Opportunity Information: Apply for RFA DE 17 001
Apply for RFA DE 17 001
- The HHS-NIH11 in the health sector is offering a public funding opportunity titled "Establishment of Resource Centers for Dental, Oral and Craniofacial Tissue Regeneration Consortium (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121,.
- This funding opportunity was created on Apr 05, 2016 and posted on Apr 05, 2016.
- Applicants must submit their applications by Jul 20, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $2,500,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The funding opportunity titled "Establishment of Resource Centers for Dental, Oral and Craniofacial Tissue Regeneration Consortium (U24)" is a National Institutes of Health (NIH) cooperative agreement designed to stand up multidisciplinary Resource Centers that will serve as the backbone for Stage 2 of the Dental, Oral and Craniofacial Tissue Regeneration Consortium (DOCTRC). The core idea is to move beyond earlier-stage team formation and proof-of-concept work from Stage 1 and, instead, build centralized capacity that can consistently support multiple projects and investigators. These Resource Centers are meant to integrate clinical expertise, foundational and translational science, industry know-how, and regulatory experience so that promising strategies for regenerating or reconstructing dental, oral, and craniofacial (DOC) tissues can be pushed more efficiently toward clinical testing.
Functionally, the Resource Centers are expected to provide shared technical support and research capacity, along with the administrative infrastructure needed to coordinate consortium activities. A major emphasis is on regulatory expertise, reflecting the reality that tissue regeneration strategies often face complex development pathways (for example, issues tied to manufacturing, quality control, and compliance expectations that come up when preparing for human trials). By consolidating these functions into dedicated centers, the consortium can reduce duplication of effort across individual research teams, standardize approaches where appropriate, and improve readiness to advance candidates into clinical trials. The FOA frames the centers as enablers: they do not simply fund isolated research projects, but rather establish an operational and expert resource that helps the entire consortium translate regenerative concepts into clinically viable interventions.
This announcement is listed as RFA DE 17 001 and uses the U24 activity mechanism, which is a cooperative agreement. That matters because it typically implies substantial NIH involvement in coordinating or guiding aspects of the program compared with a standard research grant. The activity category is health, and the associated CFDA numbers are 93.121. The sponsoring agency is identified as HHS-NIH11. The opportunity was created and posted on April 5, 2016, with an application closing date of July 20, 2016 (the original and current closing dates match).
In terms of who could apply, eligibility was broad and included many kinds of organizations and governments. Eligible applicants included state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations both with and without 501(c)(3) status (excluding institutions of higher education for those nonprofit categories as stated); for-profit organizations other than small businesses; small businesses; and other entities as described in the FOA's additional eligibility text. This wide eligibility reflects the multidisciplinary and translational nature of the work, where academic labs, clinical institutions, industry partners, and specialized organizations may all contribute meaningfully to a shared resource center model.
The award information provided includes an award ceiling of $2,500,000. The number of expected awards is not specified in the provided data. Overall, the FOA is aimed at building coordinated infrastructure and specialized support that can accelerate the progression of DOC tissue regeneration and reconstruction strategies from promising laboratory or preclinical efforts into the clinical trial pipeline, using the consortium model to integrate expertise and share resources across participating teams.
Frequently Asked Questions (FAQs)
What is the title of this funding opportunity?
The opportunity is titled "Establishment of Resource Centers for Dental, Oral and Craniofacial Tissue Regeneration Consortium (U24)."
Which agency is offering this opportunity?
The sponsoring agency is the National Institutes of Health (NIH), identified as HHS-NIH11.
What is the FOA number for this announcement?
The announcement is listed as RFA DE 17 001.
What type of funding mechanism is being used?
This opportunity uses the U24 activity mechanism, which is a cooperative agreement.
What does it mean that this is a cooperative agreement (U24)?
Because it is a cooperative agreement, it typically implies substantial NIH involvement in coordinating or guiding aspects of the program compared with a standard research grant.
What is the main purpose of the Resource Centers being proposed?
The purpose is to stand up multidisciplinary Resource Centers that serve as the backbone for Stage 2 of the Dental, Oral and Craniofacial Tissue Regeneration Consortium (DOCTRC), providing centralized capacity to support multiple projects and investigators.
How does Stage 2 differ from Stage 1 in this consortium?
Stage 2 is intended to move beyond earlier-stage team formation and proof-of-concept efforts from Stage 1 and instead build centralized capacity that can consistently support multiple projects and investigators.
What is DOCTRC?
DOCTRC refers to the Dental, Oral and Craniofacial Tissue Regeneration Consortium.
What kinds of tissues or clinical areas are targeted by this program?
The program targets dental, oral, and craniofacial (DOC) tissues, focusing on strategies for regenerating or reconstructing these tissues.
What is the overall goal of establishing these Resource Centers?
The overall goal is to accelerate the progression of DOC tissue regeneration and reconstruction strategies from laboratory or preclinical efforts toward clinical testing, using a consortium model to integrate expertise and share resources.
What role are the Resource Centers expected to play within the consortium?
The centers are framed as enablers for the entire consortium: they do not simply fund isolated research projects, but establish operational and expert resources to help translate regenerative concepts into clinically viable interventions.
What kinds of support are Resource Centers expected to provide?
They are expected to provide shared technical support and research capacity, along with the administrative infrastructure needed to coordinate consortium activities.
Is regulatory expertise a required or emphasized component of these Resource Centers?
Yes. A major emphasis is on regulatory expertise because tissue regeneration strategies often face complex development pathways, including manufacturing, quality control, and compliance expectations that arise when preparing for human trials.
Why does the FOA emphasize centralized capacity and shared resources?
Centralizing these functions is intended to reduce duplication of effort across individual research teams, standardize approaches where appropriate, and improve readiness to advance candidates into clinical trials.
What types of expertise are Resource Centers expected to integrate?
The centers are intended to integrate clinical expertise, foundational and translational science, industry know-how, and regulatory experience.
Does this FOA fund stand-alone research projects?
The FOA emphasizes that the centers are not meant to simply fund isolated research projects. Instead, they establish shared operational capacity and specialized support that serves the consortium as a whole.
What is the activity category for this opportunity?
The activity category is health.
What CFDA number is associated with this opportunity?
The associated CFDA number is 93.121.
When was this opportunity posted?
The opportunity was created and posted on April 5, 2016.
What is the application closing date?
The application closing date is July 20, 2016. The original and current closing dates match.
Who is eligible to apply?
Eligibility is broad. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with and without 501(c)(3) status (excluding institutions of higher education for those nonprofit categories as stated); for-profit organizations other than small businesses; small businesses; and other entities as described in the FOA's additional eligibility text.
Are for-profit organizations allowed to apply?
Yes. The eligibility list includes for-profit organizations other than small businesses as well as small businesses.
Are nonprofit organizations allowed to apply?
Yes. Nonprofit organizations both with and without 501(c)(3) status are included (excluding institutions of higher education for those nonprofit categories as stated).
Are colleges and universities eligible?
Yes. Both public and state-controlled institutions of higher education and private institutions of higher education are included as eligible applicants.
Are government entities eligible to apply?
Yes. The eligibility list includes several government types, including state, county, and city or township governments, special district governments, and independent school districts.
Are tribal entities eligible to apply?
Yes. Federally recognized Native American tribal governments and other tribal organizations are included as eligible applicants.
Are public housing authorities eligible to apply?
Yes. Public housing authorities/Indian housing authorities are included in the eligible applicant list.
What is the award ceiling for this opportunity?
The award ceiling listed is $2,500,000.
How many awards does NIH expect to make?
The number of expected awards is not specified in the provided data.
What problem is this program trying to address in regenerative medicine translation?
The program is designed to address the complex development pathways for tissue regeneration strategies, including challenges related to manufacturing, quality control, and regulatory compliance as teams prepare for human trials, by consolidating expertise and capacity into dedicated consortium Resource Centers.
How are these Resource Centers expected to improve clinical trial readiness?
By providing standardized shared support and strong regulatory expertise, the centers are intended to improve readiness to advance candidates into clinical trials and to push promising strategies more efficiently toward clinical testing.
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