Opportunity Information: Apply for RFA CI 11 001
Apply for RFA CI 11 001
- The Centers for Disease Control and Prevention in the health sector is offering a public funding opportunity titled "Epi Centers for the Prevention of Healthcare Associated Infections, Antimicrobial Resistance and Adverse Events (U54)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.283 Centers for Disease Control and PreventionInvestigations and Technical Assistance.
- This funding opportunity was created on Jul 30, 2010 and posted on Jul 30, 2010.
- Applicants must submit their applications by Sep 30, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $8,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $2,000,000.00 in funding.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
- Eligible Institutions You may submit an application(s) if your organization has any of the following characteristics Public nonprofit organizations Private nonprofit organizations For profit organizations Small, minority, and women owned businesses Universities Colleges Research institutions Hospitals Community based organizations Faith based organizations Federally recognized or state recognized American Indian/Alaska Native tribal governments American Indian/Alaska Native tribally designated organizations Alaska Native health corporations Urban Indian health organizations Tribal epidemiology centers State and local governments or their Bona Fide Agents (this includes the District of Columbia, the Commonwealth of Puerto Rico, the Virgin Islands, the Commonwealth of the Northern Marianna Islands, American Samoa, Guam, the Federated States of Micronesia, the Republic of the Marshall Islands, and the Republic of Palau) Political subdivisions of States (in consultation with States) A Bona Fide Agent is an agency/organization identified by the state as eligible to submit an application under the state eligibility in lieu of a state application. If you are applying as a bona fide agent of a state or local government, signed by the State/Local government and the agent, as documentation of your status you must provide a letter from the state or local government as documentation of your status
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Opportunity Summary:
The Epi Centers for the Prevention of Healthcare Associated Infections, Antimicrobial Resistance and Adverse Events (U54) opportunity (Funding Opportunity Number RFA CI 11 001) was a CDC cooperative agreement designed to strengthen the nations ability to prevent infections and other harms that occur in healthcare settings. It was issued by the Centers for Disease Control and Prevention (CDC) within the U.S. Department of Health and Human Services (HHS), specifically through the National Center for Emerging and Zoonotic Infectious Diseases (NCEZID). The program was framed as part of CDCs broader prevention mission and tied directly to federal performance and accountability expectations under the Government Performance and Results Act (GPRA), meaning applicants were expected to contribute to measurable public health outcomes rather than conduct stand-alone research with no operational impact.
The focus of the solicitation centered on three major public health priorities drawn from Healthy People 2010: reducing hospital-acquired infections among intensive care unit patients, reducing central line-associated bloodstream infections, and reducing the incidence of invasive methicillin-resistant Staphylococcus aureus (MRSA) infections. In practical terms, the Epi Centers concept was intended to build applied epidemiology capacity and support coordinated, data-driven prevention work aimed at lowering healthcare-associated infection burdens, slowing antimicrobial resistance, and reducing adverse events tied to healthcare delivery. The opportunity also aligned with NCEZIDs proposed performance goals to protect Americans from infectious diseases, reinforcing that the work was expected to translate into real prevention improvements across healthcare systems.
This funding was offered as a cooperative agreement (U54), which typically indicates a substantial level of federal involvement compared with a standard grant. Under a cooperative agreement structure, recipients generally collaborate closely with CDC on planning, implementation, and performance monitoring, and CDC may provide ongoing technical assistance and scientific direction to ensure the work supports national surveillance and prevention strategies. The activity category was Health, and the underlying CFDA number listed was 93.283, identified as Centers for Disease Control and Prevention Investigations and Technical Assistance.
The announcement anticipated making 4 awards, with an estimated total funding level of $8,000,000. The stated award ceiling was $2,000,000, and the award floor was $0, signaling that awards could vary in size up to the maximum depending on the scope and quality of proposals and CDC program priorities. There was no cost sharing or matching requirement, which lowered the barrier to participation for organizations that might not be able to provide significant non-federal funds.
Eligibility was broad and included a wide mix of public, private, academic, clinical, tribal, and governmental entities. Eligible applicants included public and private nonprofit organizations, for-profit organizations including small, minority-owned, and women-owned businesses, and a range of academic and research institutions such as universities, colleges, and research institutes. Hospitals, community-based organizations, and faith-based organizations were also eligible, reflecting the expectation that prevention work may require partnerships spanning healthcare delivery sites and community networks. Government eligibility included state and local governments and their bona fide agents (including U.S. territories and freely associated states listed in the notice), as well as political subdivisions of states in consultation with states. Tribal eligibility was explicitly included, such as federally or state-recognized American Indian/Alaska Native tribal governments, tribally designated organizations, Alaska Native health corporations, Urban Indian health organizations, tribal epidemiology centers, and related entities. Applicants applying as a bona fide agent were required to provide documentation of that status through a letter signed by both the state or local government and the agent.
Key dates show the opportunity was posted and created on July 30, 2010, with an application closing date of September 30, 2010, and an archive date of October 30, 2010. For applicants needing help accessing the full announcement, CDCs Procurement and Grants Office TIMS provided support via phone (770-488-2700) and email (PGOTIM@cdc.gov). Additional contextual information in the notice pointed applicants to Healthy People 2010 resources at www.healthypeople.gov as the national framework underpinning the priority outcomes the program sought to improve.
Frequently Asked Questions (FAQs)
What is the Epi Centers for the Prevention of Healthcare Associated Infections, Antimicrobial Resistance and Adverse Events (U54) opportunity?
It is a CDC cooperative agreement (U54) funding opportunity intended to strengthen the nation's ability to prevent infections and other harms that occur in healthcare settings. The program concept emphasized applied epidemiology capacity and coordinated, data-driven prevention work focused on healthcare-associated infections (HAIs), antimicrobial resistance, and adverse events related to healthcare delivery.
What is the Funding Opportunity Number for this announcement?
The Funding Opportunity Number is RFA CI 11 001.
Which federal agency and department issued this opportunity?
The opportunity was issued by the Centers for Disease Control and Prevention (CDC) within the U.S. Department of Health and Human Services (HHS), specifically through the National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).
What is the CFDA number associated with this opportunity?
The CFDA number listed is 93.283, identified as Centers for Disease Control and Prevention Investigations and Technical Assistance.
What type of funding mechanism is this (grant vs. cooperative agreement)?
This is a cooperative agreement (U54). Compared with a standard grant, a cooperative agreement typically involves substantial federal involvement, meaning recipients generally work closely with CDC on planning, implementation, and performance monitoring, and CDC may provide technical assistance and scientific direction.
What public health priorities does the solicitation focus on?
The solicitation centered on three major public health priorities drawn from Healthy People 2010:
- Reducing hospital-acquired infections among intensive care unit (ICU) patients
- Reducing central line-associated bloodstream infections (CLABSIs)
- Reducing the incidence of invasive methicillin-resistant Staphylococcus aureus (MRSA) infections
How does Healthy People 2010 relate to this funding opportunity?
Healthy People 2010 served as the national framework underpinning the priority outcomes this program sought to improve. The solicitation explicitly tied its focus areas to Healthy People 2010 objectives and referenced Healthy People resources at www.healthypeople.gov.
What is the intended purpose of the Epi Centers concept in practical terms?
The Epi Centers concept was intended to build applied epidemiology capacity and support coordinated prevention work aimed at lowering healthcare-associated infection burdens, slowing antimicrobial resistance, and reducing adverse events tied to healthcare delivery across healthcare systems.
Is this program primarily research-focused?
The program was framed around measurable prevention outcomes and operational impact. Applicants were expected to contribute to real-world improvements in prevention and public health performance rather than conduct stand-alone research with no operational impact.
How does GPRA factor into expectations for applicants?
The opportunity was tied to federal performance and accountability expectations under the Government Performance and Results Act (GPRA). This means the work was expected to support measurable public health outcomes aligned with CDC performance goals.
What is the activity category for this opportunity?
The activity category listed is Health.
How many awards were anticipated?
The announcement anticipated making 4 awards.
What was the estimated total funding amount for the program?
The estimated total funding level was $8,000,000.
What was the maximum award amount (award ceiling)?
The stated award ceiling was $2,000,000.
What does it mean that the award floor is listed as $0?
An award floor of $0 indicates awards could vary in size and were not guaranteed to meet a stated minimum amount. Funding levels could be set up to the ceiling depending on proposal scope and quality and CDC program priorities.
Is cost sharing or matching required?
No. The announcement stated there was no cost sharing or matching requirement.
Who was eligible to apply?
Eligibility was broad and included public, private, academic, clinical, tribal, and governmental entities. Eligible applicants included:
- Public and private nonprofit organizations
- For-profit organizations, including small, minority-owned, and women-owned businesses
- Universities, colleges, research institutes, and other academic/research institutions
- Hospitals
- Community-based organizations
- Faith-based organizations
- State and local governments and their bona fide agents (including U.S. territories and freely associated states listed in the notice)
- Political subdivisions of states in consultation with states
- Tribal entities, including federally or state-recognized American Indian/Alaska Native tribal governments and related tribal organizations
Which tribal and tribal-related organizations were explicitly included as eligible?
The notice explicitly included eligibility for entities such as federally or state-recognized American Indian/Alaska Native tribal governments, tribally designated organizations, Alaska Native health corporations, Urban Indian health organizations, tribal epidemiology centers, and related entities.
What is meant by applying as a "bona fide agent" of a government?
The notice allowed state and local governments and their bona fide agents to apply. Applicants applying as a bona fide agent were required to provide documentation of that status through a letter signed by both the state or local government and the agent.
What documentation was required for bona fide agent applicants?
A letter documenting bona fide agent status was required, and it needed to be signed by both the state or local government and the agent.
When was the opportunity posted and when did it close?
The opportunity was posted/created on July 30, 2010. The application closing date was September 30, 2010.
When was the opportunity archived?
The archive date listed was October 30, 2010.
Where could applicants get help accessing the full announcement?
Applicants needing help accessing the full announcement were directed to CDC's Procurement and Grants Office TIMS via phone at 770-488-2700 or by email at PGOTIM@cdc.gov.
How does this opportunity connect to CDC/NCEZID performance goals?
The notice described the opportunity as aligned with NCEZID's proposed performance goals to protect Americans from infectious diseases, reinforcing that funded work was expected to translate into real prevention improvements across healthcare systems.
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