic surveillance data from patients with febrile illness to strategically select environmental sampling locations.
Why does the opportunity emphasize targeted sampling instead of random sampling?
Rather than sampling randomly, the awardee is expected to use environmental predictors and CDC serologic surveillance data to select sampling sites that are most suitable and informative. The intent is to increase the chance of detecting the organism and improve understanding of where it may be present.
What environmental predictors are used to guide sampling site selection?
The approach is driven by environmental predictors that have been associated with B. pseudomallei presence, including pH, particle size, salinity, moisture content, and total nitrogen.
How are CDC serologic surveillance data used in this project?
The awardee is expected to integrate soil and water characteristics with results from ongoing CDC-led serologic studies. These serologic studies look for evidence of exposure in patients presenting with fever, and the combined information is intended to guide identification of geographic areas that are most suitable for environmental sampling.
Which CDC group conducts the serologic studies referenced in the opportunity?
The serologic studies are conducted by CDC's Zoonotic and Select Agent Laboratory within the Bacterial Special Pathogens Branch.
What are the minimum sampling deliverables required under this project?
A key deliverable is field collection of at least 500 soil samples and 100 water samples over the project period.
What happens to the samples after they are collected?
After collection, samples are shipped either to the collecting institution or to CDC for laboratory work, including culture-based detection and genotypic studies.
What laboratory methods are mentioned for analyzing collected samples?
The opportunity specifies culture-based detection to isolate the organism when present, and genotypic studies to support deeper characterization of isolates.
What is the purpose of the genotypic studies in this project?
Genotyping is intended to provide deeper characterization, such as comparing strains, understanding diversity, and informing how environmental isolates may relate to patterns of human exposure.
What outcomes is CDC expecting from this cooperative agreement?
The expected outcomes are public health oriented: a more accurate understanding of where B. pseudomallei is present in the environment and improved ability to identify higher risk areas for disease. This can support better risk assessment, guide future surveillance and prevention strategies, and improve situational awareness for a high consequence pathogen that can be difficult to detect without systematic sampling.
Which agency and CDC center offered this opportunity?
The opportunity was offered by HHS/CDC within NCEZID.
What type of award mechanism is this?
It is a discretionary cooperative agreement.
What is the CFDA number and health activity category?
The health activity category is listed as health activity, and the CFDA number is 93.283.
Who was eligible to apply?
Eligibility was limited to public and state-controlled institutions of higher education, reflecting an expectation of strong field research capacity and laboratory coordination.
How much funding was available and how many awards were anticipated?
The award ceiling was $300,000, and one award was anticipated.
When was the opportunity posted and when did it close?
The opportunity was posted May 13, 2016, created May 13, 2016, and closed July 11, 2016.
What is the practical public health value of mapping environmental distribution of this organism?
By pairing targeted sampling with laboratory confirmation and genetic characterization, the work is intended to improve situational awareness and support future risk assessment, surveillance, and prevention strategies related to melioidosis risk and environmental presence of B. pseudomallei.
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