Opportunity Information: Apply for RFA MH 11 030
Apply for RFA MH 11 030
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Epigenomic Modifications in Neurodevelopment (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
- This funding opportunity was created on Jul 13, 2010 and posted on Jul 13, 2010.
- Applicants must submit their applications by Oct 20, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $5,000,000.00 to eligible and selected applicants.
- Eligible applicants include: City or township governments Public and State controlled institutions of higher education Private institutions of higher education State governments Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities For profit organizations other than small businesses County governments Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Epigenomic Modifications in Neurodevelopment (R01) opportunity (Funding Opportunity Number RFA-MH-11-030) was a National Institute of Mental Health (NIMH), National Institutes of Health (NIH) research grant program focused on how epigenetic and epigenomic changes shape brain development and, in turn, influence risk for mental disorders. At its core, the announcement called for projects that either (1) characterize specific epigenetic events that occur during neurodevelopmental processes or (2) identify epigenome-wide marks linked to early environmental exposures and later vulnerability to psychiatric illness. In other words, the program was aimed at connecting the biology of gene regulation (beyond DNA sequence) with developmental timing, environmental influence, and mental health outcomes.
A major scientific emphasis was on capturing complexity and biological variation. NIMH highlighted particular interest in studies that compare findings across species (for example, integrating human data with animal models to strengthen causal interpretation) and studies that directly address heterogeneity in epigenetic marks across different tissue types. This included a strong interest in cell-type specificity in the brain and how epigenomic signatures change across developmental stages. That framing makes clear the program was not looking for one-size-fits-all epigenetic conclusions, but rather for designs that can distinguish which marks occur in which cells, in which brain regions or tissues, and at which points in development.
The award mechanism for this announcement was the NIH Research Project Grant (R01), which typically supports more mature, hypothesis-driven projects with a substantial scope of work. This R01 announcement ran in parallel with a companion FOA of the same scientific scope, RFA-MH-11-031, which used the Exploratory/Developmental Grant (R21) mechanism for earlier-stage or higher-risk exploratory work. Together, these paired announcements were structured to support both established lines of investigation (R01) and more preliminary, proof-of-concept efforts (R21), while keeping the scientific priorities aligned.
In terms of funding scale, NIMH indicated an intention to commit about $5,000,000 in total costs in fiscal year 2011 to support 10 or more combined awards across the R01 and R21 programs responding to this FOA and its companion announcement. This language signals that the $5 million was a pooled estimate across both mechanisms rather than a guarantee for the R01 alone, and that the final number of awards would depend on application quality, program priorities, and available funds.
Eligibility was broad and included many organization types. Eligible applicants listed for this opportunity included public and private institutions of higher education, state and local governments (including city, county, township, and special district governments), nonprofit organizations both with and without 501(c)(3) status (with certain categories noted), small businesses and other for-profit organizations (with distinctions for small businesses), public and Indian housing authorities, independent school districts, and a wide range of tribal entities including federally recognized tribal governments and other tribal organizations. The eligibility section also explicitly referenced additional categories such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, U.S. territories or possessions, and non-U.S. (foreign) entities and regional organizations. The announcement also stated there was no cost sharing or matching requirement, which is consistent with many NIH research grant programs.
Administratively, this was a discretionary grant in the health funding activity category, under CFDA 93.242 (Mental Health Research Grants). The opportunity was posted and created on July 13, 2010, with an original (and final) application closing date of October 20, 2010, and it was archived on November 20, 2010. Applicants were directed to the full FOA text via the NIH Grants Guide link (http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-11-030.html), with NIH Office of Extramural Research (OER) webmaster contacts provided for access or linking issues.
Overall, this FOA was designed to push forward rigorous, developmentally informed epigenomics research tied to psychiatric risk, with special attention to cross-species validation and to the reality that epigenetic regulation varies dramatically by tissue, brain cell type, and developmental window.
Frequently Asked Questions (FAQs)
What is the Epigenomic Modifications in Neurodevelopment (R01) funding opportunity?
The Epigenomic Modifications in Neurodevelopment (R01) opportunity (Funding Opportunity Number RFA-MH-11-030) was a National Institute of Mental Health (NIMH), National Institutes of Health (NIH) research grant program focused on how epigenetic and epigenomic changes shape brain development and influence risk for mental disorders.
What kinds of research projects did this FOA seek to support?
The announcement called for projects that either (1) characterize specific epigenetic events occurring during neurodevelopmental processes or (2) identify epigenome-wide marks associated with early environmental exposures and later vulnerability to psychiatric illness.
What is the core scientific goal of this program?
The core goal was to connect gene regulation beyond DNA sequence (epigenetics/epigenomics) with developmental timing, environmental influences, and mental health outcomes, particularly psychiatric risk.
Did the FOA emphasize specific study design considerations?
Yes. A major emphasis was on capturing complexity and biological variation, including interest in cross-species comparisons and in directly addressing heterogeneity in epigenetic marks across different tissue types.
Was cross-species research encouraged?
Yes. NIMH highlighted particular interest in studies that compare findings across species, such as integrating human data with animal models to strengthen causal interpretation.
Did the FOA prioritize tissue-specific or cell-type-specific epigenomic analysis?
Yes. The program showed strong interest in heterogeneity across tissue types, including cell-type specificity in the brain and how epigenomic signatures change across developmental stages.
What award mechanism was used for this opportunity?
This FOA used the NIH Research Project Grant (R01) mechanism, which typically supports more mature, hypothesis-driven projects with a substantial scope of work.
Was there a related or companion funding opportunity?
Yes. This R01 announcement ran in parallel with a companion FOA, RFA-MH-11-031, which used the Exploratory/Developmental Grant (R21) mechanism while sharing the same scientific scope and priorities.
How were the R01 and R21 announcements positioned relative to each other?
Together, the paired announcements were structured to support both established lines of investigation (R01) and earlier-stage or higher-risk exploratory efforts (R21), while keeping scientific priorities aligned.
How much funding did NIMH plan to commit to these programs?
NIMH indicated an intention to commit about $5,000,000 in total costs in fiscal year 2011 to support 10 or more combined awards across the R01 and R21 programs responding to this FOA and its companion announcement.
Was the stated $5 million budget specific to the R01 mechanism alone?
No. The FOA language indicates the approximately $5,000,000 was a pooled estimate across both the R01 and R21 mechanisms rather than a guarantee for the R01 program alone.
How many awards were expected to be made?
NIMH anticipated 10 or more combined awards across the R01 and R21 programs, with the final number depending on application quality, program priorities, and available funds.
Who was eligible to apply?
Eligibility was broad and included public and private institutions of higher education; state and local governments (including city, county, township, and special district governments); nonprofit organizations with or without 501(c)(3) status (with certain categories noted); small businesses and other for-profit organizations (with distinctions for small businesses); public and Indian housing authorities; independent school districts; and tribal entities including federally recognized tribal governments and other tribal organizations.
Did the FOA include eligibility for specific institution types such as HBCUs and Hispanic-serving Institutions?
Yes. The eligibility section explicitly referenced categories including Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs), among others.
Were faith-based or community-based organizations eligible?
Yes. The eligibility language included faith-based or community-based organizations.
Could non-U.S. (foreign) entities apply?
Yes. The eligibility section referenced non-U.S. (foreign) entities and regional organizations.
Were U.S. territories or possessions included in the eligibility list?
Yes. The eligibility section explicitly referenced U.S. territories or possessions.
Was cost sharing or matching required?
No. The announcement stated there was no cost sharing or matching requirement.
What type of grant was this classified as?
Administratively, it was a discretionary grant in the health funding activity category.
What CFDA number was associated with this opportunity?
The opportunity was listed under CFDA 93.242 (Mental Health Research Grants).
When was this funding opportunity posted?
The opportunity was posted and created on July 13, 2010.
What was the application deadline?
The original (and final) application closing date was October 20, 2010.
When was the FOA archived?
The opportunity was archived on November 20, 2010.
Where could applicants find the full FOA text?
Applicants were directed to the NIH Grants Guide FOA page at http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-11-030.html.
Who was listed for help with access or linking issues?
NIH Office of Extramural Research (OER) webmaster contacts were provided for access or linking issues.
What overall research direction did NIMH aim to advance through this FOA?
The FOA was designed to advance rigorous, developmentally informed epigenomics research tied to psychiatric risk, with special attention to cross-species validation and to variation by tissue, brain cell type, and developmental window.
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