Opportunity Information: Apply for PAR 15 298

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Establishing Outcome Measures for Clinical Studies of Oral and Craniofacial Diseases and Conditions (R21)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research.
  • This funding opportunity was created on Jul 17, 2015 and posted on Jul 17, 2015.
  • Applicants must submit their applications by Sep 7, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $200,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) State governments Native American tribal governments (Federally recognized) Small businesses Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education For profit organizations other than small businesses City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Special district governments Private institutions of higher education County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

PAR 15-298, titled "Establishing Outcome Measures for Clinical Studies of Oral and Craniofacial Diseases and Conditions (R21)," is an NIH discretionary grant opportunity in the health area (CFDA 93.121, Oral Diseases and Disorders Research). The central purpose of the announcement is to fund early-stage, exploratory projects that create or strengthen outcome measures used in clinical studies involving people with oral and craniofacial diseases or related conditions. In practical terms, the program is aimed at improving the tools researchers use to judge whether an intervention works or how a condition changes over time, with a strong emphasis on making sure those tools are scientifically solid rather than ad hoc or inconsistently applied across studies.

The focus is on developing "well-founded" outcome measures and, critically, establishing key measurement properties such as reliability and validity. Reliability generally means the measure produces consistent results when it should (for example, agreement between raters or stability across repeated testing under similar conditions). Validity generally means the measure actually captures what it claims to measure (for example, that a score intended to reflect pain impact or functional limitation is truly reflecting that construct and not something unrelated). The intent is to support the kinds of careful methodological work that can be overlooked in clinical research, but that ultimately determines whether study findings are interpretable, comparable, and useful for patient care or future trials.

This opportunity uses the NIH R21 funding mechanism, which is typically used for exploratory or developmental research. The listing shows an estimated total funding amount of $200,000, with an award ceiling of $200,000, and it specifies that there is no cost sharing or matching requirement. The program was posted and created on July 17, 2015, with an original and current closing date of September 7, 2018, and an archive date of October 8, 2018, indicating that it is no longer active but remains available as a historical funding announcement.

A wide range of applicant organizations are eligible. Eligible applicants include public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), for-profit organizations (including small businesses and other for-profits), state and local governmental entities (such as state governments, counties, cities or townships, independent school districts, and special district governments), and certain housing authorities. The eligibility section also includes various mission-focused and community-based categories, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations, U.S. territories or possessions, and regional organizations. Federally recognized tribal governments are eligible, and tribal organizations that are not federally recognized are also listed among eligible entities.

There are important limits related to non-U.S. applicants. Non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations are explicitly not eligible to apply as applicant organizations. At the same time, the announcement indicates that foreign components may be allowed as defined in the NIH Grants Policy Statement, which generally means a U.S.-based applicant could potentially include certain foreign elements in the project when well-justified and compliant with NIH policy, even though a foreign institution could not be the primary applicant.

The sponsoring agency is the National Institutes of Health. The full announcement was made available through the NIH grants guide page associated with PAR 15-298 (the link provided in the source data). For technical issues accessing the notice or linking to it, the contact provided is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.

FAQs: PAR 15-298 - Establishing Outcome Measures for Clinical Studies of Oral and Craniofacial Diseases and Conditions (R21)

What is PAR 15-298?

PAR 15-298 is an NIH discretionary grant opportunity titled "Establishing Outcome Measures for Clinical Studies of Oral and Craniofacial Diseases and Conditions (R21)." It focuses on supporting research that develops or strengthens outcome measures used in clinical studies involving people with oral and craniofacial diseases or related conditions.

Which agency sponsors this opportunity?

The sponsoring agency is the National Institutes of Health (NIH).

What health area or program does this opportunity fall under?

This opportunity is in the health area and is associated with CFDA 93.121, Oral Diseases and Disorders Research.

What is the main purpose of this funding announcement?

The central purpose is to fund early-stage, exploratory projects that create or improve outcome measures used in clinical studies of oral and craniofacial diseases and conditions. The program emphasizes making outcome measures scientifically solid and more consistently applied across studies.

What kinds of projects are this program trying to support?

The program supports methodological work to develop "well-founded" outcome measures and to establish key measurement properties such as reliability and validity, so clinical study results are more interpretable, comparable, and useful.

What does the program mean by "outcome measures" in clinical studies?

Outcome measures are the tools, instruments, or metrics researchers use to judge whether an intervention works or how a condition changes over time in people participating in clinical studies.

Why is there an emphasis on developing "well-founded" outcome measures?

Because the quality of outcome measures often determines whether clinical study findings are interpretable and comparable. The announcement highlights that careful measurement development is sometimes overlooked, even though it is essential to producing usable evidence for patient care and future trials.

What measurement properties are specifically highlighted in this opportunity?

The announcement specifically emphasizes establishing reliability and validity for outcome measures.

What is reliability in the context of outcome measures?

Reliability generally means a measure produces consistent results when it should. Examples mentioned include agreement between raters and stability across repeated testing under similar conditions.

What is validity in the context of outcome measures?

Validity generally means the measure actually captures what it claims to measure. An example given is whether a score intended to reflect pain impact or functional limitation truly reflects that construct rather than something unrelated.

What funding mechanism is used for PAR 15-298?

This opportunity uses the NIH R21 mechanism, which is typically used for exploratory or developmental research.

How much funding is available under this opportunity?

The listing shows an estimated total funding amount of $200,000, with an award ceiling of $200,000.

Is cost sharing or matching required?

No. The opportunity specifies there is no cost sharing or matching requirement.

Is this grant opportunity still open?

No. The opportunity shows an original and current closing date of September 7, 2018, and an archive date of October 8, 2018, indicating it is no longer active and is available as a historical announcement.

When was this opportunity posted?

The opportunity was posted and created on July 17, 2015.

What types of organizations are eligible to apply?

A wide range of applicant organizations are eligible, including public and private institutions of higher education, nonprofits (with and without 501(c)(3) status), and for-profit organizations (including small businesses and other for-profits).

Are state and local governments eligible applicants?

Yes. The eligibility list includes state governments, counties, cities or townships, independent school districts, special district governments, and certain housing authorities.

Are minority-serving institutions included in the eligible applicant categories?

Yes. Eligible categories include Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).

Are faith-based or community-based organizations eligible?

Yes. The eligibility section includes faith-based or community-based organizations.

Are U.S. territories or possessions eligible?

Yes. U.S. territories or possessions are listed among eligible entities, along with regional organizations.

Are tribal governments eligible to apply?

Yes. Federally recognized tribal governments are eligible, and the eligibility list also includes tribal organizations that are not federally recognized.

Can a non-U.S. organization apply as the primary applicant?

No. Non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations are explicitly not eligible to apply as applicant organizations.

Are any foreign activities allowed at all under this announcement?

Possibly. While foreign entities cannot be the primary applicant, the announcement indicates that foreign components may be allowed as defined in the NIH Grants Policy Statement, meaning a U.S.-based applicant could potentially include foreign elements if they are well-justified and compliant with NIH policy.

Where can applicants find the full announcement?

The full announcement is available through the NIH grants guide page associated with PAR 15-298 (as referenced in the source information).

Who should be contacted for technical issues accessing the notice or linking to it?

For technical issues accessing the notice or linking to it, the contact listed is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.

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