Opportunity Information: Apply for RFA CK 15 004

  • The Centers for Disease Control and Prevention in the health sector is offering a public funding opportunity titled "Epicenters for the Prevention of Healthcare Associated Infections (HAI) Cycle II" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.823 Ebola Support Transmission and Prevention Control, Public Health Preparedness, Vaccine Development.
  • This funding opportunity was created on May 8, 2015 and posted on Apr 1, 2015.
  • Applicants must submit their applications by Jun 1, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $11,000,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $2,200,000.00 in funding.
  • The number of recipients for this funding is limited to 5 candidate(s).
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
  • Eligibility Category State governmentsCounty governmentsCity or township governmentsSpecial district governmentsIndependent school districtsPublic and State controlled institutions of higher educationNative American tribal governments (Federally recognized)Public housing authorities/Indian housing authoritiesNative American tribal organizations (other than Federally recognized tribal governments)Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher educationPrivate institutions of higher educationFor profit organizations other than small businessesSmall businessesOthers (see text field entitled Additional Information on Eligibility for clarification)The following types of Higher Education Institutions are always encouraged to apply for CDC support asPublic or Private Institutions of Higher EducationHispanic serving InstitutionsHistorically Black Colleges and Universities (HBCUs)Tribally Controlled Colleges and Universities (TCCUs)Alaska Native and Native Hawaiian Serving InstitutionsNonprofits Other Than Institutions of Higher EducationNonprofits (Other than Institutions of Higher Education)GovernmentsEligible Agencies of the Federal GovernmentU.S. Territory or PossessionOtherNative American tribal organizations (other than Federally recognized tribalgovernments)Faith based or Community based OrganizationsRegional OrganizationsBona Fide Agents a Bona Fide Agent is an agency/organization identified bythe state as eligible to submit an application under the state eligibility in lieu ofa state application. If applying as a bona fide agent of a state or localgovernment, a legal, binding agreement from the state or local government asdocumentation of the status is required. Attach with Other AttachmentForms when submitting via www.grants.gov.Federally Funded Research and Development Centers (FFRDCs) FFRDCsare operated, managed, and/or administered by a university or consortium ofuniversities, other not for profit or nonprofit organization, or an industrialfirm, as an autonomous organization or as an identifiable separate operatingunit of a parent organization. A FFRDC meets some special long termresearch or development need which cannot be met as effectively by anagencys existing in house or contractor resources. FFRDCs enable agenciesto use private sector resources to accomplish tasks that are integral to themission and operation of the sponsoring agency. For more information onFFRDCs, go to http:// ecfr.gpoaccess.gov /cgi/t/text/ text idxcecfrsid512ff78311f427c00454772dcf21523argndiv8viewtextnode481.0.1.6.34.0.1.18 idno482. Foreign OrganizationsForeign Organizations are not eligible to apply.Foreign components of U.S. Organizations are not eligible to apply.3. Special Eligibility RequirementsInstitutions/organizations that receive funds under Epi Centers for the Prevention of Healthcare Associated Infections, Antimicrobial Resistance and Adverse Events (U54) FOA CK11 001 are not eligible to apply.
Apply for RFA CK 15 004

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Opportunity Summary:

The grant opportunity titled "Epicenters for the Prevention of Healthcare Associated Infections (HAI) Cycle II" (Funding Opportunity Number RFA CK 15 004) is a CDC discretionary funding program offered as a cooperative agreement, meaning awardees would be expected to work closely with CDC in carrying out the project goals rather than operating in a fully independent, no-contact model. The overall purpose is to expand the CDC Prevention Epicenters network and push research findings into practical, real-world strategies that reduce healthcare-associated transmission risks, with a particular focus on Ebola and other infectious pathogens (viral or bacterial) that spread through mechanisms similar to Ebola. In plain terms, the program is designed to help turn laboratory, epidemiologic, and technological advances into prevention approaches that can actually be used in healthcare settings to better protect patients and healthcare workers.

A central theme of the opportunity is improving infection prevention and control at the point where transmission risk is highest: direct patient care and the immediate healthcare environment. The FOA highlights examples of the kinds of projects CDC is interested in supporting, including studies on how effective personal protective equipment (PPE) is against Ebola-like transmission risks, how and when healthcare workers may inadvertently contaminate themselves (for example, during donning and doffing), and how the built environment and surfaces in healthcare facilities can contribute to pathogen persistence and spread. The scope is intentionally broad enough to include multiple scientific angles, such as basic microbiology and virology, applied clinical epidemiology, human factors and workflow, environmental contamination and cleaning technologies, and other technologic innovations that can be implemented and evaluated in healthcare settings.

Financially, the CDC anticipated making about five awards under this announcement, with an estimated total funding amount of $11,000,000. Individual awards were expected to fall between an award floor of $1,500,000 and an award ceiling of $2,200,000. There was no cost-sharing or matching requirement, which typically lowers barriers to entry for applicants that may not have large pools of unrestricted funds to contribute. The program was categorized under a health activity area and aligned with CFDA number 93.823, associated with Ebola support, transmission prevention and control, public health preparedness, and related areas such as vaccine development, reflecting the broader preparedness and response context driving the work.

Eligibility for the program was expansive across U.S.-based organizations, spanning many government and non-government entities. Eligible applicants included state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing and Indian housing authorities; nonprofits with 501(c)(3) status (including those other than institutions of higher education); for-profit organizations (other than small businesses) as well as small businesses; eligible federal agencies; U.S. territories or possessions; faith-based and community-based organizations; regional organizations; and Federally Funded Research and Development Centers (FFRDCs). The FOA also allowed applications from bona fide agents applying on behalf of state or local governments, provided the applicant could supply a formal, legally binding agreement documenting that status. At the same time, there were clear exclusions: foreign organizations were not eligible, foreign components of U.S. organizations were not eligible, and institutions/organizations that already received funds under the earlier Epicenters FOA CK11 001 (U54) covering HAI, antimicrobial resistance, and adverse events were specifically prohibited from applying under this cycle, which suggests the CDC wanted to broaden participation rather than renew the same funded centers.

In terms of timing, the opportunity was posted on April 1, 2015, and the application closing date was June 1, 2015 (with an archive date of July 1, 2015). The administering agency was the Centers for Disease Control and Prevention. For applicants needing access support for the full announcement, the listed contact point was the CDC Procurement and Grants Technical Information Management Section at pgotim@cdc.gov.

Overall, this FOA can be understood as a targeted investment in applied, prevention-focused research capacity: building and expanding a network of "epicenters" capable of rapidly generating evidence and translating it into practical infection control strategies. Its emphasis on Ebola and similar transmission pathways reflects a preparedness mindset, but the real operational goal is broader: reducing healthcare-associated infections by improving PPE performance and use, minimizing healthcare worker self-contamination, and addressing environmental and systems factors that allow dangerous pathogens to spread inside healthcare facilities.

Frequently Asked Questions (FAQs)

What is the official title of this grant opportunity?

The opportunity is titled "Epicenters for the Prevention of Healthcare Associated Infections (HAI) Cycle II."

What is the Funding Opportunity Number (FON)?

The Funding Opportunity Number is RFA CK 15 004.

Which federal agency is offering this funding opportunity?

The administering agency is the Centers for Disease Control and Prevention (CDC).

What type of award is this?

This is a CDC discretionary funding program offered as a cooperative agreement.

What does "cooperative agreement" mean in this context?

A cooperative agreement means awardees are expected to work closely with CDC in carrying out the project goals, rather than operating in a fully independent model.

What is the main purpose of this program?

The overall purpose is to expand the CDC Prevention Epicenters network and move research findings into practical, real-world strategies that reduce healthcare-associated transmission risks, with particular focus on Ebola and other infectious pathogens that spread through mechanisms similar to Ebola.

What kinds of infections or pathogens are emphasized?

The FOA particularly emphasizes Ebola and other viral or bacterial pathogens that spread through transmission mechanisms similar to Ebola, within the broader goal of reducing healthcare-associated infections (HAIs).

What is the practical focus of the work being supported?

The FOA focuses on infection prevention and control at the point where transmission risk is highest: direct patient care and the immediate healthcare environment.

What are examples of projects CDC is interested in supporting?

Examples highlighted include studies on the effectiveness of personal protective equipment (PPE) against Ebola-like transmission risks, research on how and when healthcare workers may inadvertently contaminate themselves (including during donning and doffing), and studies on how the built environment and surfaces in healthcare facilities contribute to pathogen persistence and spread.

Is the scope limited to one scientific discipline?

No. The scope is intentionally broad and may include basic microbiology and virology, applied clinical epidemiology, human factors and workflow, environmental contamination and cleaning technologies, and other technologic innovations that can be implemented and evaluated in healthcare settings.

How many awards did CDC anticipate making?

CDC anticipated making about five awards under this announcement.

What was the estimated total funding amount for this opportunity?

The estimated total funding amount was $11,000,000.

What was the expected award size per recipient?

Individual awards were expected to range from an award floor of $1,500,000 to an award ceiling of $2,200,000.

Is cost sharing or matching required?

No. There was no cost-sharing or matching requirement.

What is the CFDA number associated with this program?

The program is aligned with CFDA number 93.823.

What health activity area or themes does this program align with?

It was categorized under a health activity area and associated with Ebola support, transmission prevention and control, public health preparedness, and related areas such as vaccine development, reflecting a broader preparedness and response context.

Who is eligible to apply?

Eligibility was expansive across U.S.-based organizations, including state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing and Indian housing authorities; nonprofits with 501(c)(3) status (including those other than institutions of higher education); for-profit organizations (other than small businesses) as well as small businesses; eligible federal agencies; U.S. territories or possessions; faith-based and community-based organizations; regional organizations; and Federally Funded Research and Development Centers (FFRDCs).

Can a bona fide agent apply on behalf of a state or local government?

Yes. The FOA allowed applications from bona fide agents applying on behalf of state or local governments, provided the applicant could supply a formal, legally binding agreement documenting that status.

Are foreign organizations eligible to apply?

No. Foreign organizations were not eligible.

Are foreign components of U.S. organizations eligible?

No. Foreign components of U.S. organizations were not eligible.

Are any organizations specifically prohibited from applying?

Yes. Institutions/organizations that already received funds under the earlier Epicenters FOA CK11 001 (U54) covering HAI, antimicrobial resistance, and adverse events were specifically prohibited from applying under this cycle.

Why were prior CK11 001 awardees prohibited from applying?

The FOA indicates this restriction, and it suggests CDC wanted to broaden participation rather than renew the same funded centers.

When was the opportunity posted?

The opportunity was posted on April 1, 2015.

What was the application due date?

The application closing date was June 1, 2015.

When was the opportunity archived?

The archive date was July 1, 2015.

What is the core idea behind "Prevention Epicenters" in this FOA?

This FOA represents a targeted investment in applied, prevention-focused research capacity by building and expanding a network of epicenters that can rapidly generate evidence and translate it into practical infection control strategies for healthcare settings.

How does this FOA connect Ebola preparedness to routine infection control?

While Ebola and similar transmission pathways are emphasized, the operational goal is broader: reducing healthcare-associated infections by improving PPE performance and use, minimizing healthcare worker self-contamination, and addressing environmental and systems factors that allow dangerous pathogens to spread inside healthcare facilities.

Who is the contact for access support for the full announcement?

The listed contact point for access support was the CDC Procurement and Grants Technical Information Management Section at pgotim@cdc.gov.

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