Opportunity Information: Apply for RFA ES 10 002
Apply for RFA ES 10 002
- The National Institutes of Health in the education food and nutrition health income security and social services sector is offering a public funding opportunity titled "Epigenomics of Human Health and Disease (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research 93.173 Research Related to Deafness and Communication Disorders 93.213 Research and Training in Complementary and Integrative Health 93.233 National Center on Sleep Disorders Research 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.361 Nursing Research 93.393 Cancer Cause and Prevention Research 93.394 Cancer Detection and Diagnosis Research 93.395 Cancer Treatment Research 93.396 Cancer Biology Research 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research.
- This funding opportunity was created on Jul 7, 2010 and posted on Jul 7, 2010.
- Applicants must submit their applications by Sep 29, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $5,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education State governments Native American tribal governments (Federally recognized) County governments Public housing authorities/Indian housing authorities For profit organizations other than small businesses City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Private institutions of higher education Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
Epigenomics of Human Health and Disease (R01) is a National Institutes of Health (NIH) funding opportunity (RFA-ES-10-002) aimed at supporting highly innovative research that explains how epigenetic changes contribute to human disease. The central focus is on uncovering and characterizing epigenetic marks or features in relevant human cells and tissues, especially those that reflect particular disease states, conditions, or biological processes tied to disease. Projects are expected to go beyond simply cataloging changes by clarifying what those epigenetic signatures are, how they interact with one another, and why they matter in the context of health and pathology.
A major theme of the announcement is mechanistic insight. Applicants are encouraged to propose studies that investigate how epigenetic changes arise in diseased, stressed, or otherwise compromised states, and how those changes translate into measurable phenotypic differences. In practice, that could include work on DNA methylation patterns, histone modifications, chromatin accessibility, non-coding RNA related regulation, or integrated epigenomic features that help explain disease onset, progression, severity, or response to environmental exposures or other triggers. The FOA is positioned to support research that connects epigenomic variation to real biological outcomes, using disease-relevant tissues or models that closely mirror human conditions.
The funding mechanism is the NIH R01 research project grant, meaning it is intended for substantial, hypothesis-driven or discovery-driven projects with clear research plans and strong scientific justification. The participating agencies planned to commit approximately $6.7 million total, with awards dependent on available funds and the quality and number of applications received. The anticipated number of awards was listed as roughly 10 to 15, indicating a competitive program but one large enough to support a small cohort of diverse projects across disease areas and scientific approaches.
This opportunity was published in July 2010 (posted and created July 7, 2010) with an original and current closing date of September 29, 2010, and an archive date of October 30, 2010. While the listing includes an estimated total funding figure of $5,000,000 in one field, the FOA narrative states an intended commitment of $6.7 million; taken together, that suggests the program expected to support multiple awards but with final totals dependent on appropriations and award decisions.
Eligibility was broad and designed to include a wide range of research-performing organizations. Eligible applicants included public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, other than institutions of higher education), for-profit organizations other than small businesses, small businesses, and multiple levels of government (state, county, city/township, special district). The announcement also explicitly included tribal governments and tribal organizations, public housing authorities/Indian housing authorities, and allowed participation from non-U.S. entities (foreign organizations) and regional organizations. Additional eligible categories highlighted were HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, and U.S. territories or possessions. Cost sharing or matching was not required.
The program’s scope spans many health and disease areas reflected by the CFDA listings, covering topics such as cancer, cardiovascular and lung disease, neurological disorders, diabetes and kidney disease, arthritis and skin disease, aging, child health, sleep disorders, alcohol and drug abuse, nursing research, deafness and communication disorders, oral health, and complementary and integrative health. In other words, the FOA is not limited to a single disease category; it is meant to stimulate epigenomics-based discoveries across a wide biomedical landscape wherever epigenetic regulation may help explain disease mechanisms or clinically relevant variation.
For full details, NIH provided an official announcement link (http://grants.nih.gov/grants/guide/rfa_files/RFA-ES-10-002.html) and contacts through the NIH Office of Extramural Research (OER) webmaster for access or technical issues.
FAQs: Epigenomics of Human Health and Disease (R01) (RFA-ES-10-002)
What is the Epigenomics of Human Health and Disease (R01) funding opportunity?
Epigenomics of Human Health and Disease (R01) is a National Institutes of Health (NIH) funding opportunity announcement (FOA) that supports highly innovative research aimed at explaining how epigenetic changes contribute to human disease. The FOA emphasizes identifying and characterizing epigenetic marks or features in relevant human cells and tissues and clarifying why those signatures matter for health and pathology.
What is the FOA number for this opportunity?
The FOA number is RFA-ES-10-002.
Which NIH grant mechanism is used?
This opportunity uses the NIH R01 research project grant mechanism, intended for substantial projects with clear research plans and strong scientific justification.
What is the central scientific focus of the program?
The central focus is to uncover and characterize epigenetic marks or features in disease-relevant human cells and tissues, especially those reflecting specific disease states, conditions, or biological processes tied to disease.
Does the FOA want more than a catalog of epigenetic changes?
Yes. Projects are expected to go beyond simply cataloging changes. The FOA highlights the need to clarify what epigenetic signatures are, how they interact with one another, and why they matter in the context of disease and health.
What kind of insight does the FOA emphasize?
A major theme is mechanistic insight. Applicants are encouraged to study how epigenetic changes arise in diseased, stressed, or otherwise compromised states and how those changes translate into measurable phenotypic differences.
What types of epigenetic features are within scope?
The FOA indicates scope that can include DNA methylation patterns, histone modifications, chromatin accessibility, non-coding RNA-related regulation, or integrated epigenomic features that help explain disease onset, progression, severity, or responses to environmental exposures or other triggers.
Is the program limited to one disease area?
No. The FOA spans a broad range of health and disease areas and is intended to stimulate epigenomics-based discoveries across many biomedical domains where epigenetic regulation may explain disease mechanisms or clinically relevant variation.
What kinds of tissues or models are encouraged?
The FOA emphasizes using relevant human cells and tissues and supporting research that connects epigenomic variation to real biological outcomes using disease-relevant tissues or models that closely mirror human conditions.
How much funding was NIH planning to commit?
The FOA narrative states that participating agencies planned to commit approximately $6.7 million total, with awards dependent on available funds and the quality and number of applications received.
Why do different funding totals appear in the listing?
The information provided includes an estimated total funding figure of $5,000,000 in one field, while the FOA narrative states an intended commitment of $6.7 million. Taken together, this suggests the program expected multiple awards, with final totals dependent on appropriations and award decisions.
How many awards were anticipated?
The anticipated number of awards was roughly 10 to 15.
When was the opportunity posted?
The opportunity was published in July 2010 and was posted/created on July 7, 2010.
What was the closing date for applications?
The original and current closing date listed was September 29, 2010.
Is this FOA still active?
Based on the information provided, it was archived on October 30, 2010, and the closing date was September 29, 2010.
Who is eligible to apply?
Eligibility was broad and included many types of research-performing organizations, including public and private institutions of higher education; nonprofit organizations (with and without 501(c)(3) status, other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and various levels of government (state, county, city/township, special district).
Are tribal entities eligible?
Yes. The FOA explicitly included tribal governments and tribal organizations.
Are foreign (non-U.S.) entities eligible?
Yes. The announcement allowed participation from non-U.S. entities (foreign organizations) and regional organizations.
Are U.S. territories or possessions included in eligible applicant categories?
Yes. U.S. territories or possessions were highlighted among eligible categories.
Are minority-serving institutions specifically included?
Yes. The eligible categories highlighted included HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based and community-based organizations were explicitly listed among eligible categories.
Are public housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities were included in the eligibility list.
Is cost sharing or matching required?
No. Cost sharing or matching was not required.
What health topics does the FOA broadly cover?
The scope aligns with many NIH-related health areas reflected by the CFDA listings, including (as examples provided) cancer; cardiovascular and lung disease; neurological disorders; diabetes and kidney disease; arthritis and skin disease; aging; child health; sleep disorders; alcohol and drug abuse; nursing research; deafness and communication disorders; oral health; and complementary and integrative health.
Where can applicants find the official announcement?
NIH provided an official announcement link: http://grants.nih.gov/grants/guide/rfa_files/RFA-ES-10-002.html
Who should be contacted for access or technical issues related to the announcement?
The information provided points to contacts through the NIH Office of Extramural Research (OER) webmaster for access or technical issues.
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