Opportunity Information: Apply for PAR 12 243
Apply for PAR 12 243
- The National Institutes of Health in the education health income security and social services sector is offering a public funding opportunity titled "Ethical Issues in Research on HIV/AIDS and its Co morbidities (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.279 Drug Abuse and Addiction Research Programs 93.393 Cancer Cause and Prevention Research 93.394 Cancer Detection and Diagnosis Research 93.395 Cancer Treatment Research 93.396 Cancer Biology Research 93.399 Cancer Control 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Jul 24, 2012 and posted on Jul 24, 2012.
- Applicants must submit their applications by Jan 7, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments For profit organizations other than small businesses Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Public and State controlled institutions of higher education City or township governments Native American tribal governments (Federally recognized) Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The grant opportunity titled "Ethical Issues in Research on HIV/AIDS and its Co-morbidities (R21)" (Funding Opportunity Number PAR-12-243) is a National Institutes of Health (NIH) discretionary grant program designed to support focused, early-stage or exploratory research projects that tackle real-world bioethics questions arising in HIV/AIDS research. The central purpose is to strengthen the ethical foundations of studies involving people living with HIV, people with HIV-associated co-morbidities, and people at high risk of acquiring HIV. In practice, this means NIH is looking for projects that can improve how HIV-related research is designed, reviewed, and carried out, especially when studies involve complex vulnerabilities, stigmatized conditions, or challenging clinical and social contexts.
Applications are expected to align with at least one of three major goals. First, the FOA seeks the development of an empirical knowledge base that can inform human subjects protections and ethics standards in HIV/AIDS research. This points toward studies that gather data about how ethical issues actually play out on the ground, such as participant understanding during consent, barriers to voluntary participation, privacy risks, confidentiality protections in the context of stigma, or how institutional review processes address HIV-specific concerns. The emphasis on empirical work suggests NIH is open to methods like surveys, interviews, observational studies, or analyses of policy and practice, so long as the end result is actionable evidence that can strengthen participant protections and ethical oversight.
Second, the announcement encourages conceptual bioethics scholarship aimed at difficult or evolving ethical challenges in HIV/AIDS research. This part of the FOA is geared toward rigorous ethical analysis, theory development, and normative argumentation where the field may lack clear guidance. Conceptual projects might clarify ethical frameworks for research involving HIV prevention technologies, address ethical tensions in studies conducted in resource-limited settings, examine fairness and justice in participant selection, or explore how to ethically manage emerging issues such as data sharing, biobanking, genetic information, or the use of digital tools that could inadvertently expose HIV status or risk behaviors. The key idea is to produce scholarship that advances thinking and provides clearer ethical approaches for researchers, communities, and oversight bodies.
Third, the FOA explicitly supports integrating bioethics work with ongoing HIV/AIDS research. Rather than treating ethics as a separate academic exercise, NIH is inviting projects that embed ethical inquiry within active research programs, clinical trials, or public health studies. This can include collaborations where ethicists work alongside HIV researchers to identify ethical pressure points in real time and develop practical solutions, such as improved consent processes, participant engagement models, community advisory approaches, or decision tools for handling incidental findings and sensitive disclosures. This integration goal reflects an interest in ethics that is directly responsive to study realities and that can be translated into better research conduct.
This is an R21 mechanism, which generally signals an exploratory or developmental scope, and the listed award ceiling is $200,000. There is no cost sharing or matching requirement. The opportunity was posted on July 24, 2012, and the original and final closing date listed is January 7, 2015, with an archive date of February 7, 2015. While that means the specific FOA is no longer active, the summary still describes the type of work NIH was soliciting under this program announcement and can be useful for understanding NIH priorities in HIV research ethics and for tracking successor opportunities.
Eligibility is broad and includes many types of domestic and international applicants. Eligible applicants include state, county, city/township, and special district governments; public and private institutions of higher education; independent school districts; small businesses; for-profit organizations other than small businesses; nonprofit organizations with or without 501(c)(3) status; public housing authorities/Indian housing authorities; and tribal governments and tribal organizations (including federally recognized tribes and other tribal entities). The FOA also highlights additional eligible groups such as faith-based or community-based organizations, historically black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, regional organizations, and U.S. territories or possessions. Importantly, non-U.S. entities (foreign institutions) are eligible to apply, non-U.S. components of U.S. organizations may participate, and foreign components as defined by NIH policy are allowed, which underscores NIH interest in ethics questions that arise in global HIV research settings as well as U.S.-based studies.
The program is associated with multiple CFDA numbers spanning mental health, drug abuse, cancer research, infectious diseases, microbiology, allergy and infectious diseases, and child health and human development. That breadth signals that NIH viewed HIV ethics issues as cross-cutting, particularly because HIV frequently intersects with co-morbidities and related research areas such as substance use disorders, mental health conditions, infectious disease co-infections, and cancers associated with immunosuppression. The sponsoring agency is NIH, and the full announcement was hosted on the NIH grants guide site.
For support with accessing or linking to the announcement, the contact listed is the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV). The additional information link provided in the source points to the NIH guide page for PAR-12-243.
FAQs: Ethical Issues in Research on HIV/AIDS and its Co-morbidities (R21) (PAR-12-243)
What is the title and funding opportunity number for this grant?
The opportunity is titled "Ethical Issues in Research on HIV/AIDS and its Co-morbidities (R21)" and the Funding Opportunity Number is PAR-12-243.
Which agency sponsors this grant opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What type of grant mechanism is this?
This opportunity uses the NIH R21 mechanism, which generally indicates exploratory, developmental, or early-stage research projects.
What is the main purpose of this funding opportunity?
The central purpose is to support focused, early-stage or exploratory research that addresses real-world bioethics questions arising in HIV/AIDS research, with the aim of strengthening the ethical foundations of studies involving people living with HIV, people with HIV-associated co-morbidities, and people at high risk of acquiring HIV.
What kinds of ethical issues is NIH trying to address through this program?
The program targets ethical issues that affect how HIV-related research is designed, reviewed, and conducted, especially in contexts involving complex vulnerabilities, stigma, sensitive information, or challenging clinical and social environments.
What major goals are applications expected to align with?
Applications are expected to align with at least one of three goals: (1) developing an empirical knowledge base to inform human subjects protections and ethics standards in HIV/AIDS research, (2) supporting conceptual bioethics scholarship on difficult or evolving ethical challenges in HIV/AIDS research, and (3) integrating bioethics work with ongoing HIV/AIDS research.
What does it mean to develop an empirical knowledge base in this FOA?
It means generating data and evidence about how ethical issues occur in practice in HIV/AIDS research, with results that can inform or improve participant protections and ethical oversight. Examples mentioned include participant understanding during consent, barriers to voluntary participation, privacy and confidentiality risks in the context of stigma, and how review processes handle HIV-specific concerns.
What research methods appear to fit the FOA's emphasis on empirical work?
The FOA suggests NIH is open to empirical methods such as surveys, interviews, observational studies, or analyses of policy and practice, as long as the work produces actionable evidence that strengthens human subjects protections and ethical review.
What is meant by conceptual bioethics scholarship under this announcement?
Conceptual bioethics scholarship refers to rigorous ethical analysis, theory development, and normative argumentation that helps address ethical challenges where the field may lack clear guidance, with the goal of advancing ethical thinking and providing clearer approaches for researchers, communities, and oversight bodies.
What kinds of topics are highlighted as examples of conceptual bioethics work?
Examples include ethical frameworks for research involving HIV prevention technologies, ethical tensions in studies conducted in resource-limited settings, fairness and justice in participant selection, and ethical management of emerging issues such as data sharing, biobanking, genetic information, and the use of digital tools that could expose HIV status or risk behaviors.
What does it mean to integrate bioethics work with ongoing HIV/AIDS research?
It means embedding ethical inquiry within active HIV/AIDS research programs, clinical trials, or public health studies, often through collaboration between ethicists and HIV researchers to identify ethical pressure points in real time and develop practical solutions that can improve study conduct.
What kinds of practical solutions are mentioned for integrated ethics projects?
Examples include improved consent processes, participant engagement models, community advisory approaches, and decision tools for handling incidental findings and sensitive disclosures.
What is the maximum award amount listed for this R21?
The listed award ceiling is $200,000.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
When was this opportunity posted?
The opportunity was posted on July 24, 2012.
What were the closing dates and archive date for this FOA?
The original and final closing date listed is January 7, 2015, and the archive date is February 7, 2015.
Is this funding opportunity still active?
No. Based on the closing and archive dates provided, this specific FOA is no longer active.
If the FOA is inactive, why might the summary still be useful?
The summary can still help readers understand the kinds of HIV research ethics work NIH was soliciting under this program announcement, NIH priorities in HIV research ethics, and how to track or anticipate successor opportunities.
Who is eligible to apply?
Eligibility is broad and includes domestic and international applicants. Eligible applicants include various U.S. government entities (state, county, city/township, special district), public and private institutions of higher education, independent school districts, small businesses, for-profit organizations other than small businesses, and nonprofit organizations with or without 501(c)(3) status, as well as public housing authorities/Indian housing authorities and tribal governments/tribal organizations.
Are faith-based and community-based organizations included in eligible applicant types?
Yes. The FOA highlights faith-based or community-based organizations among eligible groups.
Are minority-serving institutions specifically mentioned as eligible?
Yes. The FOA specifically highlights HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), and Alaska Native and Native Hawaiian serving institutions.
Are U.S. territories or possessions eligible?
Yes. The FOA highlights U.S. territories or possessions as eligible.
Can foreign institutions apply?
Yes. Non-U.S. entities (foreign institutions) are eligible to apply.
Can non-U.S. components of U.S. organizations participate?
Yes. The FOA states that non-U.S. components of U.S. organizations may participate.
Are foreign components allowed under NIH policy?
Yes. The FOA indicates that foreign components, as defined by NIH policy, are allowed.
What does the FOA's international eligibility suggest about the kinds of ethics issues NIH expects?
It underscores interest in ethical questions that arise in global HIV research settings as well as U.S.-based studies, including issues relevant to resource-limited settings.
What research areas does this opportunity connect to besides HIV?
The FOA is associated with multiple CFDA numbers spanning areas such as mental health, drug abuse, cancer research, infectious diseases, microbiology, allergy and infectious diseases, and child health and human development, signaling that HIV ethics issues are viewed as cross-cutting and often intertwined with co-morbidities.
Why does the FOA emphasize co-morbidities?
The description indicates HIV frequently intersects with co-morbidities and related research areas like substance use disorders, mental health conditions, infectious disease co-infections, and cancers associated with immunosuppression, creating additional ethical complexities in research.
Where was the full announcement hosted?
The full announcement was hosted on the NIH grants guide site, and the source references an NIH guide page for PAR-12-243.
Who is listed as a contact for help accessing or linking to the announcement?
The contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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