Epigenetic Processes in Development (R21) | Apply Online

Opportunity Summary:

The Epigenetic Processes in Development (R21) funding opportunity (RFA-HD-09-033) is a National Institutes of Health grant announcement issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). It invites exploratory, early-stage research projects that examine how epigenetic processes shape development across critical windows of the life course, including embryonic and fetal development, childhood, adolescence, and reproductive development. The central idea is to support studies that can clarify how epigenetic regulation contributes to normal developmental progression and how disruptions in those processes may be linked to pathological or perturbed development in areas aligned with NICHD mission priorities.

Projects are expected to focus specifically on epigenetic mechanisms or measurable changes in epigenetic marks that are tied to developmental milestones. This includes work aimed at identifying epigenetic changes that accompany a milestone, testing whether epigenetic changes help cause a milestone to occur, or exploring how attaining a milestone might itself lead to downstream epigenetic remodeling. The announcement also encourages study designs that compare epigenetic states across distinct developmental stages (for example, earlier versus later stages) or that contrast normal development with perturbed development at the same stage, with the goal of pinpointing plausible epigenetic mechanisms that underlie typical developmental processes.

The award mechanism is the NIH Exploratory/Developmental Research Grant (R21), which is generally intended for innovative, higher-risk concepts, pilot studies, or emerging research directions where preliminary data may be limited but the potential payoff is significant. For this specific FOA, NICHD indicated an intention to commit approximately $1.2 million in total costs in fiscal year 2010 and anticipated making up to six awards. The listed award ceiling is $200,000, reflecting the capped nature of this R21 competition.

Eligibility is broad and includes many types of applicant organizations. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), small businesses, and for-profit entities other than small businesses. Government entities at multiple levels are also eligible, including state governments, county governments, city or township governments, special district governments, and independent school districts, as well as public housing authorities/Indian housing authorities. The FOA further notes eligibility for tribal governments and tribal organizations, including federally recognized Native American tribal governments and other tribal entities. Additional eligible applicant categories explicitly include Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible agencies of the federal government, U.S. territories or possessions, regional organizations, and non-U.S. entities (foreign organizations). There is no cost sharing or matching requirement.

Administratively, the opportunity is categorized as a discretionary grant in the Health, Income Security, and Social Services funding activity area, associated with CFDA number 93.865 (Child Health and Human Development Extramural Research). It was posted on August 20, 2009, with an original and current closing date of November 18, 2009, and an archive date of December 19, 2009. The full announcement was made available through the NIH Grants Guide at the provided link (http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-09-033.html), and general technical support contacts were routed through the NIH Office of Extramural Research webmaster email addresses listed in the notice.

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