Opportunity Information: Apply for PA 13 034
Apply for PA 13 034
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Erythropoiesis Components and Mechanisms (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.839 Blood Diseases and Resources Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Dec 5, 2012 and posted on Dec 5, 2012.
- Applicants must submit their applications by Jan 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Special district governments Private institutions of higher education Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education City or township governments Public housing authorities/Indian housing authorities State governments Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Erythropoiesis Components and Mechanisms (R01) funding opportunity (PA 13 034) was a National Institutes of Health research grant program led by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) in partnership with the National Heart, Lung, and Blood Institute (NHLBI). It invited investigator-initiated, hypothesis-driven R01 applications focused specifically on erythroid cells and the biological process of erythropoiesis, meaning the production and maturation of red blood cells. The central purpose was to push the field toward a more complete, integrated description of the molecular and cellular machinery that builds and regulates the erythroid lineage across development and differentiation.
Scientifically, the FOA emphasized identifying and characterizing the "components" that make erythropoiesis work and explaining how those components contribute mechanistically to normal red blood cell formation. It highlighted two major classes of components. The first is the set of genes expressed in erythroid cells (the transcriptome), including genes that turn on and off during developmental stages or along differentiation trajectories. The second is the set of proteins produced in erythroid cells (the proteome), with a particular interest in proteins whose behavior is uniquely erythroid, such as those with distinctive post-translational modifications or subcellular localization patterns. In other words, the program was looking for research that does not just catalog molecules, but links gene and protein activity to functional outcomes in erythroid biology.
A key long-range goal described in the announcement was to unify multiple layers of understanding into a concise, coherent framework for erythropoiesis. That includes integrating genetics, core molecular processes, and cytokine-driven determinants (signals and growth factors that influence erythroid survival, proliferation, and maturation). The practical motivation behind this systems-level understanding was translational: by clarifying how erythropoiesis is organized and controlled, the program aimed to lay groundwork for new ways to measure, prevent, and treat anemia and related blood disorders. While the FOA was not limited to any single disease area, it framed anemia as an important downstream clinical target that could benefit from deeper mechanistic insight.
From an administrative and eligibility standpoint, this was a discretionary grant mechanism using the NIH R01 funding instrument. It carried no cost-sharing or matching requirement. Eligibility was broad and included many U.S. governmental entities (state, county, city/township), public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, other than institutions of higher education), public housing authorities/Indian housing authorities, independent school districts, tribal governments and tribal organizations, and for-profit organizations (including small businesses and other for-profits). The announcement also explicitly allowed non-U.S. participation: foreign organizations and foreign institutions were eligible to apply, non-U.S. components of U.S. organizations were eligible, and foreign components (as defined by NIH policy) were allowed. It also called out a range of institution types commonly referenced in federal funding language, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and Asian American/Native American/Pacific Islander-serving institutions, among others.
In terms of timing, the opportunity was posted and created on December 5, 2012, with an original and final listed closing date of January 7, 2016, and an archive date of February 7, 2016. The program was associated with NIH CFDA numbers 93.839 (Blood Diseases and Resources Research) and 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research). The full announcement was hosted on the NIH grants site, and technical access issues were routed to the NIH Office of Extramural Research webmaster contact provided in the notice.
Frequently Asked Questions (FAQs)
What is the "Erythropoiesis Components and Mechanisms (R01)" funding opportunity?
It was a National Institutes of Health (NIH) research grant opportunity titled "Erythropoiesis Components and Mechanisms (R01)" under FOA number PA 13 034. It supported investigator-initiated, hypothesis-driven R01 applications focused on erythroid cells and the biological process of erythropoiesis (the production and maturation of red blood cells).
Which NIH Institutes led and partnered on this program?
The program was led by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) in partnership with the National Heart, Lung, and Blood Institute (NHLBI).
What grant mechanism was used?
This opportunity used the NIH R01 research project grant mechanism.
What was the central purpose of the FOA?
The purpose was to push the field toward a more complete, integrated description of the molecular and cellular machinery that builds and regulates the erythroid lineage across development and differentiation.
What scientific area did the FOA focus on?
The FOA focused specifically on erythroid cells and erythropoiesis, emphasizing research that identifies and characterizes the components that make erythropoiesis work and explains how those components contribute mechanistically to normal red blood cell formation.
What types of research applications were invited?
The FOA invited investigator-initiated, hypothesis-driven research applications. It emphasized studies that go beyond cataloging molecules by linking gene and protein activity to functional outcomes in erythroid biology.
What does the FOA mean by "components" of erythropoiesis?
The announcement highlighted two major classes of components: (1) genes expressed in erythroid cells (the transcriptome), including genes that turn on and off during developmental stages or along differentiation trajectories, and (2) proteins produced in erythroid cells (the proteome), with interest in proteins showing uniquely erythroid behaviors such as distinctive post-translational modifications or subcellular localization patterns.
Did the FOA only support transcriptomic or proteomic cataloging studies?
No. While it highlighted the transcriptome and proteome as key component classes, the program interest was in research that connects gene and protein activity to mechanisms and functional outcomes in erythroid biology, not only listing molecules.
What long-range scientific goal was described?
A key long-range goal was to unify multiple layers of understanding into a concise, coherent framework for erythropoiesis, integrating genetics, core molecular processes, and cytokine-driven determinants that influence erythroid survival, proliferation, and maturation.
How did the FOA connect basic research to clinical impact?
The FOA framed a practical translational motivation: by clarifying how erythropoiesis is organized and controlled, the program aimed to lay groundwork for new ways to measure, prevent, and treat anemia and related blood disorders.
Was the FOA limited to a single disease area?
No. The FOA was not limited to any single disease area, but it highlighted anemia as an important downstream clinical target that could benefit from deeper mechanistic insight.
Was cost sharing or matching required?
No. The opportunity carried no cost-sharing or matching requirement.
Who was eligible to apply?
Eligibility was broad and included many U.S. governmental entities (state, county, and city/township), public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, other than institutions of higher education), public housing authorities/Indian housing authorities, independent school districts, tribal governments and tribal organizations, and for-profit organizations (including small businesses and other for-profits).
Were foreign organizations allowed to apply?
Yes. The announcement explicitly allowed non-U.S. participation: foreign organizations and foreign institutions were eligible to apply, non-U.S. components of U.S. organizations were eligible, and foreign components (as defined by NIH policy) were allowed.
Did the eligibility language include specific institution categories like HBCUs and HSIs?
Yes. The opportunity called out a range of institution types commonly referenced in federal funding language, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and Asian American/Native American/Pacific Islander-serving institutions, among others.
When was this funding opportunity posted and created?
It was posted and created on December 5, 2012.
What was the closing date for applications?
The opportunity listed an original and final closing date of January 7, 2016.
When was the announcement archived?
The archive date was February 7, 2016.
What CFDA numbers were associated with this program?
The program was associated with NIH CFDA numbers 93.839 (Blood Diseases and Resources Research) and 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).
Where was the full announcement hosted?
The full announcement was hosted on the NIH grants site.
Who should be contacted for technical access issues?
Technical access issues were routed to the NIH Office of Extramural Research webmaster contact provided in the notice.
What does "investigator-initiated" mean in the context provided?
Within the information provided, "investigator-initiated" indicates the FOA invited applications proposed by investigators, centered on their hypotheses, rather than restricting proposals to a single predefined experimental plan.
What does "hypothesis-driven" imply for proposed projects under this FOA?
Based on the FOA description, it implies projects were expected to test specific scientific hypotheses about the genes, proteins, and mechanisms that build and regulate erythroid cells and erythropoiesis, with an emphasis on mechanistic links to function.
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