Opportunity Information: Apply for PA 15 001

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Epidemiology of Drug Abuse (R21)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
  • This funding opportunity was created on Oct 3, 2014 and posted on Oct 3, 2014.
  • Applicants must submit their applications by Sep 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $275,000.00 in funding.
  • Eligible applicants include: Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses State governments Public and State controlled institutions of higher education Special district governments County governments City or township governments Native American tribal governments (Federally recognized) For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The Epidemiology of Drug Abuse (R21) opportunity (Funding Opportunity Number PA 15-001) is a discretionary NIH grant program designed to fund exploratory or developmental research that deepens what is known about drug use, drug abuse, and addiction from an epidemiologic perspective. The central aim is to improve understanding of the nature and scope of substance use problems, how they are distributed across populations and settings, what causes or contributes to them (etiology), what conditions commonly co-occur with them (comorbidities), and what downstream effects they have on health and functioning. The program is explicitly interested in how these issues play out across multiple social levels, including individuals, families, peer networks, schools, workplaces, neighborhoods, communities, and diverse population groups, with an emphasis on generating knowledge that can ultimately strengthen prevention and treatment efforts and improve public health.

A key feature of this FOA is its encouragement of research that reflects the full breadth of modern epidemiology, meaning projects are expected to look beyond a single risk factor or a single disciplinary lens. Competitive applications are encouraged to integrate multiple levels of risk, resilience, and causation, and to draw on different scientific disciplines where appropriate. The announcement highlights interest in novel methods and approaches that can better capture the interplay among genetic, environmental, and developmental influences, as well as the relationships between social environments and health or disease outcomes tied to substance use. In practical terms, this can include work that tests new analytic strategies, leverages emerging data sources, combines biological and social measures, or develops clearer models of how various exposures and life-course processes shape substance use initiation, escalation, dependence, remission, relapse, and related harms.

The FOA also emphasizes making strong use of existing investments and data resources supported by NIH and other HHS agencies. That means proposals that responsibly and creatively harness existing datasets, cohorts, surveillance systems, or linked administrative data to answer important epidemiologic questions are particularly aligned with the stated goals. The intention is to accelerate progress by building on what has already been collected, while still pushing the science forward through innovative questions, improved measurement, refined causal inference strategies, or better characterization of high-risk and underserved populations. Ultimately, the expected payoff is evidence that can inform or improve public health prevention strategies and treatment programs, including by identifying modifiable risk and protective factors, clarifying trajectories and points of intervention, and improving understanding of who is most affected and why.

From an administrative standpoint, this is an R21 mechanism, which typically supports early-stage, high-impact, or methodologically innovative projects rather than large, long-term studies. The award ceiling listed for this opportunity is $275,000, and there is no cost sharing or matching requirement. The FOA was posted on October 3, 2014, and the final closing date was September 7, 2017, after which it was archived on October 8, 2017. The CFDA number associated with the program is 93.279 (Drug Abuse and Addiction Research Programs), and the sponsoring agency is the National Institutes of Health.

Eligibility is broad and includes a wide range of domestic applicants such as public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) entities), small businesses, other for-profit organizations (excluding small businesses in the separate category), and multiple levels of government (state, county, city/township, special district), as well as public housing authorities/Indian housing authorities and independent school districts. The FOA also lists many additional eligible applicant types, including faith-based and community-based organizations; minority-serving institutions such as HBCUs, Hispanic-serving institutions, AANAPISISs, Alaska Native and Native Hawaiian Serving Institutions, and Tribally Controlled Colleges and Universities; tribal governments and tribal organizations (including some categories beyond federally recognized tribes); regional organizations; and U.S. territories or possessions. Importantly, non-U.S. entities are eligible to apply, including foreign organizations and foreign institutions, and foreign components of U.S. organizations are allowed as defined under NIH policy.

For further details, the full announcement is referenced at http://grants.nih.gov/grants/guide/pa-files/PA-15-001.html, and the NIH Office of Extramural Research (OER) webmaster contact is provided for access or technical linking issues (FBOWebmaster@OD.NIH.GOV).

Frequently Asked Questions (FAQs): Epidemiology of Drug Abuse (R21) - PA 15-001

What is the Epidemiology of Drug Abuse (R21) funding opportunity (PA 15-001)?

PA 15-001 is a discretionary NIH grant opportunity that supports exploratory or developmental research focused on drug use, drug abuse, and addiction from an epidemiologic perspective. It is intended to deepen understanding of the nature, scope, causes, distribution, and consequences of substance use problems to ultimately strengthen prevention and treatment efforts and improve public health.

Which agency sponsors this program?

The sponsoring agency is the National Institutes of Health (NIH).

What does the R21 mechanism indicate about the type of research expected?

This opportunity uses the R21 mechanism, which typically supports early-stage, exploratory, high-impact, or methodologically innovative projects rather than large, long-term studies.

What is the central aim of this FOA?

The central aim is to improve understanding of substance use problems by examining: how common they are and how they are distributed across populations and settings; what causes or contributes to them (etiology); what conditions commonly co-occur with them (comorbidities); and what downstream effects they have on health and functioning.

What kinds of research questions are encouraged?

Applications are encouraged to address epidemiologic questions about substance use initiation, escalation, dependence, remission, relapse, and related harms, including identifying modifiable risk and protective factors, clarifying trajectories over time, and pinpointing potential points of intervention.

Does the FOA emphasize multi-level or multi-disciplinary approaches?

Yes. A key feature is the encouragement of research reflecting the full breadth of modern epidemiology. Competitive applications are expected to look beyond a single risk factor or disciplinary lens and instead integrate multiple levels of risk, resilience, and causation, drawing on different scientific disciplines as appropriate.

What social levels or settings does the FOA highlight?

The FOA explicitly highlights multiple social levels, including individuals, families, peer networks, schools, workplaces, neighborhoods, communities, and diverse population groups.

What types of methods or approaches are considered aligned with the FOA?

The FOA highlights interest in novel methods and approaches that capture the interplay among genetic, environmental, and developmental influences, and the relationships between social environments and substance use-related health or disease outcomes. Examples mentioned include testing new analytic strategies, leveraging emerging data sources, combining biological and social measures, and developing clearer models of life-course processes shaping substance use outcomes.

Is the FOA interested in research on genetic, environmental, and developmental influences?

Yes. The announcement specifically notes interest in approaches that better capture how genetic, environmental, and developmental influences interact, as well as how social environments relate to health or disease outcomes tied to substance use.

Does this opportunity encourage the use of existing datasets or data resources?

Yes. The FOA emphasizes making strong use of existing investments and data resources supported by NIH and other HHS agencies. Proposals that responsibly and creatively harness existing datasets, cohorts, surveillance systems, or linked administrative data are described as particularly aligned with the stated goals.

Is using existing data the only focus, or is innovation still expected?

Innovation is still expected. The FOA frames the use of existing data resources as a way to accelerate progress while pushing the science forward through innovative questions, improved measurement, refined causal inference strategies, or better characterization of high-risk and underserved populations.

What is the maximum award amount for this opportunity?

The award ceiling listed for this opportunity is $275,000.

Is cost sharing or matching required?

No. The FOA states there is no cost sharing or matching requirement.

When was the FOA posted, and what is its current status?

The FOA was posted on October 3, 2014. The final closing date was September 7, 2017, after which it was archived on October 8, 2017.

What is the Funding Opportunity Number?

The Funding Opportunity Number is PA 15-001.

What CFDA number is associated with this program?

The CFDA number associated with the program is 93.279 (Drug Abuse and Addiction Research Programs).

Who is eligible to apply?

Eligibility is broad. The FOA lists eligible applicants including: public and private institutions of higher education; nonprofits (including 501(c)(3) and certain non-501(c)(3) entities); small businesses; other for-profit organizations (excluding small businesses in the separate category); and multiple levels of government (state, county, city/township, special district). It also includes public housing authorities/Indian housing authorities and independent school districts.

Are faith-based and community-based organizations eligible?

Yes. The FOA explicitly lists faith-based and community-based organizations among eligible applicants.

Are minority-serving institutions eligible?

Yes. The FOA lists multiple minority-serving institution categories, including HBCUs, Hispanic-serving institutions, AANAPISISs, Alaska Native and Native Hawaiian Serving Institutions, and Tribally Controlled Colleges and Universities.

Are tribal governments and tribal organizations eligible?

Yes. The FOA lists tribal governments and tribal organizations as eligible applicants, including some categories beyond federally recognized tribes.

Are U.S. territories or possessions eligible to apply?

Yes. The FOA includes U.S. territories or possessions among eligible applicant types.

Can non-U.S. entities apply?

Yes. The FOA states that non-U.S. entities are eligible to apply, including foreign organizations and foreign institutions.

Are foreign components of U.S. organizations allowed?

Yes. Foreign components of U.S. organizations are allowed as defined under NIH policy.

What kinds of public health impacts does the FOA aim to support?

The FOA anticipates that funded research will generate evidence to inform or improve public health prevention strategies and treatment programs, including by identifying modifiable risk and protective factors, clarifying trajectories and intervention points, and improving understanding of who is most affected and why.

Where can applicants find the full announcement?

The full announcement is referenced at: http://grants.nih.gov/grants/guide/pa-files/PA-15-001.html

Who should be contacted for access or technical linking issues related to the announcement?

The NIH Office of Extramural Research (OER) webmaster contact is provided for access or technical linking issues: FBOWebmaster@OD.NIH.GOV

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